Can MiniCPM-V 2.6 8B run on AMD Instinct MI250X 128GB?

YES — Runs Great

A76Great

Estimated from fit model

MiniCPM-V 2.6 8B needs ~20.5 GB VRAM. AMD Instinct MI250X 128GB has 128.0 GB. With Q4_K_M quantization, expect ~112 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 20.5 GB, 112.0 tok/s, Runs well

20.5 GB required128.0 GB available

16% VRAM used

Fit status

Runs well

Decode

112.0 tok/s

TTFT

1729 ms

Safe context

Memory

20.5 GB / 128.0 GB

Memory breakdown

Weights4.9 GB

KV Cache2.0 GB

Runtime0.9 GB

Headroom12.8 GB

See how fast it feels

See how fast it feelsMiniCPM-V 2.6 8B on AMD Instinct MI250X 128GB
1st promptCold start — includes initialization
>What is local AI inference?
Local AI inference means running an AI language model directly on your own hardware — your laptop, desktop, or server — instead of sending requests to a remote cloud API.

When you run inference locally the model weights are loaded into your GPU or unified memory. Each token you generate requires reading those weights from memory, so memory bandwidth is the main bottleneck for decode speed.

Key benefits of running locally:
  - Full privacy: your prompts never leave your machine
  - No per-token cost or rate limits
  - Works offline once the model is downloaded
  - Latency depends only on your hardware
2nd promptWarm — model ready, no init overhead
>How much VRAM do I need?
It depends on the model size and quantization level. A rough rule of thumb:

  Model size     Q4 (4-bit)    Q8 (8-bit)    FP16
  7B params      ~4.3 GB       ~7.5 GB       ~14 GB
  13B params     ~7.9 GB       ~13.9 GB      ~26 GB
  70B params     ~42.7 GB      ~74.9 GB      ~140 GB

Most people use 4-bit quantization (Q4_K_M) which gives 90-95% of full quality at a fraction of the memory. A 24 GB GPU can comfortably run most 7B-13B models.
Estimated: 112.0 tok/s decode · 1.7s TTFT (warm) · 280 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	A	Runs well	112.0 tok/s	943 ms	2K
Coding	A	Runs well	112.0 tok/s	1729 ms	2K
Agentic Coding	A	Runs well	112.0 tok/s	2514 ms	2K
Reasoning	A	Runs well	112.0 tok/s	2043 ms	2K
RAG	A	Runs well	112.0 tok/s	3143 ms	2K

Quantization options

How MiniCPM-V 2.6 8B (8B params) fits at each quantization level on AMD Instinct MI250X 128GB (128.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	3.1 GB	Low	B69
Q3_K_S	3	3.9 GB	Low	B69
NVFP4	4

Get started

Copy-paste commands to run MiniCPM-V 2.6 8B on your machine.

Run

docker run --rm -it ghcr.io/ggerganov/llama.cpp:full \
  --hf-repo "openbmb/MiniCPM-V-2_6" \
  --hf-file "MiniCPM-V-2_6-Q4_K_M.gguf" \
  -c 4096 -ngl 99

Your hardware

More models your AMD Instinct MI250X 128GB can run

Model	Params	Grade	Decode	Capabilities
Devstral 2 123B Instruct	123B	S	36.2 tok/s
Qwen3-Coder 30B A3B Instruct	30.5B	S

Frequently asked questions

Can AMD Instinct MI250X 128GB run MiniCPM-V 2.6 8B?

Yes, AMD Instinct MI250X 128GB can run MiniCPM-V 2.6 8B with a A grade (Runs well). Expected decode speed: 112.0 tok/s.

How much VRAM does MiniCPM-V 2.6 8B need?

MiniCPM-V 2.6 8B (8B parameters) requires approximately 20.5 GB of memory with Q4_K_M quantization.

What is the best quantization for MiniCPM-V 2.6 8B?

The recommended quantization for MiniCPM-V 2.6 8B is Q4_K_M, which balances quality and memory efficiency.

What speed will MiniCPM-V 2.6 8B run at on AMD Instinct MI250X 128GB?

On AMD Instinct MI250X 128GB, MiniCPM-V 2.6 8B achieves approximately 112.0 tokens per second decode speed with a time-to-first-token of 1729ms using Q4_K_M quantization.

Can AMD Instinct MI250X 128GB run MiniCPM-V 2.6 8B for coding?

For coding workloads, MiniCPM-V 2.6 8B on AMD Instinct MI250X 128GB receives a A grade with 112.0 tok/s and 2K context.

What context window can MiniCPM-V 2.6 8B use on AMD Instinct MI250X 128GB?

On AMD Instinct MI250X 128GB, MiniCPM-V 2.6 8B can safely use up to 2K tokens of context. The model's official context limit is 2K, but available memory constrains the safe maximum.

See all results for AMD Instinct MI250X 128GB See all hardware for MiniCPM-V 2.6 8B

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