Will It Run AI

Can Qwen3-Coder 480B A35B Instruct run on AMD Instinct MI350X 288GB?

BARELY — Tight on Memory

A79Great
Estimated from fit model

Qwen3-Coder 480B A35B Instruct needs ~325.4 GB VRAM. AMD Instinct MI350X 288GB has 288.0 GB. With Q4_K_M quantization, expect ~35 tok/s.

Runtime: llama.cppCapacity: OffloadBandwidth: HighStack: StandardBottleneck: Host offload
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Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 325.4 GB, 35.3 tok/s, Very compromised (needs ~33.6 GB host RAM)
325.4 GB required288.0 GB available
113% VRAM needed

37.4 GB over capacity — needs offload or smaller quantization

Fit status

Very compromised (needs ~33.6 GB host RAM)

Decode

35.3 tok/s

TTFT

5482 ms

Safe context

4K

Memory

325.4 GB / 288.0 GB

Offload

10%

Memory breakdown

Weights292.8 GB
KV Cache2.9 GB
Runtime0.9 GB
Headroom28.8 GB

See how fast it feels

See how fast it feelsQwen3-Coder 480B A35B Instruct on AMD Instinct MI350X 288GB
1st promptCold start — includes initialization
>Write a Python function to sort a list
Here's a Python function that sorts a list using quicksort: def quicksort(arr): if len(arr) <= 1: return arr pivot = arr[len(arr) // 2] left = [x for x in arr if x < pivot] middle = [x for x in arr if x == pivot] right = [x for x in arr if x > pivot] return quicksort(left) + middle + quicksort(right) # Example usage numbers = [3, 6, 8, 10, 1, 2, 1] print(quicksort(numbers)) # [1, 1, 2, 3, 6, 8, 10] The algorithm picks a pivot, partitions the list into smaller, equal, and larger elements, then recursively sorts each partition and concatenates the results.
2nd promptWarm — model ready, no init overhead
>Now add type hints and a docstring
def quicksort(arr: list[int]) -> list[int]: """Sort a list using the quicksort algorithm. Args: arr: List of integers to sort. Returns: A new sorted list. """ if len(arr) <= 1: return arr pivot = arr[len(arr) // 2] left = [x for x in arr if x < pivot] middle = [x for x in arr if x == pivot] right = [x for x in arr if x > pivot] return quicksort(left) + middle + quicksort(right) Added type hints for the input and return type, plus a Google-style docstring.
Estimated: 35.3 tok/s decode · 5.5s TTFT (warm) · 88 tok/s prefill

What limits this setup

It fits through host-memory offload, and offload is the main reason performance drops.

CPU or host-memory offload is active

About 10% of the working set spills out of accelerator memory, which usually hurts latency and sustained decode throughput.

Very little memory headroom

You can run the model, but there is not much room left for longer context, bigger batches, extra apps, or future model updates.

Best improvement path

Remove offload with more accelerator memory

Prioritize a GPU or unified-memory tier that fits the whole model natively. Removing offload usually helps more than small compute gains.

Buy headroom, not only minimum fit

A slightly larger memory tier gives you safer context growth and makes the recommendation more future-proof.

Increase host RAM if you keep offloading

This setup may need roughly 33.6 GB of extra host RAM just for the offloaded portion, before OS and other tools.

Performance by workload

WorkloadGradeFitDecodeTTFTContext
ChatAVery compromised (needs ~32.5 GB host RAM)35.6 tok/s2962 ms4K
CodingAVery compromised (needs ~33.6 GB host RAM)35.3 tok/s5482 ms4K
Agentic CodingAVery compromised (needs ~35.9 GB host RAM)34.7 tok/s8122 ms4K
ReasoningAVery compromised (needs ~33.6 GB host RAM)35.3 tok/s6478 ms4K
RAGAVery compromised (needs ~35.9 GB host RAM)34.7 tok/s10152 ms4K

Quantization options

How Qwen3-Coder 480B A35B Instruct (480B params) fits at each quantization level on AMD Instinct MI350X 288GB (288.0 GB usable).

QuantBitsVRAMQualityFit
Q2_KBest for your GPU
2
187.2 GB
LowS86
Q3_K_S
3
235.2 GB
LowF0
NVFP4
4
268.8 GB
MediumF0
Q4_K_M
4
292.8 GB
MediumF0
Q5_K_M
5
345.6 GB
HighF0
Q6_K
6
393.6 GB
HighF0
Q8_0
8
513.6 GB
Very HighF0
F16
16
984.0 GB
MaximumF0

Get started

Copy-paste commands to run Qwen3-Coder 480B A35B Instruct on your machine.

Run

lms load Qwen3-Coder-480B-A35B-Instruct && lms server start

Frequently asked questions

Can AMD Instinct MI350X 288GB run Qwen3-Coder 480B A35B Instruct?

Yes, AMD Instinct MI350X 288GB can run Qwen3-Coder 480B A35B Instruct with a A grade (Very compromised (needs ~33.6 GB host RAM)). Expected decode speed: 35.3 tok/s.

How much VRAM does Qwen3-Coder 480B A35B Instruct need?

Qwen3-Coder 480B A35B Instruct (480B parameters) requires approximately 325.4 GB of memory with Q4_K_M quantization.

What is the best quantization for Qwen3-Coder 480B A35B Instruct?

The recommended quantization for Qwen3-Coder 480B A35B Instruct is Q4_K_M, which balances quality and memory efficiency.

What speed will Qwen3-Coder 480B A35B Instruct run at on AMD Instinct MI350X 288GB?

On AMD Instinct MI350X 288GB, Qwen3-Coder 480B A35B Instruct achieves approximately 35.3 tokens per second decode speed with a time-to-first-token of 5482ms using Q4_K_M quantization.

Can AMD Instinct MI350X 288GB run Qwen3-Coder 480B A35B Instruct for coding?

For coding workloads, Qwen3-Coder 480B A35B Instruct on AMD Instinct MI350X 288GB receives a A grade with 35.3 tok/s and 4K context.

What context window can Qwen3-Coder 480B A35B Instruct use on AMD Instinct MI350X 288GB?

On AMD Instinct MI350X 288GB, Qwen3-Coder 480B A35B Instruct can safely use up to 4K tokens of context. The model's official context limit is 256K, but available memory constrains the safe maximum.

What should I upgrade first if Qwen3-Coder 480B A35B Instruct feels slow on AMD Instinct MI350X 288GB?

Remove offload with more accelerator memory. Prioritize a GPU or unified-memory tier that fits the whole model natively. Removing offload usually helps more than small compute gains.

See all results for AMD Instinct MI350X 288GBSee all hardware for Qwen3-Coder 480B A35B Instruct
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