Can Qwen 3.5 27B run on AMD Instinct MI325X 256GB?

YES — Runs Great

S88Excellent

Estimated from fit model

Qwen 3.5 27B needs ~46.1 GB VRAM. AMD Instinct MI325X 256GB has 256.0 GB. With Q4_K_M quantization, expect ~287 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 46.1 GB, 287.2 tok/s, Runs well

46.1 GB required256.0 GB available

18% VRAM used

Fit status

Runs well

Decode

287.2 tok/s

TTFT

674 ms

Safe context

131K

Memory

46.1 GB / 256.0 GB

Memory breakdown

Weights16.5 GB

KV Cache3.2 GB

Runtime0.9 GB

Headroom25.6 GB

See how fast it feels

See how fast it feelsQwen 3.5 27B on AMD Instinct MI325X 256GB
1st promptCold start — includes initialization
>Write a Python function to sort a list
Here's a Python function that sorts a list using quicksort:

def quicksort(arr):
    if len(arr) <= 1:
        return arr
    pivot = arr[len(arr) // 2]
    left   = [x for x in arr if x < pivot]
    middle = [x for x in arr if x == pivot]
    right  = [x for x in arr if x > pivot]
    return quicksort(left) + middle + quicksort(right)

# Example usage
numbers = [3, 6, 8, 10, 1, 2, 1]
print(quicksort(numbers))  # [1, 1, 2, 3, 6, 8, 10]

The algorithm picks a pivot, partitions the list into smaller, equal, and larger elements, then recursively sorts each partition and concatenates the results.
2nd promptWarm — model ready, no init overhead
>Now add type hints and a docstring
def quicksort(arr: list[int]) -> list[int]:
    """Sort a list using the quicksort algorithm.

    Args:
        arr: List of integers to sort.

    Returns:
        A new sorted list.
    """
    if len(arr) <= 1:
        return arr
    pivot = arr[len(arr) // 2]
    left   = [x for x in arr if x < pivot]
    middle = [x for x in arr if x == pivot]
    right  = [x for x in arr if x > pivot]
    return quicksort(left) + middle + quicksort(right)

Added type hints for the input and return type, plus a Google-style docstring.
Estimated: 287.2 tok/s decode · 674ms TTFT (warm) · 718 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	S	Runs well	287.2 tok/s	368 ms	131K
Coding	S	Runs well	287.2 tok/s	674 ms	131K
Agentic Coding	S	Runs well	287.2 tok/s	980 ms	131K
Reasoning	S	Runs well	287.2 tok/s	797 ms	131K
RAG	S	Runs well	287.2 tok/s	1226 ms	131K

Quantization options

How Qwen 3.5 27B (27B params) fits at each quantization level on AMD Instinct MI325X 256GB (256.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	10.5 GB	Low	A79
Q3_K_S	3	13.2 GB	Low	A79
NVFP4	4	15.1 GB	Medium	A79
Q4_K_M	4	16.5 GB	Medium	A79
Q5_K_M	5	19.4 GB	High	A79
Q6_K	6	22.1 GB	High	A80
Q8_0	8	28.9 GB	Very High	A80
F16Best for your GPU	16	55.4 GB	Maximum	A82

Get started

Copy-paste commands to run Qwen 3.5 27B on your machine.

Run

ollama run qwen3.5:27b

Your hardware

More models your AMD Instinct MI325X 256GB can run

Model	Params	Grade	Decode
Qwen 3.5 397B A17B	397B	A	39.2 tok/s
Devstral 2 123B Instruct	123B	S	63.5 tok/s
Qwen3-Coder 30B A3B Instruct	30.5B	S	662.3 tok/s

Frequently asked questions

Can AMD Instinct MI325X 256GB run Qwen 3.5 27B?

Yes, AMD Instinct MI325X 256GB can run Qwen 3.5 27B with a S grade (Runs well). Expected decode speed: 287.2 tok/s.

How much VRAM does Qwen 3.5 27B need?

