Can Qwen 3.5 122B A10B run on AMD Instinct MI210 64GB?

YES — With Q3_K_S

A83Great

Estimated from fit model

Qwen 3.5 122B A10B needs ~69.5 GB VRAM. AMD Instinct MI210 64GB has 64.0 GB. With Q3_K_S quantization, expect ~33 tok/s.

Runtime: llama.cppCapacity: OffloadBandwidth: HighStack: StandardBottleneck: Host offload

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Qwen 3.5 122B A10B at Q4_K_M needs 84.2 GB — too much for AMD Instinct MI210 64GB (64.0 GB). Runs at Q3_K_S (69.5 GB) with low quality. 2 quantization levels fit.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 84.2 GB, exceeds 64.0 GB available

84.2 GB required64.0 GB available

132% VRAM needed

20.2 GB over capacity — needs offload or smaller quantization

Fit status

Too heavy

Decode

18.9 tok/s

TTFT

10259 ms

Safe context

Memory

84.2 GB / 64.0 GB

Offload

20%

Memory breakdown

Weights74.4 GB

KV Cache2.4 GB

Runtime0.9 GB

Headroom6.4 GB

See how fast it feels

With memory offload — actual speed may be lower

See how fast it feelsQwen 3.5 122B A10B on AMD Instinct MI210 64GB
1st promptCold start — includes initialization
>Write a Python function to sort a list
Here's a Python function that sorts a list using quicksort:

def quicksort(arr):
    if len(arr) <= 1:
        return arr
    pivot = arr[len(arr) // 2]
    left   = [x for x in arr if x < pivot]
    middle = [x for x in arr if x == pivot]
    right  = [x for x in arr if x > pivot]
    return quicksort(left) + middle + quicksort(right)

# Example usage
numbers = [3, 6, 8, 10, 1, 2, 1]
print(quicksort(numbers))  # [1, 1, 2, 3, 6, 8, 10]

The algorithm picks a pivot, partitions the list into smaller, equal, and larger elements, then recursively sorts each partition and concatenates the results.
2nd promptWarm — model ready, no init overhead
>Now add type hints and a docstring
def quicksort(arr: list[int]) -> list[int]:
    """Sort a list using the quicksort algorithm.

    Args:
        arr: List of integers to sort.

    Returns:
        A new sorted list.
    """
    if len(arr) <= 1:
        return arr
    pivot = arr[len(arr) // 2]
    left   = [x for x in arr if x < pivot]
    middle = [x for x in arr if x == pivot]
    right  = [x for x in arr if x > pivot]
    return quicksort(left) + middle + quicksort(right)

Added type hints for the input and return type, plus a Google-style docstring.
Estimated: 18.9 tok/s decode · 10.3s TTFT (warm) · 47 tok/s prefill

What limits this setup

It fits through host-memory offload, and offload is the main reason performance drops.

CPU or host-memory offload is active

About 10% of the working set spills out of accelerator memory, which usually hurts latency and sustained decode throughput.

Very little memory headroom

You can run the model, but there is not much room left for longer context, bigger batches, extra apps, or future model updates.

Best improvement path

Remove offload with more accelerator memory

Prioritize a GPU or unified-memory tier that fits the whole model natively. Removing offload usually helps more than small compute gains.

Buy headroom, not only minimum fit

A slightly larger memory tier gives you safer context growth and makes the recommendation more future-proof.

Increase host RAM if you keep offloading

This setup may need roughly 4.7 GB of extra host RAM just for the offloaded portion, before OS and other tools.

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	F	Too heavy	19.5 tok/s	5427 ms	4K
Coding	F	Too heavy	18.9 tok/s	10259 ms	4K
Agentic Coding	F	Too heavy	17.8 tok/s	15849 ms	4K
Reasoning	F	Too heavy	18.9 tok/s	12125 ms	4K
RAG	F	Too heavy	17.8 tok/s	19811 ms	4K

Quantization options

How Qwen 3.5 122B A10B (122B params) fits at each quantization level on AMD Instinct MI210 64GB (64.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_KBest for your GPU	2	47.6 GB	Low	S90
Q3_K_S	3	59.8 GB	Low	F0
NVFP4	4	68.3 GB	Medium	F0
Q4_K_M	4	74.4 GB	Medium	F0
Q5_K_M	5	87.8 GB	High	F0
Q6_K	6	100.0 GB	High	F0
Q8_0	8	130.5 GB	Very High	F0
F16	16	250.1 GB	Maximum	F0

Get started

Copy-paste commands to run Qwen 3.5 122B A10B on your machine.

