Can Nemotron 70B run on AMD Instinct MI325X 256GB?

YES — Runs Great

B70Good

Estimated from fit model

Nemotron 70B needs ~74.1 GB VRAM. AMD Instinct MI325X 256GB has 256.0 GB. With Q4_K_M quantization, expect ~112 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 74.1 GB, 111.6 tok/s, Runs well

74.1 GB required256.0 GB available

29% VRAM used

Fit status

Runs well

Decode

111.6 tok/s

TTFT

1736 ms

Safe context

131K

Memory

74.1 GB / 256.0 GB

Memory breakdown

Weights42.7 GB

KV Cache4.9 GB

Runtime0.9 GB

Headroom25.6 GB

See how fast it feels

See how fast it feelsNemotron 70B on AMD Instinct MI325X 256GB
1st promptCold start — includes initialization
>Solve: If a train travels at 60 mph for 2.5 hours, how far does it go?
Let me work through this step by step.

Given information:
  - Speed = 60 mph (miles per hour)
  - Time  = 2.5 hours

Formula: Distance = Speed x Time

Calculation:
  Distance = 60 mph x 2.5 h
           = 150 miles

The train travels 150 miles.

Double-check: at 60 mph the train covers 60 miles each hour. In half an hour it covers 30 miles. So in 2.5 hours: 60 + 60 + 30 = 150 miles. Confirmed.
2nd promptWarm — model ready, no init overhead
>What if the train stops for 20 minutes halfway?
The stop doesn't change the total distance covered while moving, but it affects total trip time.

Breakdown:
  - First half: 1.25 hours at 60 mph = 75 miles
  - Stop: 20 minutes (no distance)
  - Second half: 1.25 hours at 60 mph = 75 miles

Total distance: 150 miles (same)
Total time: 2.5 h + 0.33 h = 2.83 hours
Average speed: 150 / 2.83 = 53 mph

The distance stays the same but average speed drops to 53 mph because of the stop.
Estimated: 111.6 tok/s decode · 1.7s TTFT (warm) · 279 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	B	Runs well	111.6 tok/s	947 ms	131K
Coding	B	Runs well	111.6 tok/s	1736 ms	131K
Agentic Coding	A	Runs well	111.6 tok/s	2524 ms	131K
Reasoning	B	Runs well	111.6 tok/s	2051 ms	131K
RAG	A	Runs well	111.6 tok/s	3155 ms	131K

Quantization options

How Nemotron 70B (70B params) fits at each quantization level on AMD Instinct MI325X 256GB (256.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	27.3 GB	Low	B59
Q3_K_S	3	34.3 GB	Low	B60
NVFP4	4	39.2 GB	Medium	B60
Q4_K_M	4	42.7 GB	Medium	B61
Q5_K_M	5	50.4 GB	High	B61
Q6_K	6	57.4 GB	High	B62
Q8_0	8	74.9 GB	Very High	B63
F16Best for your GPU	16	143.5 GB	Maximum	B69

Get started

Copy-paste commands to run Nemotron 70B on your machine.

Run

ollama run nemotron

Frequently asked questions

Can AMD Instinct MI325X 256GB run Nemotron 70B?

Yes, AMD Instinct MI325X 256GB can run Nemotron 70B with a B grade (Runs well). Expected decode speed: 111.6 tok/s.

How much VRAM does Nemotron 70B need?

Nemotron 70B (70B parameters) requires approximately 74.1 GB of memory with Q4_K_M quantization.

What is the best quantization for Nemotron 70B?

The recommended quantization for Nemotron 70B is Q4_K_M, which balances quality and memory efficiency.

What speed will Nemotron 70B run at on AMD Instinct MI325X 256GB?

On AMD Instinct MI325X 256GB, Nemotron 70B achieves approximately 111.6 tokens per second decode speed with a time-to-first-token of 1736ms using Q4_K_M quantization.

Can AMD Instinct MI325X 256GB run Nemotron 70B for coding?

For coding workloads, Nemotron 70B on AMD Instinct MI325X 256GB receives a B grade with 111.6 tok/s and 131K context.

What context window can Nemotron 70B use on AMD Instinct MI325X 256GB?

On AMD Instinct MI325X 256GB, Nemotron 70B can safely use up to 131K tokens of context. The model's official context limit is 131K, but available memory constrains the safe maximum.

See all results for AMD Instinct MI325X 256GB See all hardware for Nemotron 70B

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