Can Qwen 3.5 397B A17B run on AMD Instinct MI350X 288GB?

YES — With Offload

S97Excellent

Estimated from fit model

Qwen 3.5 397B A17B needs ~274.7 GB VRAM. AMD Instinct MI350X 288GB has 288.0 GB. With Q4_K_M quantization, expect ~79 tok/s.

Runtime: llama.cppCapacity: OffloadBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 274.7 GB, 78.9 tok/s, Runs with offload

274.7 GB required288.0 GB available

95% VRAM used

Fit status

Runs with offload

Decode

78.9 tok/s

TTFT

2453 ms

Safe context

90K

Memory

274.7 GB / 288.0 GB

Memory breakdown

Weights242.2 GB

KV Cache2.9 GB

Runtime0.9 GB

Headroom28.8 GB

See how fast it feels

See how fast it feelsQwen 3.5 397B A17B on AMD Instinct MI350X 288GB
1st promptCold start — includes initialization
>Write a Python function to sort a list
Here's a Python function that sorts a list using quicksort:

def quicksort(arr):
    if len(arr) <= 1:
        return arr
    pivot = arr[len(arr) // 2]
    left   = [x for x in arr if x < pivot]
    middle = [x for x in arr if x == pivot]
    right  = [x for x in arr if x > pivot]
    return quicksort(left) + middle + quicksort(right)

# Example usage
numbers = [3, 6, 8, 10, 1, 2, 1]
print(quicksort(numbers))  # [1, 1, 2, 3, 6, 8, 10]

The algorithm picks a pivot, partitions the list into smaller, equal, and larger elements, then recursively sorts each partition and concatenates the results.
2nd promptWarm — model ready, no init overhead
>Now add type hints and a docstring
def quicksort(arr: list[int]) -> list[int]:
    """Sort a list using the quicksort algorithm.

    Args:
        arr: List of integers to sort.

    Returns:
        A new sorted list.
    """
    if len(arr) <= 1:
        return arr
    pivot = arr[len(arr) // 2]
    left   = [x for x in arr if x < pivot]
    middle = [x for x in arr if x == pivot]
    right  = [x for x in arr if x > pivot]
    return quicksort(left) + middle + quicksort(right)

Added type hints for the input and return type, plus a Google-style docstring.
Estimated: 78.9 tok/s decode · 2.5s TTFT (warm) · 197 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

Very little memory headroom

You can run the model, but there is not much room left for longer context, bigger batches, extra apps, or future model updates.

Best improvement path

Buy headroom, not only minimum fit

A slightly larger memory tier gives you safer context growth and makes the recommendation more future-proof.

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	S	Tight fit	78.9 tok/s	1338 ms	90K
Coding	S	Runs with offload	78.9 tok/s	2453 ms	90K
Agentic Coding	S	Runs with offload	78.9 tok/s	3569 ms	90K
Reasoning	S	Runs with offload	78.9 tok/s	2900 ms	90K
RAG	S	Runs with offload	78.9 tok/s	4461 ms	90K

Inference speed

Qwen 3.5 397B A17B inference speed — tokens per second by GPU & Mac

Estimated decode speed (tokens/sec) for Qwen 3.5 397B A17B at Q4_K_M across popular GPUs and Apple Silicon, including multi-GPU rigs, using the fastest local runtime per device. Fastest is Mac Studio M3 Ultra 256GB at ~7 tok/s. Speed is memory-bandwidth bound, so cards that fit the whole model in VRAM run far faster than ones that offload to system RAM.

GPU / Mac	Memory	Quant	Speed (tok/s)	Fits?
Mac Studio M3 Ultra 256GB	256 GB	Q4_K_M	6.9	Too big
Mac Studio M2 Ultra 128GB	128 GB	Q4_K_M	4.4	Too big
Mac Studio M1 Ultra 128GB	128 GB	Q4_K_M	4.1	Too big
MacBook Pro M4 Max 128GB	128 GB	Q4_K_M	3.2	Too big
MacBook Pro M4 Max 64GB	64 GB	Q4_K_M	3.2	Too big
RTX 5090 32GB	32 GB	Q4_K_M	2.4	Too big
2× RX 7900 XTX 24GB	48 GB	Q4_K_M	2.4	Too big
MacBook Pro M3 Max 64GB	64 GB	Q4_K_M	2.3	Too big
MacBook Pro M1 Max 64GB	64 GB	Q4_K_M	2.1	Too big
RTX 4090 24GB	24 GB	Q4_K_M	2.0	Too big
RTX 4080 Super 16GB	16 GB	Q4_K_M	2.0	Too big
RTX 3090 24GB	24 GB	Q4_K_M	2.0	Too big
RTX 4070 12GB	12 GB	Q4_K_M	2.0	Too big
RTX 3060 12GB	12 GB	Q4_K_M	2.0	Too big
RTX 4060 8GB	8 GB	Q4_K_M	2.0	Too big
RX 7900 XTX 24GB	24 GB	Q4_K_M	2.0	Too big
MacBook Pro M4 Pro 48GB	48 GB	Q4_K_M	2.0	Too big
2× RTX 4090 24GB	48 GB	Q4_K_M	2.0	Too big
2× RTX 3090 24GB	48 GB	Q4_K_M	2.0	Too big
4× RTX 3060 12GB	48 GB	Q4_K_M	2.0	Too big

Estimates for single-stream decoding at Q4_K_M; real tokens/sec varies with prompt length, context, batch size, and runtime build. Prompt processing (prefill) is faster than the decode figures shown here.