Run

lms load Qwen3.5-122B-A10B-Instruct && lms server start

升级选项

能流畅运行 Qwen 3.5 122B A10B 的硬件

AMD Instinct MI350X 288GB经济之选

288 GB VRAM (+224)8000 GB/s (+6362)

Makes the model fit on the accelerator instead of staying completely out of reach.234.8 tok/s 解码

Makes the model fit on the accelerator instead of staying completely out of reach.

Removes host-memory offload, which is usually the single biggest latency and throughput win.

~$8,000 MSRP

AMD Instinct MI300A 128GB最佳性价比

128 GB VRAM (+64)5300 GB/s (+3662)

Makes the model fit on the accelerator instead of staying completely out of reach.149.2 tok/s 解码

Makes the model fit on the accelerator instead of staying completely out of reach.

Removes host-memory offload, which is usually the single biggest latency and throughput win.

~$12,000 MSRP

AMD Instinct MI250X 128GBAMD 升级

128 GB VRAM (+64)3200 GB/s (+1562)

Makes the model fit on the accelerator instead of staying completely out of reach.100.3 tok/s 解码

Makes the model fit on the accelerator instead of staying completely out of reach.

Removes host-memory offload, which is usually the single biggest latency and throughput win.

~$15,000 MSRP

Frequently asked questions

Can AMD Instinct MI210 64GB run Qwen 3.5 122B A10B?

Yes, AMD Instinct MI210 64GB can run Qwen 3.5 122B A10B at Q3_K_S quantization (Very compromised (needs ~4.7 GB host RAM)). The recommended Q4_K_M requires 84.2 GB which exceeds available memory, but at Q3_K_S it needs only 69.5 GB. Expected decode speed: 32.7 tok/s.

How much VRAM does Qwen 3.5 122B A10B need?

Qwen 3.5 122B A10B (122B parameters) requires approximately 84.2 GB at Q4_K_M quantization. On AMD Instinct MI210 64GB, it fits at Q3_K_S using 69.5 GB.

What is the best quantization for Qwen 3.5 122B A10B?

The recommended quantization is Q4_K_M, but on AMD Instinct MI210 64GB the best fitting quantization is Q3_K_S, which uses 69.5 GB.

What speed will Qwen 3.5 122B A10B run at on AMD Instinct MI210 64GB?

On AMD Instinct MI210 64GB, Qwen 3.5 122B A10B achieves approximately 32.7 tokens per second decode speed with a time-to-first-token of 5927ms using Q3_K_S quantization.

Can AMD Instinct MI210 64GB run Qwen 3.5 122B A10B for coding?

For coding workloads, Qwen 3.5 122B A10B on AMD Instinct MI210 64GB receives a F grade with 18.9 tok/s and 4K context.

What context window can Qwen 3.5 122B A10B use on AMD Instinct MI210 64GB?

On AMD Instinct MI210 64GB, Qwen 3.5 122B A10B can safely use up to 4K tokens of context at Q3_K_S quantization. The model's official context limit is 131K, but available memory constrains the safe maximum.

What should I upgrade first if Qwen 3.5 122B A10B feels slow on AMD Instinct MI210 64GB?

Remove offload with more accelerator memory. Prioritize a GPU or unified-memory tier that fits the whole model natively. Removing offload usually helps more than small compute gains.

See all results for AMD Instinct MI210 64GB See all hardware for Qwen 3.5 122B A10B

Embed this result▼

Paste this snippet into any page to show a live fit card.

<iframe src="https://willitrunai.com/embed/qwen-3.5-122b-a10b-on-instinct-mi210-64gb" width="400" height="180" frameborder="0" style="border:none;border-radius:12px;overflow:hidden;" title="Will It Run AI — fit result"></iframe>

Preview: