Can MPT-30B-Instruct run on AMD Instinct MI250X 128GB?

YES — Runs Great

A72Great

Estimated from fit model

MPT-30B-Instruct needs ~59.0 GB VRAM. AMD Instinct MI250X 128GB has 128.0 GB. With Q5_K_M quantization, expect ~118 tok/s.

Runtime: OllamaCapacity: RoomyBandwidth: HighStack: BasicBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q5_K_M (High quality) — 59.0 GB, 117.9 tok/s, Runs well

59.0 GB required128.0 GB available

46% VRAM used

Fit status

Runs well

Decode

117.9 tok/s

TTFT

1643 ms

Safe context

Memory

59.0 GB / 128.0 GB

Memory breakdown

Weights21.6 GB

KV Cache23.4 GB

Runtime1.2 GB

Headroom12.8 GB

See how fast it feels

See how fast it feelsMPT-30B-Instruct on AMD Instinct MI250X 128GB
1st promptCold start — includes initialization
>Solve: If a train travels at 60 mph for 2.5 hours, how far does it go?
Let me work through this step by step.

Given information:
  - Speed = 60 mph (miles per hour)
  - Time  = 2.5 hours

Formula: Distance = Speed x Time

Calculation:
  Distance = 60 mph x 2.5 h
           = 150 miles

The train travels 150 miles.

Double-check: at 60 mph the train covers 60 miles each hour. In half an hour it covers 30 miles. So in 2.5 hours: 60 + 60 + 30 = 150 miles. Confirmed.
2nd promptWarm — model ready, no init overhead
>What if the train stops for 20 minutes halfway?
The stop doesn't change the total distance covered while moving, but it affects total trip time.

Breakdown:
  - First half: 1.25 hours at 60 mph = 75 miles
  - Stop: 20 minutes (no distance)
  - Second half: 1.25 hours at 60 mph = 75 miles

Total distance: 150 miles (same)
Total time: 2.5 h + 0.33 h = 2.83 hours
Average speed: 150 / 2.83 = 53 mph

The distance stays the same but average speed drops to 53 mph because of the stop.
Estimated: 117.9 tok/s decode · 1.6s TTFT (warm) · 295 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	A	Runs well	117.9 tok/s	896 ms	8K
Coding	A	Runs well	117.9 tok/s	1643 ms	8K
Agentic Coding	A	Runs well	117.9 tok/s	2389 ms	8K
Reasoning	A	Runs well	117.9 tok/s	1941 ms	8K
RAG	A	Runs well	117.9 tok/s	2986 ms	8K

Quantization options

How MPT-30B-Instruct (30B params) fits at each quantization level on AMD Instinct MI250X 128GB (128.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	11.7 GB	Low	B59
Q3_K_S	3	14.7 GB	Low	B59
NVFP4	4	16.8 GB	Medium	B59
Q4_K_M	4	18.3 GB	Medium	B60
Q5_K_M	5	21.6 GB	High	B60
Q6_K	6	24.6 GB	High	B60
Q8_0	8	32.1 GB	Very High	B61
F16Best for your GPU	16	61.5 GB	Maximum	B66

Get started

Copy-paste commands to run MPT-30B-Instruct on your machine.

Run

docker run --rm -it ghcr.io/ggerganov/llama.cpp:full \
  --hf-repo "mosaicml/mpt-30b-instruct" \
  --hf-file "mpt-30b-instruct-Q5_K_M.gguf" \
  -c 4096 -ngl 99

Your hardware

More models your AMD Instinct MI250X 128GB can run

Model	Params	Grade	Decode
Devstral 2 123B Instruct	123B	S	36.2 tok/s
Qwen3-Coder 30B A3B Instruct	30.5B	S	377.4 tok/s
Qwen 3.5 122B A10B	122B	S	100.3 tok/s
Qwen 3.6 35B A3B	35B	S	317.2 tok/s
Qwen 3.5 35B A3B	35B	S	344.9 tok/s

Frequently asked questions

Can AMD Instinct MI250X 128GB run MPT-30B-Instruct?

Yes, AMD Instinct MI250X 128GB can run MPT-30B-Instruct with a A grade (Runs well). Expected decode speed: 117.9 tok/s.

How much VRAM does MPT-30B-Instruct need?

MPT-30B-Instruct (30B parameters) requires approximately 59.0 GB of memory with Q5_K_M quantization.

What is the best quantization for MPT-30B-Instruct?

The recommended quantization for MPT-30B-Instruct is Q5_K_M, which balances quality and memory efficiency.

What speed will MPT-30B-Instruct run at on AMD Instinct MI250X 128GB?

On AMD Instinct MI250X 128GB, MPT-30B-Instruct achieves approximately 117.9 tokens per second decode speed with a time-to-first-token of 1643ms using Q5_K_M quantization.

Can AMD Instinct MI250X 128GB run MPT-30B-Instruct for coding?

For coding workloads, MPT-30B-Instruct on AMD Instinct MI250X 128GB receives a A grade with 117.9 tok/s and 8K context.

What context window can MPT-30B-Instruct use on AMD Instinct MI250X 128GB?

On AMD Instinct MI250X 128GB, MPT-30B-Instruct can safely use up to 8K tokens of context. The model's official context limit is 8K, but available memory constrains the safe maximum.

See all results for AMD Instinct MI250X 128GB See all hardware for MPT-30B-Instruct

Embed this result▼

Paste this snippet into any page to show a live fit card.

<iframe src="https://willitrunai.com/embed/mpt-30b-instruct-on-instinct-mi250x-128gb" width="400" height="180" frameborder="0" style="border:none;border-radius:12px;overflow:hidden;" title="Will It Run AI — fit result"></iframe>

Preview: