Can Gemma 4 31B run on AMD Instinct MI250 128GB?

YES — Runs Great

S86Excellent

Estimated from fit model

Gemma 4 31B needs ~47.1 GB VRAM. AMD Instinct MI250 128GB has 128.0 GB. With Q4_K_M quantization, expect ~76 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 47.1 GB, 75.8 tok/s, Runs well

47.1 GB required128.0 GB available

37% VRAM used

Fit status

Runs well

Decode

75.8 tok/s

TTFT

2553 ms

Safe context

104K

Memory

47.1 GB / 128.0 GB

Memory breakdown

Weights18.7 GB

KV Cache14.6 GB

Runtime0.9 GB

Headroom12.8 GB

See how fast it feels

See how fast it feelsGemma 4 31B on AMD Instinct MI250 128GB
1st promptCold start — includes initialization
>Write a Python function to sort a list
Here's a Python function that sorts a list using quicksort:

def quicksort(arr):
    if len(arr) <= 1:
        return arr
    pivot = arr[len(arr) // 2]
    left   = [x for x in arr if x < pivot]
    middle = [x for x in arr if x == pivot]
    right  = [x for x in arr if x > pivot]
    return quicksort(left) + middle + quicksort(right)

# Example usage
numbers = [3, 6, 8, 10, 1, 2, 1]
print(quicksort(numbers))  # [1, 1, 2, 3, 6, 8, 10]

The algorithm picks a pivot, partitions the list into smaller, equal, and larger elements, then recursively sorts each partition and concatenates the results.
2nd promptWarm — model ready, no init overhead
>Now add type hints and a docstring
def quicksort(arr: list[int]) -> list[int]:
    """Sort a list using the quicksort algorithm.

    Args:
        arr: List of integers to sort.

    Returns:
        A new sorted list.
    """
    if len(arr) <= 1:
        return arr
    pivot = arr[len(arr) // 2]
    left   = [x for x in arr if x < pivot]
    middle = [x for x in arr if x == pivot]
    right  = [x for x in arr if x > pivot]
    return quicksort(left) + middle + quicksort(right)

Added type hints for the input and return type, plus a Google-style docstring.
Estimated: 75.8 tok/s decode · 2.6s TTFT (warm) · 190 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	A	Runs well	75.8 tok/s	1393 ms	104K
Coding	S	Runs well	75.8 tok/s	2553 ms	104K
Agentic Coding	S	Runs well	75.8 tok/s	3714 ms	104K
Reasoning	S	Runs well	75.8 tok/s	3018 ms	104K
RAG	S	Runs well	75.8 tok/s	4643 ms	104K

Quantization options

How Gemma 4 31B (30.700000762939453B params) fits at each quantization level on AMD Instinct MI250 128GB (128.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	12.0 GB	Low	A75
Q3_K_S	3	15.0 GB	Low	A76
NVFP4	4	17.2 GB	Medium	A76
Q4_K_M	4	18.7 GB	Medium	A76
Q5_K_M	5	22.1 GB	High	A76
Q6_K	6	25.2 GB	High	A76
Q8_0	8	32.8 GB	Very High	A78
F16Best for your GPU	16	62.9 GB	Maximum	A83

Get started

Copy-paste commands to run Gemma 4 31B on your machine.

Run

ollama run gemma4:31b

Your hardware

More models your AMD Instinct MI250 128GB can run

Model	Params	Grade	Decode
Devstral 2 123B Instruct	123B	S	31.5 tok/s
Qwen 3.5 122B A10B	122B	S	87.5 tok/s
Qwen 3.6 35B A3B	35B	S	276.5 tok/s
Qwen 3.5 35B A3B	35B	S	300.7 tok/s
Qwen 3 32B	32B	S	121.2 tok/s

Frequently asked questions

Can AMD Instinct MI250 128GB run Gemma 4 31B?

Yes, AMD Instinct MI250 128GB can run Gemma 4 31B with a S grade (Runs well). Expected decode speed: 75.8 tok/s.

How much VRAM does Gemma 4 31B need?

