Can Wan Video 2.1 14B run on AMD Instinct MI325X 256GB?
YES — Runs Great
S90Excellent
Wan Video 2.1 14B needs ~56.2 GB VRAM. AMD Instinct MI325X 256GB has 256.0 GB.
56.2 GB required256.0 GB available
22% VRAM used
Parameters
14B
Precision
FP16
Max Resolution
720×1280
VRAM
56.2 GB / 256.0 GB
Gen Time
500ms/frame
Performance by workload
| Workload | Grade | Fit | VRAM | Per Frame |
|---|---|---|---|---|
| Short Clip | S | Runs natively | 56.2 GB | 500ms |
| Long Video | S | Runs natively | 79.4 GB | 700ms |
Video scenario compatibility
How Wan Video 2.1 14B (14B params) performs at each scenario on AMD Instinct MI325X 256GB (256.0 GB usable).
FP16 (full precision)
| Scenario | VRAM | AMD Instinct MI325X 256GB |
|---|---|---|
| 512×512 · 25 frames | 54.1 GB | S |
| 768×512 · 25 frames | 56.2 GB | S |
| 768×512 · 100 frames | 62.5 GB | S |
| 1280×720 · 25 frames | 64.6 GB | S |
FP8 (quantized — ~40% less VRAM)
| Scenario | VRAM | AMD Instinct MI325X 256GB |
|---|---|---|
| 512×512 · 25 frames | 29.5 GB | S |
| 768×512 · 25 frames | 31.6 GB | S |
| 768×512 · 100 frames | 37.9 GB | S |
| 1280×720 · 25 frames | 40.1 GB | S |
Memory breakdown
Required: 56.2 GBAvailable: 256.0 GB
Weights28.0 GB
VAE0.2 GB
Text Encoder18.8 GB
Activations6.0 GB
Overhead0.5 GB
Frequently asked questions
Can AMD Instinct MI325X 256GB run Wan Video 2.1 14B?
Yes, AMD Instinct MI325X 256GB can run Wan Video 2.1 14B for video generation. Runs natively.
How much VRAM does Wan Video 2.1 14B need?
Wan Video 2.1 14B (14B parameters) requires approximately 56.2 GB at FP16. AMD Instinct MI325X 256GB provides 256.0 GB.
What resolution and duration can Wan Video 2.1 14B produce on AMD Instinct MI325X 256GB?
On AMD Instinct MI325X 256GB, Wan Video 2.1 14B can generate video at up to 720x1280. Generation time is approximately 0.5 seconds per frame.
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