Can Qwen 2.5 72B run on AMD Instinct MI250 128GB?

YES — Runs Great

A82Great

Estimated from fit model

Qwen 2.5 72B needs ~62.5 GB VRAM. AMD Instinct MI250 128GB has 128.0 GB. With Q4_K_M quantization, expect ~54 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 62.5 GB, 53.9 tok/s, Runs well

62.5 GB required128.0 GB available

49% VRAM used

Fit status

Runs well

Decode

53.9 tok/s

TTFT

3593 ms

Safe context

131K

Memory

62.5 GB / 128.0 GB

Memory breakdown

Weights43.9 GB

KV Cache4.9 GB

Runtime0.9 GB

Headroom12.8 GB

See how fast it feels

See how fast it feelsQwen 2.5 72B on AMD Instinct MI250 128GB
1st promptCold start — includes initialization
>Solve: If a train travels at 60 mph for 2.5 hours, how far does it go?
Let me work through this step by step.

Given information:
  - Speed = 60 mph (miles per hour)
  - Time  = 2.5 hours

Formula: Distance = Speed x Time

Calculation:
  Distance = 60 mph x 2.5 h
           = 150 miles

The train travels 150 miles.

Double-check: at 60 mph the train covers 60 miles each hour. In half an hour it covers 30 miles. So in 2.5 hours: 60 + 60 + 30 = 150 miles. Confirmed.
2nd promptWarm — model ready, no init overhead
>What if the train stops for 20 minutes halfway?
The stop doesn't change the total distance covered while moving, but it affects total trip time.

Breakdown:
  - First half: 1.25 hours at 60 mph = 75 miles
  - Stop: 20 minutes (no distance)
  - Second half: 1.25 hours at 60 mph = 75 miles

Total distance: 150 miles (same)
Total time: 2.5 h + 0.33 h = 2.83 hours
Average speed: 150 / 2.83 = 53 mph

The distance stays the same but average speed drops to 53 mph because of the stop.
Estimated: 53.9 tok/s decode · 3.6s TTFT (warm) · 135 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	A	Runs well	53.9 tok/s	1960 ms	131K
Coding	A	Runs well	53.9 tok/s	3593 ms	131K
Agentic Coding	A	Runs well	53.9 tok/s	5226 ms	131K
Reasoning	A	Runs well	53.9 tok/s	4246 ms	131K
RAG	A	Runs well	53.9 tok/s	6533 ms	131K

Quantization options

How Qwen 2.5 72B (72B params) fits at each quantization level on AMD Instinct MI250 128GB (128.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	28.1 GB	Low	A72
Q3_K_S	3	35.3 GB	Low	A73
NVFP4	4	40.3 GB	Medium	A74
Q4_K_M	4	43.9 GB	Medium	A74
Q5_K_M	5	51.8 GB	High	A76
Q6_K	6	59.0 GB	High	A77
Q8_0Best for your GPU	8	77.0 GB	Very High	A79
F16	16	147.6 GB	Maximum	F0

Get started

Copy-paste commands to run Qwen 2.5 72B on your machine.

Run

ollama run qwen2.5:72b

Your hardware

More models your AMD Instinct MI250 128GB can run

Model	Params	Grade	Decode
Devstral 2 123B Instruct	123B	S	31.5 tok/s
Qwen 3.5 122B A10B	122B	S	87.5 tok/s
Mistral Small 4 119B	119B	S	94.8 tok/s
GPT-OSS 120B	117B	S	33.2 tok/s
Command A 111B	111B	S	35.1 tok/s

Frequently asked questions

Can AMD Instinct MI250 128GB run Qwen 2.5 72B?

Yes, AMD Instinct MI250 128GB can run Qwen 2.5 72B with a A grade (Runs well). Expected decode speed: 53.9 tok/s.

How much VRAM does Qwen 2.5 72B need?

Qwen 2.5 72B (72B parameters) requires approximately 62.5 GB of memory with Q4_K_M quantization.

What is the best quantization for Qwen 2.5 72B?

The recommended quantization for Qwen 2.5 72B is Q4_K_M, which balances quality and memory efficiency.

What speed will Qwen 2.5 72B run at on AMD Instinct MI250 128GB?

On AMD Instinct MI250 128GB, Qwen 2.5 72B achieves approximately 53.9 tokens per second decode speed with a time-to-first-token of 3593ms using Q4_K_M quantization.

Can AMD Instinct MI250 128GB run Qwen 2.5 72B for coding?

For coding workloads, Qwen 2.5 72B on AMD Instinct MI250 128GB receives a A grade with 53.9 tok/s and 131K context.

What context window can Qwen 2.5 72B use on AMD Instinct MI250 128GB?

On AMD Instinct MI250 128GB, Qwen 2.5 72B can safely use up to 131K tokens of context. The model's official context limit is 131K, but available memory constrains the safe maximum.

See all results for AMD Instinct MI250 128GB See all hardware for Qwen 2.5 72B

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