Can Gemma 4 12B run on AMD Instinct MI325X 256GB?

YES — Runs Great

A77Great

Estimated from fit model

Gemma 4 12B needs ~39.7 GB VRAM. AMD Instinct MI325X 256GB has 256.0 GB. With Q4_K_M quantization, expect ~168 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 39.7 GB, 168.0 tok/s, Runs well

39.7 GB required256.0 GB available

16% VRAM used

Fit status

Runs well

Decode

168.0 tok/s

TTFT

1152 ms

Safe context

262K

Memory

39.7 GB / 256.0 GB

Memory breakdown

Weights7.3 GB

KV Cache5.9 GB

Runtime0.9 GB

Headroom25.6 GB

See how fast it feels

See how fast it feelsGemma 4 12B on AMD Instinct MI325X 256GB
1st promptCold start — includes initialization
>Write a Python function to sort a list
Here's a Python function that sorts a list using quicksort:

def quicksort(arr):
    if len(arr) <= 1:
        return arr
    pivot = arr[len(arr) // 2]
    left   = [x for x in arr if x < pivot]
    middle = [x for x in arr if x == pivot]
    right  = [x for x in arr if x > pivot]
    return quicksort(left) + middle + quicksort(right)

# Example usage
numbers = [3, 6, 8, 10, 1, 2, 1]
print(quicksort(numbers))  # [1, 1, 2, 3, 6, 8, 10]

The algorithm picks a pivot, partitions the list into smaller, equal, and larger elements, then recursively sorts each partition and concatenates the results.
2nd promptWarm — model ready, no init overhead
>Now add type hints and a docstring
def quicksort(arr: list[int]) -> list[int]:
    """Sort a list using the quicksort algorithm.

    Args:
        arr: List of integers to sort.

    Returns:
        A new sorted list.
    """
    if len(arr) <= 1:
        return arr
    pivot = arr[len(arr) // 2]
    left   = [x for x in arr if x < pivot]
    middle = [x for x in arr if x == pivot]
    right  = [x for x in arr if x > pivot]
    return quicksort(left) + middle + quicksort(right)

Added type hints for the input and return type, plus a Google-style docstring.
Estimated: 168.0 tok/s decode · 1.2s TTFT (warm) · 420 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	A	Runs well	168.0 tok/s	629 ms	262K
Coding	A	Runs well	168.0 tok/s	1152 ms	262K
Agentic Coding	A	Runs well	168.0 tok/s	1676 ms	262K
Reasoning	A	Runs well	168.0 tok/s	1362 ms	262K
RAG	A	Runs well	168.0 tok/s	2095 ms	262K

Inference speed

Gemma 4 12B inference speed — tokens per second by GPU & Mac

Estimated decode speed (tokens/sec) for Gemma 4 12B at Q4_K_M across popular GPUs and Apple Silicon, using the fastest local runtime per device. Fastest is RTX 5090 32GB at ~168 tok/s. Speed is memory-bandwidth bound, so cards that fit the whole model in VRAM run far faster than ones that offload to system RAM.

GPU / Mac	Memory	Quant	Speed (tok/s)	Fits?
RTX 5090 32GB	32 GB	Q4_K_M	168.0	Fits
RTX 4090 24GB	24 GB	Q4_K_M	109.9	Fits
RX 7900 XTX 24GB	24 GB	Q4_K_M	99.1	Fits
RTX 3090 24GB	24 GB	Q4_K_M	94.0	Fits
RTX 4080 Super 16GB	16 GB	Q4_K_M	87.6	Offloads
Mac Studio M3 Ultra 256GB	256 GB	Q4_K_M	60.5	Fits
Mac Studio M2 Ultra 128GB	128 GB	Q4_K_M	50.4	Fits
Mac Studio M1 Ultra 128GB	128 GB	Q4_K_M	47.8	Fits
MacBook Pro M4 Max 64GB	64 GB	Q4_K_M	43.4	Fits
MacBook Pro M3 Max 64GB	64 GB	Q4_K_M	34.4	Fits
MacBook Pro M4 Max 128GB	128 GB	Q4_K_M	32.9	Fits
MacBook Pro M1 Max 64GB	64 GB	Q4_K_M	31.6	Fits
MacBook Pro M4 Pro 48GB	48 GB	Q4_K_M	26.5	Fits
RTX 4070 12GB	12 GB	Q4_K_M	23.5	Too big
RTX 3060 12GB	12 GB	Q4_K_M	14.8	Too big
RTX 4060 8GB	8 GB	Q4_K_M	5.5	Too big

Estimates for single-stream decoding at Q4_K_M; real tokens/sec varies with prompt length, context, batch size, and runtime build. Prompt processing (prefill) is faster than the decode figures shown here.

Quantization options

How Gemma 4 12B (12B params) fits at each quantization level on AMD Instinct MI325X 256GB (256.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	4.7 GB	Low	B68
Q3_K_S	3	5.9 GB	Low	B68
NVFP4	4	6.7 GB	Medium	B68
Q4_K_M	4	7.3 GB	Medium	B68
Q5_K_M	5	8.6 GB	High	B68
Q6_K	6	9.8 GB	High	B68
Q8_0	8	12.8 GB	Very High	B68
F16Best for your GPU	16	24.6 GB	Maximum	B69

Get started

Copy-paste commands to run Gemma 4 12B on your machine.

Run

lms load gemma-4-12B-it && lms server start

Your hardware

More models your AMD Instinct MI325X 256GB can run

Model	Params	Grade	Decode
Qwen 3.5 397B A17B	397B	A	39.2 tok/s
Devstral 2 123B Instruct	123B	S	63.5 tok/s
Qwen3-Coder 30B A3B Instruct	30.5B	S	662.3 tok/s
Qwen 3.5 27B	27B	S	287.2 tok/s
Qwen 3.6 27B	27B	S	179 tok/s

Frequently asked questions

Can AMD Instinct MI325X 256GB run Gemma 4 12B?

Yes, AMD Instinct MI325X 256GB can run Gemma 4 12B with a A grade (Runs well). Expected decode speed: 168.0 tok/s.

How much VRAM does Gemma 4 12B need?

Gemma 4 12B (12B parameters) requires approximately 39.7 GB of memory with Q4_K_M quantization.

What is the best quantization for Gemma 4 12B?

The recommended quantization for Gemma 4 12B is Q4_K_M, which balances quality and memory efficiency.

What speed will Gemma 4 12B run at on AMD Instinct MI325X 256GB?

On AMD Instinct MI325X 256GB, Gemma 4 12B achieves approximately 168.0 tokens per second decode speed with a time-to-first-token of 1152ms using Q4_K_M quantization.

Can AMD Instinct MI325X 256GB run Gemma 4 12B for coding?

For coding workloads, Gemma 4 12B on AMD Instinct MI325X 256GB receives a A grade with 168.0 tok/s and 262K context.

What context window can Gemma 4 12B use on AMD Instinct MI325X 256GB?

On AMD Instinct MI325X 256GB, Gemma 4 12B can safely use up to 262K tokens of context. The model's official context limit is 262K, but available memory constrains the safe maximum.

See all results for AMD Instinct MI325X 256GB See all hardware for Gemma 4 12B

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