Qwen 2.5 VL 72B needs ~62.5 GB VRAM. AMD Instinct MI250 128GB has 128.0 GB. With Q4_K_M quantization, expect ~54 tok/s.
Operating mode
Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.
Current mode
Balanced
Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.
Select quantization to explore
Fit status
Runs well
Decode
53.9 tok/s
TTFT
3593 ms
Safe context
33K
Memory
62.5 GB / 128.0 GB
This setup is broadly balanced for this model.
No major red flags
This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.
| Workload | Grade | Fit | Decode | TTFT | Context |
|---|---|---|---|---|---|
| Chat | S | Runs well | 53.9 tok/s | 1960 ms | 33K |
| Coding | S | Runs well | 53.9 tok/s | 3593 ms | 33K |
| Agentic Coding | S | Runs well | 53.9 tok/s | 5226 ms | 33K |
| Reasoning | S | Runs well | 53.9 tok/s | 4246 ms | 33K |
| RAG | S | Runs well | 53.9 tok/s | 6533 ms | 33K |
Inference speed
Estimated decode speed (tokens/sec) for Qwen 2.5 VL 72B at Q4_K_M across popular GPUs and Apple Silicon, including multi-GPU rigs, using the fastest local runtime per device. Fastest is 2× RX 7900 XTX 24GB at ~17 tok/s. Speed is memory-bandwidth bound, so cards that fit the whole model in VRAM run far faster than ones that offload to system RAM.
| GPU / Mac | Memory | Quant | Speed (tok/s) | Fits? |
|---|---|---|---|---|
2× RX 7900 XTX 24GB | 48 GB | Q4_K_M | 16.7 | Heavy offload |
MacBook Pro M4 Max 128GB | 128 GB | Q4_K_M | 14.9 | Fits |
Mac Studio M3 Ultra 256GB | 256 GB | Q4_K_M | 13.8 | Fits |
Mac Studio M2 Ultra 128GB | 128 GB | Q4_K_M | 11.5 | Fits |
MacBook Pro M4 Max 64GB | 64 GB | Q4_K_M | 11.0 | Too big |
Mac Studio M1 Ultra 128GB | 128 GB | Q4_K_M | 10.9 | Fits |
 2× RTX 4090 24GB | 48 GB | Q4_K_M | 8.8 | Heavy offload |
| 2× RTX 3090 24GB | 48 GB | Q4_K_M | 8.1 | Heavy offload |
| 4× RTX 3060 12GB | 48 GB | Q4_K_M | 7.1 | Heavy offload |
| RTX 5090 32GB | 32 GB | Q4_K_M | 5.3 | Too big |
MacBook Pro M4 Pro 48GB | 48 GB | Q4_K_M | 5.1 | Too big |
MacBook Pro M3 Max 64GB | 64 GB | Q4_K_M | 4.4 | Too big |
MacBook Pro M1 Max 64GB | 64 GB | Q4_K_M | 4.0 | Too big |
RX 7900 XTX 24GB | 24 GB | Q4_K_M | 2.6 | Too big |
| RTX 4090 24GB | 24 GB | Q4_K_M | 2.0 | Too big |
| RTX 4080 Super 16GB | 16 GB | Q4_K_M | 2.0 | Too big |
| RTX 3090 24GB | 24 GB | Q4_K_M | 2.0 | Too big |
| RTX 4070 12GB | 12 GB | Q4_K_M | 2.0 | Too big |
| RTX 3060 12GB | 12 GB | Q4_K_M | 2.0 | Too big |
| RTX 4060 8GB | 8 GB | Q4_K_M | 2.0 | Too big |
Estimates for single-stream decoding at Q4_K_M; real tokens/sec varies with prompt length, context, batch size, and runtime build. Prompt processing (prefill) is faster than the decode figures shown here.
How Qwen 2.5 VL 72B (72B params) fits at each quantization level on AMD Instinct MI250 128GB (128.0 GB usable).
| Quant | Bits | VRAM | Quality | Fit |
|---|---|---|---|---|
Q2_K | 2 | 28.1 GB | Low | A81 |
Q3_K_S | 3 | 35.3 GB | Low | A82 |
NVFP4 | 4 | 40.3 GB | Medium | A83 |
Q4_K_M | 4 | 43.9 GB | Medium | A84 |
Q5_K_M | 5 | 51.8 GB | High | A85 |
Q6_K | 6 | 59.0 GB | High | S86 |
Q8_0Best for your GPU | 8 | 77.0 GB | Very High | S88 |
F16 | 16 | 147.6 GB | Maximum | F0 |
Copy-paste commands to run Qwen 2.5 VL 72B on your machine.
Run
lms load Qwen2.5-VL-72B-Instruct && lms server startYour hardware
| Model | Params | Grade | Decode | Capabilities |
|---|---|---|---|---|
 Devstral 2 123B Instruct | 123B | S | 31.5 tok/s | |
 Qwen 3.5 122B A10B | 122B | S | 87.5 tok/s | |
| Mistral Small 4 119B | 119B | S | 94.8 tok/s | |
 GPT-OSS 120B | 117B | S | 33.2 tok/s | |
 Command A 111B | 111B | S | 35.1 tok/s |
Yes, AMD Instinct MI250 128GB can run Qwen 2.5 VL 72B with a S grade (Runs well). Expected decode speed: 53.9 tok/s.
Qwen 2.5 VL 72B (72B parameters) requires approximately 62.5 GB of memory with Q4_K_M quantization.
The recommended quantization for Qwen 2.5 VL 72B is Q4_K_M, which balances quality and memory efficiency.
On AMD Instinct MI250 128GB, Qwen 2.5 VL 72B achieves approximately 53.9 tokens per second decode speed with a time-to-first-token of 3593ms using Q4_K_M quantization.
For coding workloads, Qwen 2.5 VL 72B on AMD Instinct MI250 128GB receives a S grade with 53.9 tok/s and 33K context.
On AMD Instinct MI250 128GB, Qwen 2.5 VL 72B can safely use up to 33K tokens of context. The model's official context limit is 33K, but available memory constrains the safe maximum.
Paste this snippet into any page to show a live fit card.
<iframe src="https://willitrunai.com/embed/qwen-2.5-vl-72b-on-instinct-mi250-128gb" width="400" height="180" frameborder="0" style="border:none;border-radius:12px;overflow:hidden;" title="Will It Run AI — fit result"></iframe>
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