Qwen 3.5 27B (27B parameters) requires approximately 46.1 GB of memory with Q4_K_M quantization.

What is the best quantization for Qwen 3.5 27B?

The recommended quantization for Qwen 3.5 27B is Q4_K_M, which balances quality and memory efficiency.

What speed will Qwen 3.5 27B run at on AMD Instinct MI325X 256GB?

On AMD Instinct MI325X 256GB, Qwen 3.5 27B achieves approximately 287.2 tokens per second decode speed with a time-to-first-token of 674ms using Q4_K_M quantization.

Can AMD Instinct MI325X 256GB run Qwen 3.5 27B for coding?

For coding workloads, Qwen 3.5 27B on AMD Instinct MI325X 256GB receives a S grade with 287.2 tok/s and 131K context.

What context window can Qwen 3.5 27B use on AMD Instinct MI325X 256GB?

On AMD Instinct MI325X 256GB, Qwen 3.5 27B can safely use up to 131K tokens of context. The model's official context limit is 131K, but available memory constrains the safe maximum.

See all results for AMD Instinct MI325X 256GB See all hardware for Qwen 3.5 27B

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<iframe src="https://willitrunai.com/embed/qwen-3.5-27b-on-instinct-mi325x-256gb" width="400" height="180" frameborder="0" style="border:none;border-radius:12px;overflow:hidden;" title="Will It Run AI — fit result"></iframe>

Preview:

Workload

Grade

Fit

Decode

TTFT

Context

Chat

Runs well

287.2 tok/s

368 ms

131K

Coding

Runs well

287.2 tok/s

674 ms

131K

Agentic Coding

Runs well

287.2 tok/s

980 ms

131K

Reasoning

Runs well

287.2 tok/s

797 ms

131K

RAG

Runs well

287.2 tok/s

1226 ms

131K

Quantization options

How Qwen 3.5 27B (27B params) fits at each quantization level on AMD Instinct MI325X 256GB (256.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	10.5 GB	Low	A79
Q3_K_S	3	13.2 GB	Low	A79
NVFP4	4	15.1 GB	Medium	A79
Q4_K_M	4	16.5 GB	Medium	A79
Q5_K_M	5	19.4 GB	High	A79
Q6_K	6	22.1 GB	High	A80
Q8_0	8	28.9 GB	Very High	A80
F16Best for your GPU	16	55.4 GB	Maximum	A82

Model

Params

Grade

Decode

Capabilities

Qwen 3.5 397B A17B

397B

39.2 tok/s

Devstral 2 123B Instruct

123B

63.5 tok/s

Qwen3-Coder 30B A3B Instruct

30.5B

662.3 tok/s

Frequently asked questions

Can AMD Instinct MI325X 256GB run Qwen 3.5 27B?

Yes, AMD Instinct MI325X 256GB can run Qwen 3.5 27B with a S grade (Runs well). Expected decode speed: 287.2 tok/s.

How much VRAM does Qwen 3.5 27B need?

Qwen 3.5 27B (27B parameters) requires approximately 46.1 GB of memory with Q4_K_M quantization.

What is the best quantization for Qwen 3.5 27B?

The recommended quantization for Qwen 3.5 27B is Q4_K_M, which balances quality and memory efficiency.

What speed will Qwen 3.5 27B run at on AMD Instinct MI325X 256GB?

On AMD Instinct MI325X 256GB, Qwen 3.5 27B achieves approximately 287.2 tokens per second decode speed with a time-to-first-token of 674ms using Q4_K_M quantization.

Can AMD Instinct MI325X 256GB run Qwen 3.5 27B for coding?

For coding workloads, Qwen 3.5 27B on AMD Instinct MI325X 256GB receives a S grade with 287.2 tok/s and 131K context.

What context window can Qwen 3.5 27B use on AMD Instinct MI325X 256GB?

On AMD Instinct MI325X 256GB, Qwen 3.5 27B can safely use up to 131K tokens of context. The model's official context limit is 131K, but available memory constrains the safe maximum.