Can Command R+ 104B run on AMD Instinct MI250X 128GB?

YES — Runs Great

A70Great

Estimated from fit model

Command R+ 104B needs ~80.6 GB VRAM. AMD Instinct MI250X 128GB has 128.0 GB. With Q4_K_M quantization, expect ~43 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 80.6 GB, 42.8 tok/s, Runs well

80.6 GB required128.0 GB available

63% VRAM used

Fit status

Runs well

Decode

42.8 tok/s

TTFT

4525 ms

Safe context

131K

Memory

80.6 GB / 128.0 GB

Memory breakdown

Weights63.4 GB

KV Cache3.4 GB

Runtime0.9 GB

Headroom12.8 GB

See how fast it feels

See how fast it feelsCommand R+ 104B on AMD Instinct MI250X 128GB
1st promptCold start — includes initialization
>Solve: If a train travels at 60 mph for 2.5 hours, how far does it go?
Let me work through this step by step.

Given information:
  - Speed = 60 mph (miles per hour)
  - Time  = 2.5 hours

Formula: Distance = Speed x Time

Calculation:
  Distance = 60 mph x 2.5 h
           = 150 miles

The train travels 150 miles.

Double-check: at 60 mph the train covers 60 miles each hour. In half an hour it covers 30 miles. So in 2.5 hours: 60 + 60 + 30 = 150 miles. Confirmed.
2nd promptWarm — model ready, no init overhead
>What if the train stops for 20 minutes halfway?
The stop doesn't change the total distance covered while moving, but it affects total trip time.

Breakdown:
  - First half: 1.25 hours at 60 mph = 75 miles
  - Stop: 20 minutes (no distance)
  - Second half: 1.25 hours at 60 mph = 75 miles

Total distance: 150 miles (same)
Total time: 2.5 h + 0.33 h = 2.83 hours
Average speed: 150 / 2.83 = 53 mph

The distance stays the same but average speed drops to 53 mph because of the stop.
Estimated: 42.8 tok/s decode · 4.5s TTFT (warm) · 107 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	B	Runs well	42.8 tok/s	2468 ms	131K
Coding	A	Runs well	42.8 tok/s	4525 ms	131K
Agentic Coding	A	Runs well	42.8 tok/s	6581 ms	131K
Reasoning	A	Runs well	42.8 tok/s	5347 ms	131K
RAG	A	Runs well	39.3 tok/s	8947 ms	131K

Quantization options

How Command R+ 104B (104B params) fits at each quantization level on AMD Instinct MI250X 128GB (128.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	40.6 GB	Low	B60
Q3_K_S	3	51.0 GB	Low	B62
NVFP4	4	58.2 GB	Medium	B63
Q4_K_M	4	63.4 GB	Medium	B64
Q5_K_M	5	74.9 GB	High	B65
Q6_KBest for your GPU	6	85.3 GB	High	B65
Q8_0	8	111.3 GB	Very High	F0
F16	16	213.2 GB	Maximum	F0

Get started

Copy-paste commands to run Command R+ 104B on your machine.

Run

ollama run command-r-plus

Your hardware

More models your AMD Instinct MI250X 128GB can run

Model	Params	Grade	Decode
Devstral 2 123B Instruct	123B	S	36.2 tok/s
Qwen 3.5 122B A10B	122B	S	100.3 tok/s
Mistral Small 4 119B	119B	S	108.8 tok/s
GPT-OSS 120B	117B	S	38 tok/s
Command A 111B	111B	S	40.2 tok/s

Frequently asked questions

Can AMD Instinct MI250X 128GB run Command R+ 104B?

Yes, AMD Instinct MI250X 128GB can run Command R+ 104B with a A grade (Runs well). Expected decode speed: 42.8 tok/s.

How much VRAM does Command R+ 104B need?

Command R+ 104B (104B parameters) requires approximately 80.6 GB of memory with Q4_K_M quantization.

What is the best quantization for Command R+ 104B?

The recommended quantization for Command R+ 104B is Q4_K_M, which balances quality and memory efficiency.

What speed will Command R+ 104B run at on AMD Instinct MI250X 128GB?

On AMD Instinct MI250X 128GB, Command R+ 104B achieves approximately 42.8 tokens per second decode speed with a time-to-first-token of 4525ms using Q4_K_M quantization.

Can AMD Instinct MI250X 128GB run Command R+ 104B for coding?

For coding workloads, Command R+ 104B on AMD Instinct MI250X 128GB receives a A grade with 42.8 tok/s and 131K context.

What context window can Command R+ 104B use on AMD Instinct MI250X 128GB?

On AMD Instinct MI250X 128GB, Command R+ 104B can safely use up to 131K tokens of context. The model's official context limit is 131K, but available memory constrains the safe maximum.

See all results for AMD Instinct MI250X 128GB See all hardware for Command R+ 104B

Embed this result▼

Paste this snippet into any page to show a live fit card.

<iframe src="https://willitrunai.com/embed/command-r-plus-104b-on-instinct-mi250x-128gb" width="400" height="180" frameborder="0" style="border:none;border-radius:12px;overflow:hidden;" title="Will It Run AI — fit result"></iframe>

Preview: