Can Nemotron 70B run on AMD Instinct MI350X 288GB?

YES — Runs Great

B69Good

Estimated from fit model

Nemotron 70B needs ~77.3 GB VRAM. AMD Instinct MI350X 288GB has 288.0 GB. With Q4_K_M quantization, expect ~149 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 77.3 GB, 148.7 tok/s, Runs well

77.3 GB required288.0 GB available

27% VRAM used

Fit status

Runs well

Decode

148.7 tok/s

TTFT

1302 ms

Safe context

131K

Memory

77.3 GB / 288.0 GB

Memory breakdown

Weights42.7 GB

KV Cache4.9 GB

Runtime0.9 GB

Headroom28.8 GB

See how fast it feels

See how fast it feelsNemotron 70B on AMD Instinct MI350X 288GB
1st promptCold start — includes initialization
>Solve: If a train travels at 60 mph for 2.5 hours, how far does it go?
Let me work through this step by step.

Given information:
  - Speed = 60 mph (miles per hour)
  - Time  = 2.5 hours

Formula: Distance = Speed x Time

Calculation:
  Distance = 60 mph x 2.5 h
           = 150 miles

The train travels 150 miles.

Double-check: at 60 mph the train covers 60 miles each hour. In half an hour it covers 30 miles. So in 2.5 hours: 60 + 60 + 30 = 150 miles. Confirmed.
2nd promptWarm — model ready, no init overhead
>What if the train stops for 20 minutes halfway?
The stop doesn't change the total distance covered while moving, but it affects total trip time.

Breakdown:
  - First half: 1.25 hours at 60 mph = 75 miles
  - Stop: 20 minutes (no distance)
  - Second half: 1.25 hours at 60 mph = 75 miles

Total distance: 150 miles (same)
Total time: 2.5 h + 0.33 h = 2.83 hours
Average speed: 150 / 2.83 = 53 mph

The distance stays the same but average speed drops to 53 mph because of the stop.
Estimated: 148.7 tok/s decode · 1.3s TTFT (warm) · 372 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	B	Runs well	148.7 tok/s	710 ms	131K
Coding	B	Runs well	148.7 tok/s	1302 ms	131K
Agentic Coding	B	Runs well	148.7 tok/s	1893 ms	131K
Reasoning	B	Runs well	148.7 tok/s	1538 ms	131K
RAG	B	Runs well	148.7 tok/s	2367 ms	131K

Inference speed

Nemotron 70B inference speed — tokens per second by GPU & Mac

Estimated decode speed (tokens/sec) for Nemotron 70B at Q4_K_M across popular GPUs and Apple Silicon, including multi-GPU rigs, using the fastest local runtime per device. Fastest is 2× RX 7900 XTX 24GB at ~18 tok/s. Speed is memory-bandwidth bound, so cards that fit the whole model in VRAM run far faster than ones that offload to system RAM.

GPU / Mac	Memory	Quant	Speed (tok/s)	Fits?
2× RX 7900 XTX 24GB	48 GB	Q4_K_M	18.0	Heavy offload
MacBook Pro M4 Max 128GB	128 GB	Q4_K_M	16.5	Fits
Mac Studio M3 Ultra 256GB	256 GB	Q4_K_M	14.2	Fits
MacBook Pro M4 Max 64GB	64 GB	Q4_K_M	12.6	Too big
Mac Studio M2 Ultra 128GB	128 GB	Q4_K_M	11.8	Fits
Mac Studio M1 Ultra 128GB	128 GB	Q4_K_M	11.2	Fits
2× RTX 4090 24GB	48 GB	Q4_K_M	9.5	Heavy offload
2× RTX 3090 24GB	48 GB	Q4_K_M	8.7	Heavy offload
4× RTX 3060 12GB	48 GB	Q4_K_M	7.7	Heavy offload
MacBook Pro M4 Pro 48GB	48 GB	Q4_K_M	5.9	Too big
RTX 5090 32GB	32 GB	Q4_K_M	5.7	Too big
MacBook Pro M3 Max 64GB	64 GB	Q4_K_M	4.6	Too big
MacBook Pro M1 Max 64GB	64 GB	Q4_K_M	4.3	Too big
RX 7900 XTX 24GB	24 GB	Q4_K_M	2.7	Too big
RTX 4090 24GB	24 GB	Q4_K_M	2.0	Too big
RTX 4080 Super 16GB	16 GB	Q4_K_M	2.0	Too big
RTX 3090 24GB	24 GB	Q4_K_M	2.0	Too big
RTX 4070 12GB	12 GB	Q4_K_M	2.0	Too big
RTX 3060 12GB	12 GB	Q4_K_M	2.0	Too big
RTX 4060 8GB	8 GB	Q4_K_M	2.0	Too big

Estimates for single-stream decoding at Q4_K_M; real tokens/sec varies with prompt length, context, batch size, and runtime build. Prompt processing (prefill) is faster than the decode figures shown here.

Quantization options

How Nemotron 70B (70B params) fits at each quantization level on AMD Instinct MI350X 288GB (288.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	27.3 GB	Low	B59
Q3_K_S	3	34.3 GB	Low	B60
NVFP4	4	39.2 GB	Medium	B60
Q4_K_M	4	42.7 GB	Medium	B60
Q5_K_M	5	50.4 GB	High	B61
Q6_K	6	57.4 GB	High	B61
Q8_0	8	74.9 GB	Very High	B63
F16Best for your GPU	16	143.5 GB	Maximum	B68

Get started

Copy-paste commands to run Nemotron 70B on your machine.

Run

ollama run nemotron

Frequently asked questions

Can AMD Instinct MI350X 288GB run Nemotron 70B?

Yes, AMD Instinct MI350X 288GB can run Nemotron 70B with a B grade (Runs well). Expected decode speed: 148.7 tok/s.

How much VRAM does Nemotron 70B need?

Nemotron 70B (70B parameters) requires approximately 77.3 GB of memory with Q4_K_M quantization.

What is the best quantization for Nemotron 70B?

The recommended quantization for Nemotron 70B is Q4_K_M, which balances quality and memory efficiency.

What speed will Nemotron 70B run at on AMD Instinct MI350X 288GB?

On AMD Instinct MI350X 288GB, Nemotron 70B achieves approximately 148.7 tokens per second decode speed with a time-to-first-token of 1302ms using Q4_K_M quantization.

Can AMD Instinct MI350X 288GB run Nemotron 70B for coding?

For coding workloads, Nemotron 70B on AMD Instinct MI350X 288GB receives a B grade with 148.7 tok/s and 131K context.

What context window can Nemotron 70B use on AMD Instinct MI350X 288GB?

On AMD Instinct MI350X 288GB, Nemotron 70B can safely use up to 131K tokens of context. The model's official context limit is 131K, but available memory constrains the safe maximum.

See all results for AMD Instinct MI350X 288GB See all hardware for Nemotron 70B

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