Quantization options

How Qwen 3.5 397B A17B (397B params) fits at each quantization level on AMD Instinct MI350X 288GB (288.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	154.8 GB	Low	S91
Q3_K_S	3	194.5 GB	Low	S91
NVFP4Best for your GPU	4	222.3 GB	Medium	S91
Q4_K_M	4	242.2 GB	Medium	F0
Q5_K_M	5	285.8 GB	High	F0
Q6_K	6	325.5 GB	High	F0
Q8_0	8	424.8 GB	Very High	F0
F16	16	813.8 GB	Maximum	F0

Get started

Copy-paste commands to run Qwen 3.5 397B A17B on your machine.

Run

docker run --rm -it ghcr.io/ggerganov/llama.cpp:full \
  --hf-repo "Qwen/Qwen3.5-397B-A17B-Instruct" \
  --hf-file "Qwen3.5-397B-A17B-Instruct-Q4_K_M.gguf" \
  -c 4096 -ngl 99

Frequently asked questions

Can AMD Instinct MI350X 288GB run Qwen 3.5 397B A17B?

Yes, AMD Instinct MI350X 288GB can run Qwen 3.5 397B A17B with a S grade (Runs with offload). Expected decode speed: 78.9 tok/s.

How much VRAM does Qwen 3.5 397B A17B need?

Qwen 3.5 397B A17B (397B parameters) requires approximately 274.7 GB of memory with Q4_K_M quantization.

What is the best quantization for Qwen 3.5 397B A17B?

The recommended quantization for Qwen 3.5 397B A17B is Q4_K_M, which balances quality and memory efficiency.

What speed will Qwen 3.5 397B A17B run at on AMD Instinct MI350X 288GB?

On AMD Instinct MI350X 288GB, Qwen 3.5 397B A17B achieves approximately 78.9 tokens per second decode speed with a time-to-first-token of 2453ms using Q4_K_M quantization.

Can AMD Instinct MI350X 288GB run Qwen 3.5 397B A17B for coding?

For coding workloads, Qwen 3.5 397B A17B on AMD Instinct MI350X 288GB receives a S grade with 78.9 tok/s and 90K context.

What context window can Qwen 3.5 397B A17B use on AMD Instinct MI350X 288GB?

On AMD Instinct MI350X 288GB, Qwen 3.5 397B A17B can safely use up to 90K tokens of context. The model's official context limit is 131K, but available memory constrains the safe maximum.

What should I upgrade first if Qwen 3.5 397B A17B feels slow on AMD Instinct MI350X 288GB?

Buy headroom, not only minimum fit. A slightly larger memory tier gives you safer context growth and makes the recommendation more future-proof.

See all results for AMD Instinct MI350X 288GB See all hardware for Qwen 3.5 397B A17B

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<iframe src="https://willitrunai.com/embed/qwen-3.5-397b-a17b-on-instinct-mi350x-288gb" width="400" height="180" frameborder="0" style="border:none;border-radius:12px;overflow:hidden;" title="Will It Run AI — fit result"></iframe>

Preview:

Workload

Grade

Fit

Decode

TTFT

Context

Chat

Tight fit

78.9 tok/s

1338 ms

90K

Coding

Runs with offload

78.9 tok/s

2453 ms

90K

Agentic Coding

Runs with offload

78.9 tok/s

3569 ms

90K

Reasoning

Runs with offload

78.9 tok/s

2900 ms

90K

RAG

Runs with offload

78.9 tok/s

4461 ms

90K

Qwen 3.5 397B A17B inference speed — tokens per second by GPU & Mac

GPU / Mac

Memory

Quant

Speed (tok/s)

Fits?

Mac Studio M3 Ultra 256GB

256 GB

Q4_K_M

6.9

Too big

Mac Studio M2 Ultra 128GB

128 GB

Q4_K_M

4.4

Too big

Mac Studio M1 Ultra 128GB

128 GB

Q4_K_M

4.1

Too big

MacBook Pro M4 Max 128GB

128 GB

Q4_K_M

3.2

Too big

MacBook Pro M4 Max 64GB

64 GB

Q4_K_M

3.2

Too big

RTX 5090 32GB

32 GB

Q4_K_M

2.4

Too big

2× RX 7900 XTX 24GB

48 GB

Q4_K_M

2.4

Too big

MacBook Pro M3 Max 64GB

64 GB

Q4_K_M

2.3

Too big

MacBook Pro M1 Max 64GB

64 GB

Q4_K_M

2.1

Too big

RTX 4090 24GB

24 GB

Q4_K_M

2.0

Too big

RTX 4080 Super 16GB

16 GB

Q4_K_M

2.0

Too big

RTX 3090 24GB

24 GB

Q4_K_M

2.0

Too big

RTX 4070 12GB

12 GB

Q4_K_M

2.0

Too big

RTX 3060 12GB

12 GB

Q4_K_M

2.0

Too big

RTX 4060 8GB

8 GB

Q4_K_M

2.0

Too big

RX 7900 XTX 24GB

24 GB

Q4_K_M

2.0

Too big

MacBook Pro M4 Pro 48GB

48 GB

Q4_K_M

2.0

Too big

2× RTX 4090 24GB

48 GB

Q4_K_M

2.0

Too big

2× RTX 3090 24GB

48 GB

Q4_K_M

2.0

Too big

4× RTX 3060 12GB

48 GB

Q4_K_M

2.0

Too big

Quantization options

How Qwen 3.5 397B A17B (397B params) fits at each quantization level on AMD Instinct MI350X 288GB (288.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	154.8 GB	Low	S91
Q3_K_S	3	194.5 GB	Low	S91
NVFP4Best for your GPU	4	222.3 GB	Medium	S91
Q4_K_M	4	242.2 GB	Medium	F0
Q5_K_M	5	285.8 GB	High	F0
Q6_K	6	325.5 GB	High	F0
Q8_0	8	424.8 GB	Very High	F0
F16	16	813.8 GB	Maximum	F0