Can Codestral 22B v0.1 run on AMD Instinct MI250X 128GB?

YES — Runs Great

C47Usable

Estimated from fit model

Codestral 22B v0.1 needs ~29.7 GB VRAM. AMD Instinct MI250X 128GB has 128.0 GB. With Q4_K_M quantization, expect ~186 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 29.7 GB, 186.0 tok/s, Runs well

29.7 GB required128.0 GB available

23% VRAM used

Fit status

Runs well

Decode

186.0 tok/s

TTFT

1041 ms

Safe context

626K

Memory

29.7 GB / 128.0 GB

Memory breakdown

Weights13.4 GB

KV Cache2.6 GB

Runtime0.9 GB

Headroom12.8 GB

See how fast it feels

See how fast it feelsCodestral 22B v0.1 on AMD Instinct MI250X 128GB
1st promptCold start — includes initialization
>Write a Python function to sort a list
Here's a Python function that sorts a list using quicksort:

def quicksort(arr):
    if len(arr) <= 1:
        return arr
    pivot = arr[len(arr) // 2]
    left   = [x for x in arr if x < pivot]
    middle = [x for x in arr if x == pivot]
    right  = [x for x in arr if x > pivot]
    return quicksort(left) + middle + quicksort(right)

# Example usage
numbers = [3, 6, 8, 10, 1, 2, 1]
print(quicksort(numbers))  # [1, 1, 2, 3, 6, 8, 10]

The algorithm picks a pivot, partitions the list into smaller, equal, and larger elements, then recursively sorts each partition and concatenates the results.
2nd promptWarm — model ready, no init overhead
>Now add type hints and a docstring
def quicksort(arr: list[int]) -> list[int]:
    """Sort a list using the quicksort algorithm.

    Args:
        arr: List of integers to sort.

    Returns:
        A new sorted list.
    """
    if len(arr) <= 1:
        return arr
    pivot = arr[len(arr) // 2]
    left   = [x for x in arr if x < pivot]
    middle = [x for x in arr if x == pivot]
    right  = [x for x in arr if x > pivot]
    return quicksort(left) + middle + quicksort(right)

Added type hints for the input and return type, plus a Google-style docstring.
Estimated: 186.0 tok/s decode · 1.0s TTFT (warm) · 465 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	C	Runs well	186.0 tok/s	568 ms	626K
Coding	C	Runs well	186.0 tok/s	1041 ms	626K
Agentic Coding	C	Runs well	186.0 tok/s	1514 ms	626K
Reasoning	C	Runs well	186.0 tok/s	1230 ms	626K
RAG	C	Runs well	186.0 tok/s	1893 ms	626K

Quantization options

How Codestral 22B v0.1 (22B params) fits at each quantization level on AMD Instinct MI250X 128GB (128.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	8.6 GB	Low	D38
Q3_K_S	3	10.8 GB	Low	D38
NVFP4	4	12.3 GB	Medium	D38
Q4_K_M	4	13.4 GB	Medium	D38
Q5_K_M	5	15.8 GB	High	D38
Q6_K	6	18.0 GB	High	D39
Q8_0	8	23.5 GB	Very High	D39
F16Best for your GPU	16	45.1 GB	Maximum	C43

Get started

Copy-paste commands to run Codestral 22B v0.1 on your machine.

Run

lms load hf-sanctumai--codestral-22b-v0-1-gguf && lms server start

Frequently asked questions

Can AMD Instinct MI250X 128GB run Codestral 22B v0.1?

Yes, AMD Instinct MI250X 128GB can run Codestral 22B v0.1 with a C grade (Runs well). Expected decode speed: 186.0 tok/s.

How much VRAM does Codestral 22B v0.1 need?

Codestral 22B v0.1 (22B parameters) requires approximately 29.7 GB of memory with Q4_K_M quantization.

What is the best quantization for Codestral 22B v0.1?

The recommended quantization for Codestral 22B v0.1 is Q4_K_M, which balances quality and memory efficiency.

What speed will Codestral 22B v0.1 run at on AMD Instinct MI250X 128GB?

On AMD Instinct MI250X 128GB, Codestral 22B v0.1 achieves approximately 186.0 tokens per second decode speed with a time-to-first-token of 1041ms using Q4_K_M quantization.

Can AMD Instinct MI250X 128GB run Codestral 22B v0.1 for coding?

For coding workloads, Codestral 22B v0.1 on AMD Instinct MI250X 128GB receives a C grade with 186.0 tok/s and 626K context.

What context window can Codestral 22B v0.1 use on AMD Instinct MI250X 128GB?

On AMD Instinct MI250X 128GB, Codestral 22B v0.1 can safely use up to 626K tokens of context. The model's official context limit is —, but available memory constrains the safe maximum.

See all results for AMD Instinct MI250X 128GB See all hardware for Codestral 22B v0.1

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