Qwen 3.5 122B A10B needs ~106.6 GB VRAM. AMD Instinct MI350X 288GB has 288.0 GB. With Q4_K_M quantization, expect ~235 tok/s.
Operating mode
Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.
Current mode
Balanced
Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.
Select quantization to explore
Fit status
Runs well
Decode
234.8 tok/s
TTFT
825 ms
Safe context
131K
Memory
106.6 GB / 288.0 GB
This setup is broadly balanced for this model.
No major red flags
This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.
| Workload | Grade | Fit | Decode | TTFT | Context |
|---|---|---|---|---|---|
| Chat | S | Runs well | 234.8 tok/s | 450 ms | 131K |
| Coding | S | Runs well | 234.8 tok/s | 825 ms | 131K |
| Agentic Coding | S | Runs well | 234.8 tok/s | 1199 ms | 131K |
| Reasoning | S | Runs well | 234.8 tok/s | 975 ms | 131K |
| RAG | S | Runs well | 234.8 tok/s | 1499 ms | 131K |
How Qwen 3.5 122B A10B (122B params) fits at each quantization level on AMD Instinct MI350X 288GB (288.0 GB usable).
| Quant | Bits | VRAM | Quality | Fit |
|---|---|---|---|---|
Q2_K | 2 | 47.6 GB | Low | A81 |
Q3_K_S | 3 | 59.8 GB | Low | A82 |
NVFP4 | 4 |
Copy-paste commands to run Qwen 3.5 122B A10B on your machine.
Run
lms load Qwen3.5-122B-A10B-Instruct && lms server startYour hardware
| Model | Params | Grade | Decode | Capabilities |
|---|---|---|---|---|
| 397B | S | 78.9 tok/s | ||
| 123B | S |
Yes, AMD Instinct MI350X 288GB can run Qwen 3.5 122B A10B with a S grade (Runs well). Expected decode speed: 234.8 tok/s.
Qwen 3.5 122B A10B (122B parameters) requires approximately 106.6 GB of memory with Q4_K_M quantization.
The recommended quantization for Qwen 3.5 122B A10B is Q4_K_M, which balances quality and memory efficiency.
On AMD Instinct MI350X 288GB, Qwen 3.5 122B A10B achieves approximately 234.8 tokens per second decode speed with a time-to-first-token of 825ms using Q4_K_M quantization.
For coding workloads, Qwen 3.5 122B A10B on AMD Instinct MI350X 288GB receives a S grade with 234.8 tok/s and 131K context.
On AMD Instinct MI350X 288GB, Qwen 3.5 122B A10B can safely use up to 131K tokens of context. The model's official context limit is 131K, but available memory constrains the safe maximum.
Paste this snippet into any page to show a live fit card.
<iframe src="https://willitrunai.com/embed/qwen-3.5-122b-a10b-on-instinct-mi350x-288gb" width="400" height="180" frameborder="0" style="border:none;border-radius:12px;overflow:hidden;" title="Will It Run AI — fit result"></iframe>
Preview:
68.3 GB |
| Medium |
| A83 |
Q4_K_M | 4 | 74.4 GB | Medium | A83 |
Q5_K_M | 5 | 87.8 GB | High | A84 |
Q6_K | 6 | 100.0 GB | High | S85 |
Q8_0 | 8 | 130.5 GB | Very High | S88 |
F16Best for your GPU | 16 | 250.1 GB | Maximum | S90 |
| 84.6 tok/s |