Can Phi-4 Mini Reasoning 4B run on AMD Instinct MI350X 288GB?

YES — Runs Great

A80Great

Estimated from fit model

Phi-4 Mini Reasoning 4B needs ~33.5 GB VRAM. AMD Instinct MI350X 288GB has 288.0 GB. With Q4_K_M quantization, expect ~53 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 33.5 GB, 53.2 tok/s, Runs well

33.5 GB required288.0 GB available

12% VRAM used

Fit status

Runs well

Decode

53.2 tok/s

TTFT

3639 ms

Safe context

131K

Memory

33.5 GB / 288.0 GB

Memory breakdown

Weights2.3 GB

KV Cache1.5 GB

Runtime0.9 GB

Headroom28.8 GB

See how fast it feels

See how fast it feelsPhi-4 Mini Reasoning 4B on AMD Instinct MI350X 288GB
1st promptCold start — includes initialization
>Solve: If a train travels at 60 mph for 2.5 hours, how far does it go?
Let me work through this step by step.

Given information:
  - Speed = 60 mph (miles per hour)
  - Time  = 2.5 hours

Formula: Distance = Speed x Time

Calculation:
  Distance = 60 mph x 2.5 h
           = 150 miles

The train travels 150 miles.

Double-check: at 60 mph the train covers 60 miles each hour. In half an hour it covers 30 miles. So in 2.5 hours: 60 + 60 + 30 = 150 miles. Confirmed.
2nd promptWarm — model ready, no init overhead
>What if the train stops for 20 minutes halfway?
The stop doesn't change the total distance covered while moving, but it affects total trip time.

Breakdown:
  - First half: 1.25 hours at 60 mph = 75 miles
  - Stop: 20 minutes (no distance)
  - Second half: 1.25 hours at 60 mph = 75 miles

Total distance: 150 miles (same)
Total time: 2.5 h + 0.33 h = 2.83 hours
Average speed: 150 / 2.83 = 53 mph

The distance stays the same but average speed drops to 53 mph because of the stop.
Estimated: 53.2 tok/s decode · 3.6s TTFT (warm) · 133 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	A	Runs well	53.2 tok/s	1985 ms	131K
Coding	A	Runs well	53.2 tok/s	3639 ms	131K
Agentic Coding	A	Runs well	53.2 tok/s	5293 ms	131K
Reasoning	A	Runs well	53.2 tok/s	4301 ms	131K
RAG	A	Runs well	53.2 tok/s	6617 ms	131K

Quantization options

How Phi-4 Mini Reasoning 4B (3.799999952316284B params) fits at each quantization level on AMD Instinct MI350X 288GB (288.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	1.5 GB	Low	A73
Q3_K_S	3	1.9 GB	Low	A73
NVFP4	4

Get started

Copy-paste commands to run Phi-4 Mini Reasoning 4B on your machine.

Run

ollama run phi4-mini

Your hardware

More models your AMD Instinct MI350X 288GB can run

Model	Params	Grade	Decode	Capabilities
Qwen 3.5 397B A17B	397B	S	78.9 tok/s
Devstral 2 123B Instruct	123B	S

Frequently asked questions

Can AMD Instinct MI350X 288GB run Phi-4 Mini Reasoning 4B?

Yes, AMD Instinct MI350X 288GB can run Phi-4 Mini Reasoning 4B with a A grade (Runs well). Expected decode speed: 53.2 tok/s.

How much VRAM does Phi-4 Mini Reasoning 4B need?

Phi-4 Mini Reasoning 4B (3.799999952316284B parameters) requires approximately 33.5 GB of memory with Q4_K_M quantization.

What is the best quantization for Phi-4 Mini Reasoning 4B?

The recommended quantization for Phi-4 Mini Reasoning 4B is Q4_K_M, which balances quality and memory efficiency.

What speed will Phi-4 Mini Reasoning 4B run at on AMD Instinct MI350X 288GB?

On AMD Instinct MI350X 288GB, Phi-4 Mini Reasoning 4B achieves approximately 53.2 tokens per second decode speed with a time-to-first-token of 3639ms using Q4_K_M quantization.

Can AMD Instinct MI350X 288GB run Phi-4 Mini Reasoning 4B for coding?

For coding workloads, Phi-4 Mini Reasoning 4B on AMD Instinct MI350X 288GB receives a A grade with 53.2 tok/s and 131K context.

What context window can Phi-4 Mini Reasoning 4B use on AMD Instinct MI350X 288GB?

On AMD Instinct MI350X 288GB, Phi-4 Mini Reasoning 4B can safely use up to 131K tokens of context. The model's official context limit is 131K, but available memory constrains the safe maximum.

See all results for AMD Instinct MI350X 288GB See all hardware for Phi-4 Mini Reasoning 4B

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