Can Devstral 2 123B Instruct run on AMD Instinct MI210 64GB?

YES — With Q3_K_S

A80Great

Estimated from fit model

Devstral 2 123B Instruct needs ~72.9 GB VRAM. AMD Instinct MI210 64GB has 64.0 GB. With Q3_K_S quantization, expect ~11 tok/s.

Runtime: llama.cppCapacity: OffloadBandwidth: HighStack: StandardBottleneck: Host offload

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Devstral 2 123B Instruct at Q4_K_M needs 87.7 GB — too much for AMD Instinct MI210 64GB (64.0 GB). Runs at Q3_K_S (72.9 GB) with low quality. 2 quantization levels fit.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 87.7 GB, exceeds 64.0 GB available

87.7 GB required64.0 GB available

137% VRAM needed

23.7 GB over capacity — needs offload or smaller quantization

Fit status

Too heavy

Decode

6.2 tok/s

TTFT

31034 ms

Safe context

Memory

87.7 GB / 64.0 GB

Offload

30%

Memory breakdown

Weights75.0 GB

KV Cache5.4 GB

Runtime0.9 GB

Headroom6.4 GB

See how fast it feels

With memory offload — actual speed may be lower

See how fast it feelsDevstral 2 123B Instruct on AMD Instinct MI210 64GB
1st promptCold start — includes initialization
>Write a Python function to sort a list
Here's a Python function that sorts a list using quicksort:

def quicksort(arr):
    if len(arr) <= 1:
        return arr
    pivot = arr[len(arr) // 2]
    left   = [x for x in arr if x < pivot]
    middle = [x for x in arr if x == pivot]
    right  = [x for x in arr if x > pivot]
    return quicksort(left) + middle + quicksort(right)

# Example usage
numbers = [3, 6, 8, 10, 1, 2, 1]
print(quicksort(numbers))  # [1, 1, 2, 3, 6, 8, 10]

The algorithm picks a pivot, partitions the list into smaller, equal, and larger elements, then recursively sorts each partition and concatenates the results.
2nd promptWarm — model ready, no init overhead
>Now add type hints and a docstring
def quicksort(arr: list[int]) -> list[int]:
    """Sort a list using the quicksort algorithm.

    Args:
        arr: List of integers to sort.

    Returns:
        A new sorted list.
    """
    if len(arr) <= 1:
        return arr
    pivot = arr[len(arr) // 2]
    left   = [x for x in arr if x < pivot]
    middle = [x for x in arr if x == pivot]
    right  = [x for x in arr if x > pivot]
    return quicksort(left) + middle + quicksort(right)

Added type hints for the input and return type, plus a Google-style docstring.
Estimated: 6.2 tok/s decode · 31.0s TTFT (warm) · 16 tok/s prefill

What limits this setup

It fits through host-memory offload, and offload is the main reason performance drops.

CPU or host-memory offload is active

About 10% of the working set spills out of accelerator memory, which usually hurts latency and sustained decode throughput.

Very little memory headroom

You can run the model, but there is not much room left for longer context, bigger batches, extra apps, or future model updates.

Best improvement path

Remove offload with more accelerator memory

Prioritize a GPU or unified-memory tier that fits the whole model natively. Removing offload usually helps more than small compute gains.

Buy headroom, not only minimum fit

A slightly larger memory tier gives you safer context growth and makes the recommendation more future-proof.

Increase host RAM if you keep offloading

This setup may need roughly 7.4 GB of extra host RAM just for the offloaded portion, before OS and other tools.

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	F	Too heavy	6.7 tok/s	15855 ms	4K
Coding	F	Too heavy	6.2 tok/s	31034 ms	4K
Agentic Coding	F	Too heavy	5.5 tok/s	51158 ms	4K
Reasoning	F	Too heavy	6.2 tok/s	36677 ms	4K
RAG	F	Too heavy	5.5 tok/s	63947 ms	4K

Quantization options

How Devstral 2 123B Instruct (123B params) fits at each quantization level on AMD Instinct MI210 64GB (64.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_KBest for your GPU	2	48.0 GB	Low	S91
Q3_K_S	3	60.3 GB	Low	F0
NVFP4	4	68.9 GB	Medium	F0
Q4_K_M	4	75.0 GB	Medium	F0
Q5_K_M	5	88.6 GB	High	F0
Q6_K	6	100.9 GB	High	F0
Q8_0	8	131.6 GB	Very High	F0
F16	16	252.2 GB	Maximum	F0

Get started

Copy-paste commands to run Devstral 2 123B Instruct on your machine.

