Can Gemma 3 27B run on AMD Instinct MI250 128GB?

YES — Runs Great

A81Great

Estimated from fit model

Gemma 3 27B needs ~41.4 GB VRAM. AMD Instinct MI250 128GB has 128.0 GB. With Q4_K_M quantization, expect ~86 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 41.4 GB, 86.2 tok/s, Runs well

41.4 GB required128.0 GB available

32% VRAM used

Fit status

Runs well

Decode

86.2 tok/s

TTFT

2246 ms

Safe context

131K

Memory

41.4 GB / 128.0 GB

Memory breakdown

Weights16.5 GB

KV Cache11.2 GB

Runtime0.9 GB

Headroom12.8 GB

See how fast it feels

See how fast it feelsGemma 3 27B on AMD Instinct MI250 128GB
1st promptCold start — includes initialization
>Write a Python function to sort a list
Here's a Python function that sorts a list using quicksort:

def quicksort(arr):
    if len(arr) <= 1:
        return arr
    pivot = arr[len(arr) // 2]
    left   = [x for x in arr if x < pivot]
    middle = [x for x in arr if x == pivot]
    right  = [x for x in arr if x > pivot]
    return quicksort(left) + middle + quicksort(right)

# Example usage
numbers = [3, 6, 8, 10, 1, 2, 1]
print(quicksort(numbers))  # [1, 1, 2, 3, 6, 8, 10]

The algorithm picks a pivot, partitions the list into smaller, equal, and larger elements, then recursively sorts each partition and concatenates the results.
2nd promptWarm — model ready, no init overhead
>Now add type hints and a docstring
def quicksort(arr: list[int]) -> list[int]:
    """Sort a list using the quicksort algorithm.

    Args:
        arr: List of integers to sort.

    Returns:
        A new sorted list.
    """
    if len(arr) <= 1:
        return arr
    pivot = arr[len(arr) // 2]
    left   = [x for x in arr if x < pivot]
    middle = [x for x in arr if x == pivot]
    right  = [x for x in arr if x > pivot]
    return quicksort(left) + middle + quicksort(right)

Added type hints for the input and return type, plus a Google-style docstring.
Estimated: 86.2 tok/s decode · 2.2s TTFT (warm) · 216 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	A	Runs well	86.2 tok/s	1225 ms	131K
Coding	A	Runs well	86.2 tok/s	2246 ms	131K
Agentic Coding	A	Runs well	86.2 tok/s	3266 ms	131K
Reasoning	A	Runs well	86.2 tok/s	2654 ms	131K
RAG	A	Runs well	86.2 tok/s	4083 ms	131K

Quantization options

How Gemma 3 27B (27B params) fits at each quantization level on AMD Instinct MI250 128GB (128.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	10.5 GB	Low	A71
Q3_K_S	3	13.2 GB	Low	A71
NVFP4	4	15.1 GB	Medium	A71
Q4_K_M	4	16.5 GB	Medium	A71
Q5_K_M	5	19.4 GB	High	A72
Q6_K	6	22.1 GB	High	A72
Q8_0	8	28.9 GB	Very High	A73
F16Best for your GPU	16	55.4 GB	Maximum	A77

Get started

Copy-paste commands to run Gemma 3 27B on your machine.

Run

ollama run gemma3

Your hardware

More models your AMD Instinct MI250 128GB can run

Model	Params	Grade	Decode
Devstral 2 123B Instruct	123B	S	31.5 tok/s
Qwen3-Coder 30B A3B Instruct	30.5B	S	329 tok/s
Qwen 3.5 122B A10B	122B	S	87.5 tok/s
Qwen 3.6 35B A3B	35B	S	276.5 tok/s
Qwen3-VL 30B A3B Instruct	30B	S	340.3 tok/s

Frequently asked questions

Can AMD Instinct MI250 128GB run Gemma 3 27B?

Yes, AMD Instinct MI250 128GB can run Gemma 3 27B with a A grade (Runs well). Expected decode speed: 86.2 tok/s.

How much VRAM does Gemma 3 27B need?

Gemma 3 27B (27B parameters) requires approximately 41.4 GB of memory with Q4_K_M quantization.

What is the best quantization for Gemma 3 27B?

The recommended quantization for Gemma 3 27B is Q4_K_M, which balances quality and memory efficiency.

What speed will Gemma 3 27B run at on AMD Instinct MI250 128GB?

On AMD Instinct MI250 128GB, Gemma 3 27B achieves approximately 86.2 tokens per second decode speed with a time-to-first-token of 2246ms using Q4_K_M quantization.

Can AMD Instinct MI250 128GB run Gemma 3 27B for coding?

For coding workloads, Gemma 3 27B on AMD Instinct MI250 128GB receives a A grade with 86.2 tok/s and 131K context.

What context window can Gemma 3 27B use on AMD Instinct MI250 128GB?

On AMD Instinct MI250 128GB, Gemma 3 27B can safely use up to 131K tokens of context. The model's official context limit is 131K, but available memory constrains the safe maximum.

See all results for AMD Instinct MI250 128GB See all hardware for Gemma 3 27B

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