Can Mistral Small 24B run on AMD Instinct MI250X 128GB?

YES — Runs Great

A79Great

Estimated from fit model

Mistral Small 24B needs ~30.8 GB VRAM. AMD Instinct MI250X 128GB has 128.0 GB. With Q4_K_M quantization, expect ~183 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 30.8 GB, 183.3 tok/s, Runs well

30.8 GB required128.0 GB available

24% VRAM used

Fit status

Runs well

Decode

183.3 tok/s

TTFT

1056 ms

Safe context

33K

Memory

30.8 GB / 128.0 GB

Memory breakdown

Weights14.6 GB

KV Cache2.4 GB

Runtime0.9 GB

Headroom12.8 GB

See how fast it feels

See how fast it feelsMistral Small 24B on AMD Instinct MI250X 128GB
1st promptCold start — includes initialization
>Write a Python function to sort a list
Here's a Python function that sorts a list using quicksort:

def quicksort(arr):
    if len(arr) <= 1:
        return arr
    pivot = arr[len(arr) // 2]
    left   = [x for x in arr if x < pivot]
    middle = [x for x in arr if x == pivot]
    right  = [x for x in arr if x > pivot]
    return quicksort(left) + middle + quicksort(right)

# Example usage
numbers = [3, 6, 8, 10, 1, 2, 1]
print(quicksort(numbers))  # [1, 1, 2, 3, 6, 8, 10]

The algorithm picks a pivot, partitions the list into smaller, equal, and larger elements, then recursively sorts each partition and concatenates the results.
2nd promptWarm — model ready, no init overhead
>Now add type hints and a docstring
def quicksort(arr: list[int]) -> list[int]:
    """Sort a list using the quicksort algorithm.

    Args:
        arr: List of integers to sort.

    Returns:
        A new sorted list.
    """
    if len(arr) <= 1:
        return arr
    pivot = arr[len(arr) // 2]
    left   = [x for x in arr if x < pivot]
    middle = [x for x in arr if x == pivot]
    right  = [x for x in arr if x > pivot]
    return quicksort(left) + middle + quicksort(right)

Added type hints for the input and return type, plus a Google-style docstring.
Estimated: 183.3 tok/s decode · 1.1s TTFT (warm) · 458 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	A	Runs well	183.3 tok/s	576 ms	33K
Coding	A	Runs well	183.3 tok/s	1056 ms	33K
Agentic Coding	A	Runs well	183.3 tok/s	1536 ms	33K
Reasoning	A	Runs well	183.3 tok/s	1248 ms	33K
RAG	A	Runs well	183.3 tok/s	1921 ms	33K

Quantization options

How Mistral Small 24B (24B params) fits at each quantization level on AMD Instinct MI250X 128GB (128.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	9.4 GB	Low	A70
Q3_K_S	3	11.8 GB	Low	A70
NVFP4	4	13.4 GB	Medium	A71
Q4_K_M	4	14.6 GB	Medium	A71
Q5_K_M	5	17.3 GB	High	A71
Q6_K	6	19.7 GB	High	A71
Q8_0	8	25.7 GB	Very High	A72
F16Best for your GPU	16	49.2 GB	Maximum	A76

Get started

Copy-paste commands to run Mistral Small 24B on your machine.

Run

ollama run mistral-small

Your hardware

More models your AMD Instinct MI250X 128GB can run

Model	Params	Grade	Decode
Devstral 2 123B Instruct	123B	S	36.2 tok/s
Qwen3-Coder 30B A3B Instruct	30.5B	S	377.4 tok/s
Qwen 3.5 27B	27B	S	163.7 tok/s
Qwen 3.6 27B	27B	S	102 tok/s
Qwen 3.5 122B A10B	122B	S	100.3 tok/s

Frequently asked questions

Can AMD Instinct MI250X 128GB run Mistral Small 24B?

Yes, AMD Instinct MI250X 128GB can run Mistral Small 24B with a A grade (Runs well). Expected decode speed: 183.3 tok/s.

How much VRAM does Mistral Small 24B need?

Mistral Small 24B (24B parameters) requires approximately 30.8 GB of memory with Q4_K_M quantization.

What is the best quantization for Mistral Small 24B?

The recommended quantization for Mistral Small 24B is Q4_K_M, which balances quality and memory efficiency.

What speed will Mistral Small 24B run at on AMD Instinct MI250X 128GB?

On AMD Instinct MI250X 128GB, Mistral Small 24B achieves approximately 183.3 tokens per second decode speed with a time-to-first-token of 1056ms using Q4_K_M quantization.

Can AMD Instinct MI250X 128GB run Mistral Small 24B for coding?

For coding workloads, Mistral Small 24B on AMD Instinct MI250X 128GB receives a A grade with 183.3 tok/s and 33K context.

What context window can Mistral Small 24B use on AMD Instinct MI250X 128GB?

On AMD Instinct MI250X 128GB, Mistral Small 24B can safely use up to 33K tokens of context. The model's official context limit is 33K, but available memory constrains the safe maximum.

See all results for AMD Instinct MI250X 128GB See all hardware for Mistral Small 24B

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