Can Llama 3.3 70B Instruct run on AMD Instinct MI325X 256GB?

YES — Runs Great

C48Usable

Estimated from fit model

Llama 3.3 70B Instruct needs ~77.4 GB VRAM. AMD Instinct MI325X 256GB has 256.0 GB. With Q4_K_M quantization, expect ~103 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 77.4 GB, 102.6 tok/s, Runs well

77.4 GB required256.0 GB available

30% VRAM used

Fit status

Runs well

Decode

102.6 tok/s

TTFT

1887 ms

Safe context

364K

Memory

77.4 GB / 256.0 GB

Memory breakdown

Weights42.7 GB

KV Cache8.2 GB

Runtime0.9 GB

Headroom25.6 GB

See how fast it feels

See how fast it feelsLlama 3.3 70B Instruct on AMD Instinct MI325X 256GB
1st promptCold start — includes initialization
>What is local AI inference?
Local AI inference means running an AI language model directly on your own hardware — your laptop, desktop, or server — instead of sending requests to a remote cloud API.

When you run inference locally the model weights are loaded into your GPU or unified memory. Each token you generate requires reading those weights from memory, so memory bandwidth is the main bottleneck for decode speed.

Key benefits of running locally:
  - Full privacy: your prompts never leave your machine
  - No per-token cost or rate limits
  - Works offline once the model is downloaded
  - Latency depends only on your hardware
2nd promptWarm — model ready, no init overhead
>How much VRAM do I need?
It depends on the model size and quantization level. A rough rule of thumb:

  Model size     Q4 (4-bit)    Q8 (8-bit)    FP16
  7B params      ~4.3 GB       ~7.5 GB       ~14 GB
  13B params     ~7.9 GB       ~13.9 GB      ~26 GB
  70B params     ~42.7 GB      ~74.9 GB      ~140 GB

Most people use 4-bit quantization (Q4_K_M) which gives 90-95% of full quality at a fraction of the memory. A 24 GB GPU can comfortably run most 7B-13B models.
Estimated: 102.6 tok/s decode · 1.9s TTFT (warm) · 256 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	C	Runs well	102.6 tok/s	1029 ms	364K
Coding	C	Runs well	102.6 tok/s	1887 ms	364K
Agentic Coding	C	Runs well	102.6 tok/s	2745 ms	364K
Reasoning	C	Runs well	102.6 tok/s	2231 ms	364K
RAG	C	Runs well	102.6 tok/s	3432 ms	364K

Quantization options

How Llama 3.3 70B Instruct (70B params) fits at each quantization level on AMD Instinct MI325X 256GB (256.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	27.3 GB	Low	D38
Q3_K_S	3	34.3 GB	Low	D38
NVFP4	4	39.2 GB	Medium	D39
Q4_K_M	4	42.7 GB	Medium	D39
Q5_K_M	5	50.4 GB	High	D40
Q6_K	6	57.4 GB	High	C40
Q8_0	8	74.9 GB	Very High	C42
F16Best for your GPU	16	143.5 GB	Maximum	C48

Get started

Copy-paste commands to run Llama 3.3 70B Instruct on your machine.

Run

lms load hf-maziyarpanahi--llama-3-3-70b-instruct-gguf && lms server start

Frequently asked questions

Can AMD Instinct MI325X 256GB run Llama 3.3 70B Instruct?

Yes, AMD Instinct MI325X 256GB can run Llama 3.3 70B Instruct with a C grade (Runs well). Expected decode speed: 102.6 tok/s.

How much VRAM does Llama 3.3 70B Instruct need?

Llama 3.3 70B Instruct (70B parameters) requires approximately 77.4 GB of memory with Q4_K_M quantization.

What is the best quantization for Llama 3.3 70B Instruct?

The recommended quantization for Llama 3.3 70B Instruct is Q4_K_M, which balances quality and memory efficiency.

What speed will Llama 3.3 70B Instruct run at on AMD Instinct MI325X 256GB?

On AMD Instinct MI325X 256GB, Llama 3.3 70B Instruct achieves approximately 102.6 tokens per second decode speed with a time-to-first-token of 1887ms using Q4_K_M quantization.

Can AMD Instinct MI325X 256GB run Llama 3.3 70B Instruct for coding?

For coding workloads, Llama 3.3 70B Instruct on AMD Instinct MI325X 256GB receives a C grade with 102.6 tok/s and 364K context.

What context window can Llama 3.3 70B Instruct use on AMD Instinct MI325X 256GB?

On AMD Instinct MI325X 256GB, Llama 3.3 70B Instruct can safely use up to 364K tokens of context. The model's official context limit is —, but available memory constrains the safe maximum.

See all results for AMD Instinct MI325X 256GB See all hardware for Llama 3.3 70B Instruct

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