Can MiniCPM-V 2.6 8B run on AMD Instinct MI250X 128GB?

YES — Runs Great

A76Great

Estimated from fit model

MiniCPM-V 2.6 8B needs ~20.5 GB VRAM. AMD Instinct MI250X 128GB has 128.0 GB. With Q4_K_M quantization, expect ~112 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 20.5 GB, 112.0 tok/s, Runs well

20.5 GB required128.0 GB available

16% VRAM used

Fit status

Runs well

Decode

112.0 tok/s

TTFT

1729 ms

Safe context

Memory

20.5 GB / 128.0 GB

Memory breakdown

Weights4.9 GB

KV Cache2.0 GB

Runtime0.9 GB

Headroom12.8 GB

See how fast it feels

See how fast it feelsMiniCPM-V 2.6 8B on AMD Instinct MI250X 128GB
1st promptCold start — includes initialization
>What is local AI inference?
Local AI inference means running an AI language model directly on your own hardware — your laptop, desktop, or server — instead of sending requests to a remote cloud API.

When you run inference locally the model weights are loaded into your GPU or unified memory. Each token you generate requires reading those weights from memory, so memory bandwidth is the main bottleneck for decode speed.

Key benefits of running locally:
  - Full privacy: your prompts never leave your machine
  - No per-token cost or rate limits
  - Works offline once the model is downloaded
  - Latency depends only on your hardware
2nd promptWarm — model ready, no init overhead
>How much VRAM do I need?
It depends on the model size and quantization level. A rough rule of thumb:

  Model size     Q4 (4-bit)    Q8 (8-bit)    FP16
  7B params      ~4.3 GB       ~7.5 GB       ~14 GB
  13B params     ~7.9 GB       ~13.9 GB      ~26 GB
  70B params     ~42.7 GB      ~74.9 GB      ~140 GB

Most people use 4-bit quantization (Q4_K_M) which gives 90-95% of full quality at a fraction of the memory. A 24 GB GPU can comfortably run most 7B-13B models.
Estimated: 112.0 tok/s decode · 1.7s TTFT (warm) · 280 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	A	Runs well	112.0 tok/s	943 ms	2K
Coding	A	Runs well	112.0 tok/s	1729 ms	2K
Agentic Coding	A	Runs well	112.0 tok/s	2514 ms	2K
Reasoning	A	Runs well	112.0 tok/s	2043 ms	2K
RAG	A	Runs well	112.0 tok/s	3143 ms	2K

Inference speed

MiniCPM-V 2.6 8B inference speed — tokens per second by GPU & Mac

Estimated decode speed (tokens/sec) for MiniCPM-V 2.6 8B at Q4_K_M across popular GPUs and Apple Silicon, using the fastest local runtime per device. Fastest is RTX 5090 32GB at ~112 tok/s. Speed is memory-bandwidth bound, so cards that fit the whole model in VRAM run far faster than ones that offload to system RAM.

GPU / Mac	Memory	Quant	Speed (tok/s)	Fits?
RTX 5090 32GB	32 GB	Q4_K_M	112.0	Fits
RTX 4090 24GB	24 GB	Q4_K_M	112.0	Fits
RTX 4080 Super 16GB	16 GB	Q4_K_M	112.0	Fits
RTX 3090 24GB	24 GB	Q4_K_M	112.0	Fits
RX 7900 XTX 24GB	24 GB	Q4_K_M	112.0	Fits
Mac Studio M3 Ultra 256GB	256 GB	Q4_K_M	112.0	Fits
Mac Studio M2 Ultra 128GB	128 GB	Q4_K_M	102.2	Fits
Mac Studio M1 Ultra 128GB	128 GB	Q4_K_M	96.9	Fits
RTX 4070 12GB	12 GB	Q4_K_M	83.3	Fits
MacBook Pro M4 Max 128GB	128 GB	Q4_K_M	82.6	Fits
MacBook Pro M4 Max 64GB	64 GB	Q4_K_M	82.6	Fits
MacBook Pro M3 Max 64GB	64 GB	Q4_K_M	52.9	Fits
RTX 3060 12GB	12 GB	Q4_K_M	52.3	Fits
MacBook Pro M1 Max 64GB	64 GB	Q4_K_M	48.5	Fits
MacBook Pro M4 Pro 48GB	48 GB	Q4_K_M	42.6	Fits
RTX 4060 8GB	8 GB	Q4_K_M	26.6	Heavy offload

Estimates for single-stream decoding at Q4_K_M; real tokens/sec varies with prompt length, context, batch size, and runtime build. Prompt processing (prefill) is faster than the decode figures shown here.

Quantization options

How MiniCPM-V 2.6 8B (8B params) fits at each quantization level on AMD Instinct MI250X 128GB (128.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	3.1 GB	Low	B69
Q3_K_S	3	3.9 GB	Low	B69
NVFP4	4	4.5 GB	Medium	B69
Q4_K_M	4	4.9 GB	Medium	B69
Q5_K_M	5	5.8 GB	High	B69
Q6_K	6	6.6 GB	High	B69
Q8_0	8	8.6 GB	Very High	B69
F16Best for your GPU	16	16.4 GB	Maximum	B69

Get started

Copy-paste commands to run MiniCPM-V 2.6 8B on your machine.

Run

docker run --rm -it ghcr.io/ggerganov/llama.cpp:full \
  --hf-repo "openbmb/MiniCPM-V-2_6" \
  --hf-file "MiniCPM-V-2_6-Q4_K_M.gguf" \
  -c 4096 -ngl 99

Your hardware

More models your AMD Instinct MI250X 128GB can run

Model	Params	Grade	Decode
Devstral 2 123B Instruct	123B	S	36.2 tok/s
Qwen3-Coder 30B A3B Instruct	30.5B	S	377.4 tok/s
Qwen 3.5 27B	27B	S	163.7 tok/s
Qwen 3.6 27B	27B	S	102 tok/s
Qwen 3.5 122B A10B	122B	S	100.3 tok/s

Frequently asked questions

Can AMD Instinct MI250X 128GB run MiniCPM-V 2.6 8B?

Yes, AMD Instinct MI250X 128GB can run MiniCPM-V 2.6 8B with a A grade (Runs well). Expected decode speed: 112.0 tok/s.

How much VRAM does MiniCPM-V 2.6 8B need?

MiniCPM-V 2.6 8B (8B parameters) requires approximately 20.5 GB of memory with Q4_K_M quantization.

What is the best quantization for MiniCPM-V 2.6 8B?

The recommended quantization for MiniCPM-V 2.6 8B is Q4_K_M, which balances quality and memory efficiency.

What speed will MiniCPM-V 2.6 8B run at on AMD Instinct MI250X 128GB?

On AMD Instinct MI250X 128GB, MiniCPM-V 2.6 8B achieves approximately 112.0 tokens per second decode speed with a time-to-first-token of 1729ms using Q4_K_M quantization.

Can AMD Instinct MI250X 128GB run MiniCPM-V 2.6 8B for coding?

For coding workloads, MiniCPM-V 2.6 8B on AMD Instinct MI250X 128GB receives a A grade with 112.0 tok/s and 2K context.

What context window can MiniCPM-V 2.6 8B use on AMD Instinct MI250X 128GB?

On AMD Instinct MI250X 128GB, MiniCPM-V 2.6 8B can safely use up to 2K tokens of context. The model's official context limit is 2K, but available memory constrains the safe maximum.

See all results for AMD Instinct MI250X 128GB See all hardware for MiniCPM-V 2.6 8B

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