Can Command R 35B run on AMD Instinct MI350X 288GB?

YES — Runs Great

A72Great

Estimated from fit model

Command R 35B needs ~53.5 GB VRAM. AMD Instinct MI350X 288GB has 288.0 GB. With Q4_K_M quantization, expect ~298 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 53.5 GB, 297.5 tok/s, Runs well

53.5 GB required288.0 GB available

19% VRAM used

Fit status

Runs well

Decode

297.5 tok/s

TTFT

651 ms

Safe context

131K

Memory

53.5 GB / 288.0 GB

Memory breakdown

Weights21.3 GB

KV Cache2.4 GB

Runtime0.9 GB

Headroom28.8 GB

See how fast it feels

See how fast it feelsCommand R 35B on AMD Instinct MI350X 288GB
1st promptCold start — includes initialization
>What is local AI inference?
Local AI inference means running an AI language model directly on your own hardware — your laptop, desktop, or server — instead of sending requests to a remote cloud API.

When you run inference locally the model weights are loaded into your GPU or unified memory. Each token you generate requires reading those weights from memory, so memory bandwidth is the main bottleneck for decode speed.

Key benefits of running locally:
  - Full privacy: your prompts never leave your machine
  - No per-token cost or rate limits
  - Works offline once the model is downloaded
  - Latency depends only on your hardware
2nd promptWarm — model ready, no init overhead
>How much VRAM do I need?
It depends on the model size and quantization level. A rough rule of thumb:

  Model size     Q4 (4-bit)    Q8 (8-bit)    FP16
  7B params      ~4.3 GB       ~7.5 GB       ~14 GB
  13B params     ~7.9 GB       ~13.9 GB      ~26 GB
  70B params     ~42.7 GB      ~74.9 GB      ~140 GB

Most people use 4-bit quantization (Q4_K_M) which gives 90-95% of full quality at a fraction of the memory. A 24 GB GPU can comfortably run most 7B-13B models.
Estimated: 297.5 tok/s decode · 651ms TTFT (warm) · 744 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	A	Runs well	297.5 tok/s	355 ms	131K
Coding	A	Runs well	297.5 tok/s	651 ms	131K
Agentic Coding	A	Runs well	297.5 tok/s	947 ms	131K
Reasoning	A	Runs well	297.5 tok/s	769 ms	131K
RAG	A	Runs well	297.5 tok/s	1183 ms	131K

Quantization options

How Command R 35B (35B params) fits at each quantization level on AMD Instinct MI350X 288GB (288.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	13.7 GB	Low	B63
Q3_K_S	3	17.2 GB	Low	B63
NVFP4	4	19.6 GB	Medium	B63
Q4_K_M	4	21.3 GB	Medium	B63
Q5_K_M	5	25.2 GB	High	B63
Q6_K	6	28.7 GB	High	B64
Q8_0	8	37.5 GB	Very High	B64
F16Best for your GPU	16	71.8 GB	Maximum	B67

Get started

Copy-paste commands to run Command R 35B on your machine.

Run

ollama run command-r

Your hardware

More models your AMD Instinct MI350X 288GB can run

Model	Params	Grade	Decode
Qwen 3.5 397B A17B	397B	S	78.9 tok/s
Devstral 2 123B Instruct	123B	S	84.6 tok/s
Qwen 3.5 122B A10B	122B	S	234.8 tok/s
DeepSeek V4 Flash	284B	S	125.8 tok/s
Mistral Small 4 119B	119B	S	254.6 tok/s

Frequently asked questions

Can AMD Instinct MI350X 288GB run Command R 35B?

Yes, AMD Instinct MI350X 288GB can run Command R 35B with a A grade (Runs well). Expected decode speed: 297.5 tok/s.

How much VRAM does Command R 35B need?

Command R 35B (35B parameters) requires approximately 53.5 GB of memory with Q4_K_M quantization.

What is the best quantization for Command R 35B?

The recommended quantization for Command R 35B is Q4_K_M, which balances quality and memory efficiency.

What speed will Command R 35B run at on AMD Instinct MI350X 288GB?

On AMD Instinct MI350X 288GB, Command R 35B achieves approximately 297.5 tokens per second decode speed with a time-to-first-token of 651ms using Q4_K_M quantization.

Can AMD Instinct MI350X 288GB run Command R 35B for coding?

For coding workloads, Command R 35B on AMD Instinct MI350X 288GB receives a A grade with 297.5 tok/s and 131K context.

What context window can Command R 35B use on AMD Instinct MI350X 288GB?

On AMD Instinct MI350X 288GB, Command R 35B can safely use up to 131K tokens of context. The model's official context limit is 131K, but available memory constrains the safe maximum.

See all results for AMD Instinct MI350X 288GB See all hardware for Command R 35B

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Preview:

Workload

Grade

Fit

Decode

TTFT

Context

Chat

Runs well

297.5 tok/s

355 ms

131K

Coding

Runs well

297.5 tok/s

651 ms

131K

Agentic Coding

Runs well

297.5 tok/s

947 ms

131K

Reasoning

Runs well

297.5 tok/s

769 ms

131K

RAG

Runs well

297.5 tok/s

1183 ms

131K

Quantization options

How Command R 35B (35B params) fits at each quantization level on AMD Instinct MI350X 288GB (288.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	13.7 GB	Low	B63
Q3_K_S	3	17.2 GB	Low	B63
NVFP4	4	19.6 GB	Medium	B63
Q4_K_M	4	21.3 GB	Medium	B63
Q5_K_M	5	25.2 GB	High	B63
Q6_K	6	28.7 GB	High	B64
Q8_0	8	37.5 GB	Very High	B64
F16Best for your GPU	16	71.8 GB	Maximum	B67

Model

Params

Grade

Decode

Capabilities

Qwen 3.5 397B A17B

397B

78.9 tok/s

Devstral 2 123B Instruct

123B

84.6 tok/s

Qwen 3.5 122B A10B

122B

234.8 tok/s

DeepSeek V4 Flash

284B

125.8 tok/s

Mistral Small 4 119B

119B

254.6 tok/s

Frequently asked questions

Can AMD Instinct MI350X 288GB run Command R 35B?

Yes, AMD Instinct MI350X 288GB can run Command R 35B with a A grade (Runs well). Expected decode speed: 297.5 tok/s.

How much VRAM does Command R 35B need?

Command R 35B (35B parameters) requires approximately 53.5 GB of memory with Q4_K_M quantization.

What is the best quantization for Command R 35B?

The recommended quantization for Command R 35B is Q4_K_M, which balances quality and memory efficiency.

What speed will Command R 35B run at on AMD Instinct MI350X 288GB?

On AMD Instinct MI350X 288GB, Command R 35B achieves approximately 297.5 tokens per second decode speed with a time-to-first-token of 651ms using Q4_K_M quantization.

Can AMD Instinct MI350X 288GB run Command R 35B for coding?

For coding workloads, Command R 35B on AMD Instinct MI350X 288GB receives a A grade with 297.5 tok/s and 131K context.

What context window can Command R 35B use on AMD Instinct MI350X 288GB?

On AMD Instinct MI350X 288GB, Command R 35B can safely use up to 131K tokens of context. The model's official context limit is 131K, but available memory constrains the safe maximum.