Can Ministral 3 14B run on AMD Instinct MI250 128GB?

YES — Runs Great

A81Great

Estimated from fit model

Ministral 3 14B needs ~26.2 GB VRAM. AMD Instinct MI250 128GB has 128.0 GB. With Q4_K_M quantization, expect ~196 tok/s.

Runtime: vLLMCapacity: RoomyBandwidth: HighStack: OptimizedBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 26.2 GB, 196.0 tok/s, Runs well

26.2 GB required128.0 GB available

20% VRAM used

Fit status

Runs well

Decode

196.0 tok/s

TTFT

988 ms

Safe context

262K

Memory

26.2 GB / 128.0 GB

Memory breakdown

Weights8.5 GB

KV Cache2.4 GB

Runtime2.4 GB

Headroom12.8 GB

See how fast it feels

See how fast it feelsMinistral 3 14B on AMD Instinct MI250 128GB
1st promptCold start — includes initialization
>What is local AI inference?
Local AI inference means running an AI language model directly on your own hardware — your laptop, desktop, or server — instead of sending requests to a remote cloud API.

When you run inference locally the model weights are loaded into your GPU or unified memory. Each token you generate requires reading those weights from memory, so memory bandwidth is the main bottleneck for decode speed.

Key benefits of running locally:
  - Full privacy: your prompts never leave your machine
  - No per-token cost or rate limits
  - Works offline once the model is downloaded
  - Latency depends only on your hardware
2nd promptWarm — model ready, no init overhead
>How much VRAM do I need?
It depends on the model size and quantization level. A rough rule of thumb:

  Model size     Q4 (4-bit)    Q8 (8-bit)    FP16
  7B params      ~4.3 GB       ~7.5 GB       ~14 GB
  13B params     ~7.9 GB       ~13.9 GB      ~26 GB
  70B params     ~42.7 GB      ~74.9 GB      ~140 GB

Most people use 4-bit quantization (Q4_K_M) which gives 90-95% of full quality at a fraction of the memory. A 24 GB GPU can comfortably run most 7B-13B models.
Estimated: 196.0 tok/s decode · 988ms TTFT (warm) · 490 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	A	Runs well	196.0 tok/s	539 ms	262K
Coding	A	Runs well	196.0 tok/s	988 ms	262K
Agentic Coding	A	Runs well	196.0 tok/s	1437 ms	262K
Reasoning	A	Runs well	196.0 tok/s	1167 ms	262K
RAG	A	Runs well	196.0 tok/s	1796 ms	262K

Quantization options

How Ministral 3 14B (14B params) fits at each quantization level on AMD Instinct MI250 128GB (128.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	5.5 GB	Low	A73
Q3_K_S	3	6.9 GB	Low	A73
NVFP4	4

Get started

Copy-paste commands to run Ministral 3 14B on your machine.

Run

docker run --rm -it ghcr.io/ggerganov/llama.cpp:full \
  --hf-repo "mistralai/Ministral-3-14B-Instruct-2512" \
  --hf-file "Ministral-3-14B-Instruct-2512-Q4_K_M.gguf" \
  -c 4096 -ngl 99

Your hardware

More models your AMD Instinct MI250 128GB can run

Model	Params	Grade	Decode	Capabilities
Devstral 2 123B Instruct	123B	S	25.2 tok/s
Qwen3-Coder 30B A3B Instruct	30.5B	S

Frequently asked questions

Can AMD Instinct MI250 128GB run Ministral 3 14B?

Yes, AMD Instinct MI250 128GB can run Ministral 3 14B with a A grade (Runs well). Expected decode speed: 196.0 tok/s.

How much VRAM does Ministral 3 14B need?

Ministral 3 14B (14B parameters) requires approximately 26.2 GB of memory with Q4_K_M quantization.

What is the best quantization for Ministral 3 14B?

The recommended quantization for Ministral 3 14B is Q4_K_M, which balances quality and memory efficiency.

What speed will Ministral 3 14B run at on AMD Instinct MI250 128GB?

On AMD Instinct MI250 128GB, Ministral 3 14B achieves approximately 196.0 tokens per second decode speed with a time-to-first-token of 988ms using Q4_K_M quantization.

Can AMD Instinct MI250 128GB run Ministral 3 14B for coding?

For coding workloads, Ministral 3 14B on AMD Instinct MI250 128GB receives a A grade with 196.0 tok/s and 262K context.

What context window can Ministral 3 14B use on AMD Instinct MI250 128GB?

On AMD Instinct MI250 128GB, Ministral 3 14B can safely use up to 262K tokens of context. The model's official context limit is 262K, but available memory constrains the safe maximum.

See all results for AMD Instinct MI250 128GB See all hardware for Ministral 3 14B

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