Devstral 2 123B Instruct needs ~94.1 GB VRAM. AMD Instinct MI250 128GB has 128.0 GB. With Q4_K_M quantization, expect ~32 tok/s.
Operating mode
Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.
Current mode
Balanced
Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.
Select quantization to explore
Fit status
Runs well
Decode
31.5 tok/s
TTFT
6138 ms
Safe context
117K
Memory
94.1 GB / 128.0 GB
This setup is broadly balanced for this model.
No major red flags
This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.
| Workload | Grade | Fit | Decode | TTFT | Context |
|---|---|---|---|---|---|
| Chat | S | Runs well | 31.5 tok/s | 3348 ms | 117K |
| Coding | S | Runs well | 31.5 tok/s | 6138 ms | 117K |
| Agentic Coding | S | Runs well | 31.5 tok/s | 8929 ms | 117K |
| Reasoning | S | Runs well | 31.5 tok/s | 7254 ms | 117K |
| RAG | S | Runs well | 31.5 tok/s | 11161 ms | 117K |
How Devstral 2 123B Instruct (123B params) fits at each quantization level on AMD Instinct MI250 128GB (128.0 GB usable).
| Quant | Bits | VRAM | Quality | Fit |
|---|---|---|---|---|
Q2_K | 2 | 48.0 GB | Low | S88 |
Q3_K_S | 3 | 60.3 GB | Low | S90 |
NVFP4 | 4 |
Copy-paste commands to run Devstral 2 123B Instruct on your machine.
Run
lms load Devstral-2-123B-Instruct-2512 && lms server startYes, AMD Instinct MI250 128GB can run Devstral 2 123B Instruct with a S grade (Runs well). Expected decode speed: 31.5 tok/s.
Devstral 2 123B Instruct (123B parameters) requires approximately 94.1 GB of memory with Q4_K_M quantization.
The recommended quantization for Devstral 2 123B Instruct is Q4_K_M, which balances quality and memory efficiency.
On AMD Instinct MI250 128GB, Devstral 2 123B Instruct achieves approximately 31.5 tokens per second decode speed with a time-to-first-token of 6138ms using Q4_K_M quantization.
For coding workloads, Devstral 2 123B Instruct on AMD Instinct MI250 128GB receives a S grade with 31.5 tok/s and 117K context.
On AMD Instinct MI250 128GB, Devstral 2 123B Instruct can safely use up to 117K tokens of context. The model's official context limit is 256K, but available memory constrains the safe maximum.
Paste this snippet into any page to show a live fit card.
<iframe src="https://willitrunai.com/embed/devstral-2-123b-on-instinct-mi250-128gb" width="400" height="180" frameborder="0" style="border:none;border-radius:12px;overflow:hidden;" title="Will It Run AI — fit result"></iframe>
Preview:
68.9 GB |
| Medium |
| S91 |
Q4_K_M | 4 | 75.0 GB | Medium | S91 |
Q5_K_M | 5 | 88.6 GB | High | S91 |
Q6_KBest for your GPU | 6 | 100.9 GB | High | S91 |
Q8_0 | 8 | 131.6 GB | Very High | F0 |
F16 | 16 | 252.2 GB | Maximum | F0 |