Can Qwen 3.5 27B run on AMD Instinct MI210 64GB?

YES — Runs Great

S92Excellent

Estimated from fit model

Qwen 3.5 27B needs ~26.9 GB VRAM. AMD Instinct MI210 64GB has 64.0 GB. With Q4_K_M quantization, expect ~68 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 26.9 GB, 73.0 tok/s, Runs well

26.9 GB required64.0 GB available

42% VRAM used

Fit status

Runs well

Decode

73.0 tok/s

TTFT

2651 ms

Safe context

131K

Memory

26.9 GB / 64.0 GB

Memory breakdown

Weights16.5 GB

KV Cache3.2 GB

Runtime0.9 GB

Headroom6.4 GB

See how fast it feels

See how fast it feelsQwen 3.5 27B on AMD Instinct MI210 64GB
1st promptCold start — includes initialization
>Write a Python function to sort a list
Here's a Python function that sorts a list using quicksort:

def quicksort(arr):
    if len(arr) <= 1:
        return arr
    pivot = arr[len(arr) // 2]
    left   = [x for x in arr if x < pivot]
    middle = [x for x in arr if x == pivot]
    right  = [x for x in arr if x > pivot]
    return quicksort(left) + middle + quicksort(right)

# Example usage
numbers = [3, 6, 8, 10, 1, 2, 1]
print(quicksort(numbers))  # [1, 1, 2, 3, 6, 8, 10]

The algorithm picks a pivot, partitions the list into smaller, equal, and larger elements, then recursively sorts each partition and concatenates the results.
2nd promptWarm — model ready, no init overhead
>Now add type hints and a docstring
def quicksort(arr: list[int]) -> list[int]:
    """Sort a list using the quicksort algorithm.

    Args:
        arr: List of integers to sort.

    Returns:
        A new sorted list.
    """
    if len(arr) <= 1:
        return arr
    pivot = arr[len(arr) // 2]
    left   = [x for x in arr if x < pivot]
    middle = [x for x in arr if x == pivot]
    right  = [x for x in arr if x > pivot]
    return quicksort(left) + middle + quicksort(right)

Added type hints for the input and return type, plus a Google-style docstring.
Estimated: 73.0 tok/s decode · 2.7s TTFT (warm) · 183 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	S	Runs well	73.0 tok/s	1446 ms	131K
Coding	S	Runs well	67.6 tok/s	2863 ms	131K
Agentic Coding	S	Runs well	73.0 tok/s	3855 ms	131K
Reasoning	S	Runs well	73.0 tok/s	3133 ms	131K
RAG	S	Runs well	73.0 tok/s	4819 ms	131K

Quantization options

How Qwen 3.5 27B (27B params) fits at each quantization level on AMD Instinct MI210 64GB (64.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	10.5 GB	Low	A84
Q3_K_S	3	13.2 GB	Low	A85
NVFP4	4	15.1 GB	Medium	A85
Q4_K_M	4	16.5 GB	Medium	S85
Q5_K_M	5	19.4 GB	High	S86
Q6_K	6	22.1 GB	High	S87
Q8_0Best for your GPU	8	28.9 GB	Very High	S88
F16	16	55.4 GB	Maximum	F0

Get started

Copy-paste commands to run Qwen 3.5 27B on your machine.

Run

ollama run qwen3.5:27b

Your hardware

More models your AMD Instinct MI210 64GB can run

Model	Params	Grade	Decode	Capabilities
Qwen3-Coder 30B A3B Instruct	30.5B	S	168.4 tok/s

Frequently asked questions

Can AMD Instinct MI210 64GB run Qwen 3.5 27B?

Yes, AMD Instinct MI210 64GB can run Qwen 3.5 27B with a S grade (Runs well). Expected decode speed: 67.6 tok/s.

How much VRAM does Qwen 3.5 27B need?

Qwen 3.5 27B (27B parameters) requires approximately 26.9 GB of memory with Q4_K_M quantization.

What is the best quantization for Qwen 3.5 27B?

The recommended quantization for Qwen 3.5 27B is Q4_K_M, which balances quality and memory efficiency.

What speed will Qwen 3.5 27B run at on AMD Instinct MI210 64GB?

On AMD Instinct MI210 64GB, Qwen 3.5 27B achieves approximately 67.6 tokens per second decode speed with a time-to-first-token of 2863ms using Q4_K_M quantization.

Can AMD Instinct MI210 64GB run Qwen 3.5 27B for coding?

For coding workloads, Qwen 3.5 27B on AMD Instinct MI210 64GB receives a S grade with 67.6 tok/s and 131K context.

What context window can Qwen 3.5 27B use on AMD Instinct MI210 64GB?

On AMD Instinct MI210 64GB, Qwen 3.5 27B can safely use up to 131K tokens of context. The model's official context limit is 131K, but available memory constrains the safe maximum.

See all results for AMD Instinct MI210 64GB See all hardware for Qwen 3.5 27B

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