Can Devstral Small 2 24B Instruct run on AMD Instinct MI250X 128GB?

YES — Runs Great

S88Excellent

Estimated from fit model

Devstral Small 2 24B Instruct needs ~30.8 GB VRAM. AMD Instinct MI250X 128GB has 128.0 GB. With Q4_K_M quantization, expect ~171 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 30.8 GB, 183.3 tok/s, Runs well

30.8 GB required128.0 GB available

24% VRAM used

Fit status

Runs well

Decode

183.3 tok/s

TTFT

1056 ms

Safe context

256K

Memory

30.8 GB / 128.0 GB

Memory breakdown

Weights14.6 GB

KV Cache2.4 GB

Runtime0.9 GB

Headroom12.8 GB

See how fast it feels

See how fast it feelsDevstral Small 2 24B Instruct on AMD Instinct MI250X 128GB
1st promptCold start — includes initialization
>Write a Python function to sort a list
Here's a Python function that sorts a list using quicksort:

def quicksort(arr):
    if len(arr) <= 1:
        return arr
    pivot = arr[len(arr) // 2]
    left   = [x for x in arr if x < pivot]
    middle = [x for x in arr if x == pivot]
    right  = [x for x in arr if x > pivot]
    return quicksort(left) + middle + quicksort(right)

# Example usage
numbers = [3, 6, 8, 10, 1, 2, 1]
print(quicksort(numbers))  # [1, 1, 2, 3, 6, 8, 10]

The algorithm picks a pivot, partitions the list into smaller, equal, and larger elements, then recursively sorts each partition and concatenates the results.
2nd promptWarm — model ready, no init overhead
>Now add type hints and a docstring
def quicksort(arr: list[int]) -> list[int]:
    """Sort a list using the quicksort algorithm.

    Args:
        arr: List of integers to sort.

    Returns:
        A new sorted list.
    """
    if len(arr) <= 1:
        return arr
    pivot = arr[len(arr) // 2]
    left   = [x for x in arr if x < pivot]
    middle = [x for x in arr if x == pivot]
    right  = [x for x in arr if x > pivot]
    return quicksort(left) + middle + quicksort(right)

Added type hints for the input and return type, plus a Google-style docstring.
Estimated: 183.3 tok/s decode · 1.1s TTFT (warm) · 458 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	S	Runs well	183.3 tok/s	576 ms	256K
Coding	S	Runs well	170.5 tok/s	1136 ms	256K
Agentic Coding	S	Runs well	183.3 tok/s	1536 ms	256K
Reasoning	S	Runs well	183.3 tok/s	1248 ms	256K
RAG	S	Runs well	183.3 tok/s	1921 ms	256K

Quantization options

How Devstral Small 2 24B Instruct (24B params) fits at each quantization level on AMD Instinct MI250X 128GB (128.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	9.4 GB	Low	A80
Q3_K_S	3	11.8 GB	Low	A80
NVFP4	4

Get started

Copy-paste commands to run Devstral Small 2 24B Instruct on your machine.

Run

ollama run devstral-small-2

Your hardware

More models your AMD Instinct MI250X 128GB can run

Model	Params	Grade	Decode	Capabilities
Devstral 2 123B Instruct	123B	S	36.2 tok/s
Qwen3-Coder 30B A3B Instruct	30.5B	S

Frequently asked questions

Can AMD Instinct MI250X 128GB run Devstral Small 2 24B Instruct?

Yes, AMD Instinct MI250X 128GB can run Devstral Small 2 24B Instruct with a S grade (Runs well). Expected decode speed: 170.5 tok/s.

How much VRAM does Devstral Small 2 24B Instruct need?

Devstral Small 2 24B Instruct (24B parameters) requires approximately 30.8 GB of memory with Q4_K_M quantization.

What is the best quantization for Devstral Small 2 24B Instruct?

The recommended quantization for Devstral Small 2 24B Instruct is Q4_K_M, which balances quality and memory efficiency.

What speed will Devstral Small 2 24B Instruct run at on AMD Instinct MI250X 128GB?

On AMD Instinct MI250X 128GB, Devstral Small 2 24B Instruct achieves approximately 170.5 tokens per second decode speed with a time-to-first-token of 1136ms using Q4_K_M quantization.

Can AMD Instinct MI250X 128GB run Devstral Small 2 24B Instruct for coding?

For coding workloads, Devstral Small 2 24B Instruct on AMD Instinct MI250X 128GB receives a S grade with 170.5 tok/s and 256K context.

What context window can Devstral Small 2 24B Instruct use on AMD Instinct MI250X 128GB?

On AMD Instinct MI250X 128GB, Devstral Small 2 24B Instruct can safely use up to 256K tokens of context. The model's official context limit is 256K, but available memory constrains the safe maximum.

See all results for AMD Instinct MI250X 128GB See all hardware for Devstral Small 2 24B Instruct

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