Can CogVLM2 19B run on AMD Instinct MI350X 288GB?

YES — Runs Great

A78Great

Estimated from fit model

CogVLM2 19B needs ~43.7 GB VRAM. AMD Instinct MI350X 288GB has 288.0 GB. With Q4_K_M quantization, expect ~266 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 43.7 GB, 266.0 tok/s, Runs well

43.7 GB required288.0 GB available

15% VRAM used

Fit status

Runs well

Decode

266.0 tok/s

TTFT

728 ms

Safe context

Memory

43.7 GB / 288.0 GB

Memory breakdown

Weights11.6 GB

KV Cache2.4 GB

Runtime0.9 GB

Headroom28.8 GB

See how fast it feels

See how fast it feelsCogVLM2 19B on AMD Instinct MI350X 288GB
1st promptCold start — includes initialization
>What is local AI inference?
Local AI inference means running an AI language model directly on your own hardware — your laptop, desktop, or server — instead of sending requests to a remote cloud API.

When you run inference locally the model weights are loaded into your GPU or unified memory. Each token you generate requires reading those weights from memory, so memory bandwidth is the main bottleneck for decode speed.

Key benefits of running locally:
  - Full privacy: your prompts never leave your machine
  - No per-token cost or rate limits
  - Works offline once the model is downloaded
  - Latency depends only on your hardware
2nd promptWarm — model ready, no init overhead
>How much VRAM do I need?
It depends on the model size and quantization level. A rough rule of thumb:

  Model size     Q4 (4-bit)    Q8 (8-bit)    FP16
  7B params      ~4.3 GB       ~7.5 GB       ~14 GB
  13B params     ~7.9 GB       ~13.9 GB      ~26 GB
  70B params     ~42.7 GB      ~74.9 GB      ~140 GB

Most people use 4-bit quantization (Q4_K_M) which gives 90-95% of full quality at a fraction of the memory. A 24 GB GPU can comfortably run most 7B-13B models.
Estimated: 266.0 tok/s decode · 728ms TTFT (warm) · 665 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	A	Runs well	266.0 tok/s	397 ms	8K
Coding	A	Runs well	266.0 tok/s	728 ms	8K
Agentic Coding	A	Runs well	266.0 tok/s	1059 ms	8K
Reasoning	A	Runs well	266.0 tok/s	860 ms	8K
RAG	A	Runs well	266.0 tok/s	1323 ms	8K

Quantization options

How CogVLM2 19B (19B params) fits at each quantization level on AMD Instinct MI350X 288GB (288.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	7.4 GB	Low	B69
Q3_K_S	3	9.3 GB	Low	B69
NVFP4	4	10.6 GB	Medium	B69
Q4_K_M	4	11.6 GB	Medium	B69
Q5_K_M	5	13.7 GB	High	B69
Q6_K	6	15.6 GB	High	B70
Q8_0	8	20.3 GB	Very High	B70
F16Best for your GPU	16	38.9 GB	Maximum	A71

Get started

Copy-paste commands to run CogVLM2 19B on your machine.

Run

docker run --rm -it ghcr.io/ggerganov/llama.cpp:full \
  --hf-repo "THUDM/cogvlm2-llama3-chat-19B" \
  --hf-file "cogvlm2-llama3-chat-19B-Q4_K_M.gguf" \
  -c 4096 -ngl 99

Your hardware

More models your AMD Instinct MI350X 288GB can run

Model	Params	Grade	Decode
Qwen 3.5 397B A17B	397B	S	78.9 tok/s
Devstral 2 123B Instruct	123B	S	84.6 tok/s
Qwen3-Coder 30B A3B Instruct	30.5B	S	883.1 tok/s
Qwen 3.5 27B	27B	S	378 tok/s
Qwen 3.6 27B	27B	S	238.7 tok/s

Frequently asked questions

Can AMD Instinct MI350X 288GB run CogVLM2 19B?

