Can Devstral 2 123B Instruct run on AMD Instinct MI250X 128GB?

YES — Runs Great

S97Excellent

Estimated from fit model

Devstral 2 123B Instruct needs ~94.1 GB VRAM. AMD Instinct MI250X 128GB has 128.0 GB. With Q4_K_M quantization, expect ~36 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 94.1 GB, 36.2 tok/s, Runs well

94.1 GB required128.0 GB available

74% VRAM used

Fit status

Runs well

Decode

36.2 tok/s

TTFT

5351 ms

Safe context

117K

Memory

94.1 GB / 128.0 GB

Memory breakdown

Weights75.0 GB

KV Cache5.4 GB

Runtime0.9 GB

Headroom12.8 GB

See how fast it feels

See how fast it feelsDevstral 2 123B Instruct on AMD Instinct MI250X 128GB
1st promptCold start — includes initialization
>Write a Python function to sort a list
Here's a Python function that sorts a list using quicksort:

def quicksort(arr):
    if len(arr) <= 1:
        return arr
    pivot = arr[len(arr) // 2]
    left   = [x for x in arr if x < pivot]
    middle = [x for x in arr if x == pivot]
    right  = [x for x in arr if x > pivot]
    return quicksort(left) + middle + quicksort(right)

# Example usage
numbers = [3, 6, 8, 10, 1, 2, 1]
print(quicksort(numbers))  # [1, 1, 2, 3, 6, 8, 10]

The algorithm picks a pivot, partitions the list into smaller, equal, and larger elements, then recursively sorts each partition and concatenates the results.
2nd promptWarm — model ready, no init overhead
>Now add type hints and a docstring
def quicksort(arr: list[int]) -> list[int]:
    """Sort a list using the quicksort algorithm.

    Args:
        arr: List of integers to sort.

    Returns:
        A new sorted list.
    """
    if len(arr) <= 1:
        return arr
    pivot = arr[len(arr) // 2]
    left   = [x for x in arr if x < pivot]
    middle = [x for x in arr if x == pivot]
    right  = [x for x in arr if x > pivot]
    return quicksort(left) + middle + quicksort(right)

Added type hints for the input and return type, plus a Google-style docstring.
Estimated: 36.2 tok/s decode · 5.4s TTFT (warm) · 90 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	S	Runs well	36.2 tok/s	2919 ms	117K
Coding	S	Runs well	36.2 tok/s	5351 ms	117K
Agentic Coding	S	Runs well	36.2 tok/s	7784 ms	117K
Reasoning	S	Runs well	36.2 tok/s	6324 ms	117K
RAG	S	Runs well	36.2 tok/s	9730 ms	117K

Quantization options

How Devstral 2 123B Instruct (123B params) fits at each quantization level on AMD Instinct MI250X 128GB (128.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	48.0 GB	Low	S88
Q3_K_S	3	60.3 GB	Low	S90
NVFP4	4	68.9 GB	Medium	S91
Q4_K_M	4	75.0 GB	Medium	S91
Q5_K_M	5	88.6 GB	High	S91
Q6_KBest for your GPU	6	100.9 GB	High	S91
Q8_0	8	131.6 GB	Very High	F0
F16	16	252.2 GB	Maximum	F0

Get started

Copy-paste commands to run Devstral 2 123B Instruct on your machine.

Run

lms load Devstral-2-123B-Instruct-2512 && lms server start

Frequently asked questions

Can AMD Instinct MI250X 128GB run Devstral 2 123B Instruct?

Yes, AMD Instinct MI250X 128GB can run Devstral 2 123B Instruct with a S grade (Runs well). Expected decode speed: 36.2 tok/s.

How much VRAM does Devstral 2 123B Instruct need?

Devstral 2 123B Instruct (123B parameters) requires approximately 94.1 GB of memory with Q4_K_M quantization.

What is the best quantization for Devstral 2 123B Instruct?

The recommended quantization for Devstral 2 123B Instruct is Q4_K_M, which balances quality and memory efficiency.

What speed will Devstral 2 123B Instruct run at on AMD Instinct MI250X 128GB?

On AMD Instinct MI250X 128GB, Devstral 2 123B Instruct achieves approximately 36.2 tokens per second decode speed with a time-to-first-token of 5351ms using Q4_K_M quantization.

Can AMD Instinct MI250X 128GB run Devstral 2 123B Instruct for coding?

For coding workloads, Devstral 2 123B Instruct on AMD Instinct MI250X 128GB receives a S grade with 36.2 tok/s and 117K context.

What context window can Devstral 2 123B Instruct use on AMD Instinct MI250X 128GB?

On AMD Instinct MI250X 128GB, Devstral 2 123B Instruct can safely use up to 117K tokens of context. The model's official context limit is 256K, but available memory constrains the safe maximum.

See all results for AMD Instinct MI250X 128GB See all hardware for Devstral 2 123B Instruct

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Preview:

Workload

Grade

Fit

Decode

TTFT

Context

Chat

Runs well

36.2 tok/s

2919 ms

117K

Coding

Runs well

36.2 tok/s

5351 ms

117K

Agentic Coding

Runs well

36.2 tok/s

7784 ms

117K

Reasoning

Runs well

36.2 tok/s

6324 ms

117K

RAG

Runs well

36.2 tok/s

9730 ms

117K

Quantization options

How Devstral 2 123B Instruct (123B params) fits at each quantization level on AMD Instinct MI250X 128GB (128.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	48.0 GB	Low	S88
Q3_K_S	3	60.3 GB	Low	S90
NVFP4	4	68.9 GB	Medium	S91
Q4_K_M	4	75.0 GB	Medium	S91
Q5_K_M	5	88.6 GB	High	S91
Q6_KBest for your GPU	6	100.9 GB	High	S91
Q8_0	8	131.6 GB	Very High	F0
F16	16	252.2 GB	Maximum	F0

Frequently asked questions

Can AMD Instinct MI250X 128GB run Devstral 2 123B Instruct?

Yes, AMD Instinct MI250X 128GB can run Devstral 2 123B Instruct with a S grade (Runs well). Expected decode speed: 36.2 tok/s.

How much VRAM does Devstral 2 123B Instruct need?

Devstral 2 123B Instruct (123B parameters) requires approximately 94.1 GB of memory with Q4_K_M quantization.

What is the best quantization for Devstral 2 123B Instruct?

The recommended quantization for Devstral 2 123B Instruct is Q4_K_M, which balances quality and memory efficiency.

What speed will Devstral 2 123B Instruct run at on AMD Instinct MI250X 128GB?

On AMD Instinct MI250X 128GB, Devstral 2 123B Instruct achieves approximately 36.2 tokens per second decode speed with a time-to-first-token of 5351ms using Q4_K_M quantization.

Can AMD Instinct MI250X 128GB run Devstral 2 123B Instruct for coding?

For coding workloads, Devstral 2 123B Instruct on AMD Instinct MI250X 128GB receives a S grade with 36.2 tok/s and 117K context.

What context window can Devstral 2 123B Instruct use on AMD Instinct MI250X 128GB?

On AMD Instinct MI250X 128GB, Devstral 2 123B Instruct can safely use up to 117K tokens of context. The model's official context limit is 256K, but available memory constrains the safe maximum.