Can Qwen 2.5 Math 72B run on AMD Instinct MI350X 288GB?

YES — Runs Great

B61Good

Estimated from fit model

Qwen 2.5 Math 72B needs ~78.5 GB VRAM. AMD Instinct MI350X 288GB has 288.0 GB. With Q4_K_M quantization, expect ~133 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 78.5 GB, 144.6 tok/s, Runs well

78.5 GB required288.0 GB available

27% VRAM used

Fit status

Runs well

Decode

144.6 tok/s

TTFT

1339 ms

Safe context

Memory

78.5 GB / 288.0 GB

Memory breakdown

Weights43.9 GB

KV Cache4.9 GB

Runtime0.9 GB

Headroom28.8 GB

See how fast it feels

See how fast it feelsQwen 2.5 Math 72B on AMD Instinct MI350X 288GB
1st promptCold start — includes initialization
>Solve: If a train travels at 60 mph for 2.5 hours, how far does it go?
Let me work through this step by step.

Given information:
  - Speed = 60 mph (miles per hour)
  - Time  = 2.5 hours

Formula: Distance = Speed x Time

Calculation:
  Distance = 60 mph x 2.5 h
           = 150 miles

The train travels 150 miles.

Double-check: at 60 mph the train covers 60 miles each hour. In half an hour it covers 30 miles. So in 2.5 hours: 60 + 60 + 30 = 150 miles. Confirmed.
2nd promptWarm — model ready, no init overhead
>What if the train stops for 20 minutes halfway?
The stop doesn't change the total distance covered while moving, but it affects total trip time.

Breakdown:
  - First half: 1.25 hours at 60 mph = 75 miles
  - Stop: 20 minutes (no distance)
  - Second half: 1.25 hours at 60 mph = 75 miles

Total distance: 150 miles (same)
Total time: 2.5 h + 0.33 h = 2.83 hours
Average speed: 150 / 2.83 = 53 mph

The distance stays the same but average speed drops to 53 mph because of the stop.
Estimated: 144.6 tok/s decode · 1.3s TTFT (warm) · 362 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	B	Runs well	144.6 tok/s	730 ms	4K
Coding	B	Runs well	133.0 tok/s	1456 ms	4K
Agentic Coding	B	Runs well	144.6 tok/s	1947 ms	4K
Reasoning	B	Runs well	144.6 tok/s	1582 ms	4K
RAG	B	Runs well	144.6 tok/s	2434 ms	4K

Quantization options

How Qwen 2.5 Math 72B (72B params) fits at each quantization level on AMD Instinct MI350X 288GB (288.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	28.1 GB	Low	C51
Q3_K_S	3	35.3 GB	Low	C51
NVFP4	4	40.3 GB	Medium	C52
Q4_K_M	4	43.9 GB	Medium	C52
Q5_K_M	5	51.8 GB	High	C53
Q6_K	6	59.0 GB	High	C53
Q8_0	8	77.0 GB	Very High	C54
F16Best for your GPU	16	147.6 GB	Maximum	B60

Get started

Copy-paste commands to run Qwen 2.5 Math 72B on your machine.

Run

docker run --rm -it ghcr.io/ggerganov/llama.cpp:full \
  --hf-repo "Qwen/Qwen2.5-Math-72B-Instruct" \
  --hf-file "Qwen2.5-Math-72B-Instruct-Q4_K_M.gguf" \
  -c 4096 -ngl 99

Frequently asked questions

Can AMD Instinct MI350X 288GB run Qwen 2.5 Math 72B?

Yes, AMD Instinct MI350X 288GB can run Qwen 2.5 Math 72B with a B grade (Runs well). Expected decode speed: 133.0 tok/s.

How much VRAM does Qwen 2.5 Math 72B need?

Qwen 2.5 Math 72B (72B parameters) requires approximately 78.5 GB of memory with Q4_K_M quantization.

What is the best quantization for Qwen 2.5 Math 72B?

The recommended quantization for Qwen 2.5 Math 72B is Q4_K_M, which balances quality and memory efficiency.

What speed will Qwen 2.5 Math 72B run at on AMD Instinct MI350X 288GB?

On AMD Instinct MI350X 288GB, Qwen 2.5 Math 72B achieves approximately 133.0 tokens per second decode speed with a time-to-first-token of 1456ms using Q4_K_M quantization.

Can AMD Instinct MI350X 288GB run Qwen 2.5 Math 72B for coding?

For coding workloads, Qwen 2.5 Math 72B on AMD Instinct MI350X 288GB receives a B grade with 133.0 tok/s and 4K context.

What context window can Qwen 2.5 Math 72B use on AMD Instinct MI350X 288GB?

On AMD Instinct MI350X 288GB, Qwen 2.5 Math 72B can safely use up to 4K tokens of context. The model's official context limit is 4K, but available memory constrains the safe maximum.

See all results for AMD Instinct MI350X 288GB See all hardware for Qwen 2.5 Math 72B

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