Can LTX-2 22B run on AMD Instinct MI250X 128GB?
YES — Runs Great
S90Excellent
LTX-2 22B needs ~63.9 GB VRAM. AMD Instinct MI250X 128GB has 128.0 GB.
| Precision | VRAM Needed | Status | Grade |
|---|---|---|---|
| FP16Best | 63.9 GB | Runs natively | S |
| FP8 | 35.9 GB | Runs natively | S |
63.9 GB required128.0 GB available
50% VRAM used
Parameters
22B
Precision
FP16
Max Resolution
1920×1088
VRAM
63.9 GB / 128.0 GB
Gen Time
~1.9s/frame
Performance by workload
| Workload | Grade | Fit | VRAM | Per Frame |
|---|---|---|---|---|
| Short Clip | S | Runs natively | 63.9 GB | ~1.9s |
| Long Video | S | Runs natively | 87.2 GB | ~2.6s |
Video scenario compatibility
How LTX-2 22B (22B params) performs at each scenario on AMD Instinct MI250X 128GB (128.0 GB usable).
FP16 (full precision)
| Scenario | VRAM | AMD Instinct MI250X 128GB |
|---|---|---|
| 512×512 · 25 frames | 61.8 GB | S |
| 768×512 · 25 frames | 63.9 GB | S |
| 768×512 · 100 frames | 70.2 GB | S |
| 1280×720 · 25 frames | 72.4 GB | S |
FP8 (quantized — ~40% less VRAM)
| Scenario | VRAM | AMD Instinct MI250X 128GB |
|---|---|---|
| 512×512 · 25 frames | 33.8 GB | S |
| 768×512 · 25 frames | 35.9 GB | S |
| 768×512 · 100 frames | 42.2 GB | S |
| 1280×720 · 25 frames | 44.4 GB | S |
Memory breakdown
Required: 63.9 GBAvailable: 128.0 GB
Weights44.0 GB
VAE1.0 GB
Text Encoder9.4 GB
Activations6.0 GB
Overhead0.5 GB
Frequently asked questions
Can AMD Instinct MI250X 128GB run LTX-2 22B?
Yes, AMD Instinct MI250X 128GB can run LTX-2 22B for video generation. Runs natively.
How much VRAM does LTX-2 22B need?
LTX-2 22B (22B parameters) requires approximately 63.9 GB at FP16. AMD Instinct MI250X 128GB provides 128.0 GB.
What resolution and duration can LTX-2 22B produce on AMD Instinct MI250X 128GB?
On AMD Instinct MI250X 128GB, LTX-2 22B can generate video at up to 1920x1088. Generation time is approximately 1.9 seconds per frame.
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<iframe src="https://willitrunai.com/embed/ltx-2-3-on-instinct-mi250x-128gb" width="400" height="180" frameborder="0" style="border:none;border-radius:12px;overflow:hidden;" title="Will It Run AI — fit result"></iframe>
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