Gemma 4 31B (30.700000762939453B parameters) requires approximately 47.1 GB of memory with Q4_K_M quantization.

What is the best quantization for Gemma 4 31B?

The recommended quantization for Gemma 4 31B is Q4_K_M, which balances quality and memory efficiency.

What speed will Gemma 4 31B run at on AMD Instinct MI250 128GB?

On AMD Instinct MI250 128GB, Gemma 4 31B achieves approximately 75.8 tokens per second decode speed with a time-to-first-token of 2553ms using Q4_K_M quantization.

Can AMD Instinct MI250 128GB run Gemma 4 31B for coding?

For coding workloads, Gemma 4 31B on AMD Instinct MI250 128GB receives a S grade with 75.8 tok/s and 104K context.

What context window can Gemma 4 31B use on AMD Instinct MI250 128GB?

On AMD Instinct MI250 128GB, Gemma 4 31B can safely use up to 104K tokens of context. The model's official context limit is 256K, but available memory constrains the safe maximum.

See all results for AMD Instinct MI250 128GB See all hardware for Gemma 4 31B

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<iframe src="https://willitrunai.com/embed/gemma-4-31b-on-instinct-mi250-128gb" width="400" height="180" frameborder="0" style="border:none;border-radius:12px;overflow:hidden;" title="Will It Run AI — fit result"></iframe>

Preview:

Workload

Grade

Fit

Decode

TTFT

Context

Chat

Runs well

75.8 tok/s

1393 ms

104K

Coding

Runs well

75.8 tok/s

2553 ms

104K

Agentic Coding

Runs well

75.8 tok/s

3714 ms

104K

Reasoning

Runs well

75.8 tok/s

3018 ms

104K

RAG

Runs well

75.8 tok/s

4643 ms

104K

Quantization options

How Gemma 4 31B (30.700000762939453B params) fits at each quantization level on AMD Instinct MI250 128GB (128.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	12.0 GB	Low	A75
Q3_K_S	3	15.0 GB	Low	A76
NVFP4	4	17.2 GB	Medium	A76
Q4_K_M	4	18.7 GB	Medium	A76
Q5_K_M	5	22.1 GB	High	A76
Q6_K	6	25.2 GB	High	A76
Q8_0	8	32.8 GB	Very High	A78
F16Best for your GPU	16	62.9 GB	Maximum	A83

Model

Params

Grade

Decode

Capabilities

Devstral 2 123B Instruct

123B

31.5 tok/s

Qwen 3.5 122B A10B

122B

87.5 tok/s

Qwen 3.6 35B A3B

35B

276.5 tok/s

Qwen 3.5 35B A3B

35B

300.7 tok/s

Qwen 3 32B

32B

121.2 tok/s

Frequently asked questions

Can AMD Instinct MI250 128GB run Gemma 4 31B?

Yes, AMD Instinct MI250 128GB can run Gemma 4 31B with a S grade (Runs well). Expected decode speed: 75.8 tok/s.

How much VRAM does Gemma 4 31B need?

Gemma 4 31B (30.700000762939453B parameters) requires approximately 47.1 GB of memory with Q4_K_M quantization.

What is the best quantization for Gemma 4 31B?

The recommended quantization for Gemma 4 31B is Q4_K_M, which balances quality and memory efficiency.

What speed will Gemma 4 31B run at on AMD Instinct MI250 128GB?

On AMD Instinct MI250 128GB, Gemma 4 31B achieves approximately 75.8 tokens per second decode speed with a time-to-first-token of 2553ms using Q4_K_M quantization.

Can AMD Instinct MI250 128GB run Gemma 4 31B for coding?

For coding workloads, Gemma 4 31B on AMD Instinct MI250 128GB receives a S grade with 75.8 tok/s and 104K context.

What context window can Gemma 4 31B use on AMD Instinct MI250 128GB?

On AMD Instinct MI250 128GB, Gemma 4 31B can safely use up to 104K tokens of context. The model's official context limit is 256K, but available memory constrains the safe maximum.