Yes, AMD Instinct MI350X 288GB can run CogVLM2 19B with a A grade (Runs well). Expected decode speed: 266.0 tok/s.

How much VRAM does CogVLM2 19B need?

CogVLM2 19B (19B parameters) requires approximately 43.7 GB of memory with Q4_K_M quantization.

What is the best quantization for CogVLM2 19B?

The recommended quantization for CogVLM2 19B is Q4_K_M, which balances quality and memory efficiency.

What speed will CogVLM2 19B run at on AMD Instinct MI350X 288GB?

On AMD Instinct MI350X 288GB, CogVLM2 19B achieves approximately 266.0 tokens per second decode speed with a time-to-first-token of 728ms using Q4_K_M quantization.

Can AMD Instinct MI350X 288GB run CogVLM2 19B for coding?

For coding workloads, CogVLM2 19B on AMD Instinct MI350X 288GB receives a A grade with 266.0 tok/s and 8K context.

What context window can CogVLM2 19B use on AMD Instinct MI350X 288GB?

On AMD Instinct MI350X 288GB, CogVLM2 19B can safely use up to 8K tokens of context. The model's official context limit is 8K, but available memory constrains the safe maximum.

See all results for AMD Instinct MI350X 288GB See all hardware for CogVLM2 19B

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Preview:

Workload

Grade

Fit

Decode

TTFT

Context

Chat

Runs well

266.0 tok/s

397 ms

Coding

Runs well

266.0 tok/s

728 ms

Agentic Coding

Runs well

266.0 tok/s

1059 ms

Reasoning

Runs well

266.0 tok/s

860 ms

RAG

Runs well

266.0 tok/s

1323 ms

Quantization options

How CogVLM2 19B (19B params) fits at each quantization level on AMD Instinct MI350X 288GB (288.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	7.4 GB	Low	B69
Q3_K_S	3	9.3 GB	Low	B69
NVFP4	4	10.6 GB	Medium	B69
Q4_K_M	4	11.6 GB	Medium	B69
Q5_K_M	5	13.7 GB	High	B69
Q6_K	6	15.6 GB	High	B70
Q8_0	8	20.3 GB	Very High	B70
F16Best for your GPU	16	38.9 GB	Maximum	A71

Model

Params

Grade

Decode

Capabilities

Qwen 3.5 397B A17B

397B

78.9 tok/s

Devstral 2 123B Instruct

123B

84.6 tok/s

Qwen3-Coder 30B A3B Instruct

30.5B

883.1 tok/s

Qwen 3.5 27B

27B

378 tok/s

Qwen 3.6 27B

27B

238.7 tok/s

Frequently asked questions

Can AMD Instinct MI350X 288GB run CogVLM2 19B?

Yes, AMD Instinct MI350X 288GB can run CogVLM2 19B with a A grade (Runs well). Expected decode speed: 266.0 tok/s.

How much VRAM does CogVLM2 19B need?

CogVLM2 19B (19B parameters) requires approximately 43.7 GB of memory with Q4_K_M quantization.

What is the best quantization for CogVLM2 19B?

The recommended quantization for CogVLM2 19B is Q4_K_M, which balances quality and memory efficiency.

What speed will CogVLM2 19B run at on AMD Instinct MI350X 288GB?

On AMD Instinct MI350X 288GB, CogVLM2 19B achieves approximately 266.0 tokens per second decode speed with a time-to-first-token of 728ms using Q4_K_M quantization.

Can AMD Instinct MI350X 288GB run CogVLM2 19B for coding?

For coding workloads, CogVLM2 19B on AMD Instinct MI350X 288GB receives a A grade with 266.0 tok/s and 8K context.

What context window can CogVLM2 19B use on AMD Instinct MI350X 288GB?

On AMD Instinct MI350X 288GB, CogVLM2 19B can safely use up to 8K tokens of context. The model's official context limit is 8K, but available memory constrains the safe maximum.