Run

lms load Devstral-2-123B-Instruct-2512 && lms server start

Opciones de mejora

Hardware que ejecuta bien Devstral 2 123B Instruct

AMD Instinct MI350X 288GBOpción económica

288 GB VRAM (+224)8000 GB/s (+6362)

Hace que el modelo quepa en el acelerador en lugar de seguir fuera de alcance.84.6 tok/s decodificación

Hace que el modelo quepa en el acelerador en lugar de seguir fuera de alcance.

Elimina el offload a memoria del sistema, que suele ser la mayor mejora individual en latencia y throughput.

~$8,000 MSRP

AMD Instinct MI300A 128GBMejor relación calidad-precio

128 GB VRAM (+64)5300 GB/s (+3662)

Hace que el modelo quepa en el acelerador en lugar de seguir fuera de alcance.53.8 tok/s decodificación

Hace que el modelo quepa en el acelerador en lugar de seguir fuera de alcance.

Elimina el offload a memoria del sistema, que suele ser la mayor mejora individual en latencia y throughput.

~$12,000 MSRP

AMD Instinct MI250X 128GBMejora AMD

128 GB VRAM (+64)3200 GB/s (+1562)

Hace que el modelo quepa en el acelerador en lugar de seguir fuera de alcance.36.2 tok/s decodificación

Hace que el modelo quepa en el acelerador en lugar de seguir fuera de alcance.

Elimina el offload a memoria del sistema, que suele ser la mayor mejora individual en latencia y throughput.

~$15,000 MSRP

Frequently asked questions

Can AMD Instinct MI210 64GB run Devstral 2 123B Instruct?

Yes, AMD Instinct MI210 64GB can run Devstral 2 123B Instruct at Q3_K_S quantization (Very compromised (needs ~7.4 GB host RAM)). The recommended Q4_K_M requires 87.7 GB which exceeds available memory, but at Q3_K_S it needs only 72.9 GB. Expected decode speed: 10.6 tok/s.

How much VRAM does Devstral 2 123B Instruct need?

Devstral 2 123B Instruct (123B parameters) requires approximately 87.7 GB at Q4_K_M quantization. On AMD Instinct MI210 64GB, it fits at Q3_K_S using 72.9 GB.

What is the best quantization for Devstral 2 123B Instruct?

The recommended quantization is Q4_K_M, but on AMD Instinct MI210 64GB the best fitting quantization is Q3_K_S, which uses 72.9 GB.

What speed will Devstral 2 123B Instruct run at on AMD Instinct MI210 64GB?

On AMD Instinct MI210 64GB, Devstral 2 123B Instruct achieves approximately 10.6 tokens per second decode speed with a time-to-first-token of 18187ms using Q3_K_S quantization.

Can AMD Instinct MI210 64GB run Devstral 2 123B Instruct for coding?

For coding workloads, Devstral 2 123B Instruct on AMD Instinct MI210 64GB receives a F grade with 6.2 tok/s and 4K context.

What context window can Devstral 2 123B Instruct use on AMD Instinct MI210 64GB?

On AMD Instinct MI210 64GB, Devstral 2 123B Instruct can safely use up to 4K tokens of context at Q3_K_S quantization. The model's official context limit is 256K, but available memory constrains the safe maximum.

What should I upgrade first if Devstral 2 123B Instruct feels slow on AMD Instinct MI210 64GB?

Remove offload with more accelerator memory. Prioritize a GPU or unified-memory tier that fits the whole model natively. Removing offload usually helps more than small compute gains.

See all results for AMD Instinct MI210 64GB See all hardware for Devstral 2 123B Instruct

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