Will It Run AI

Can Mixtral 8x22B run on AMD Instinct MI350X 288GB?

YES — Runs Great

B64Good
Estimated from fit model

Mixtral 8x22B needs ~119.1 GB VRAM. AMD Instinct MI350X 288GB has 288.0 GB. With Q4_K_M quantization, expect ~141 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced
Share:

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 119.1 GB, 141.1 tok/s, Runs well
119.1 GB required288.0 GB available
41% VRAM used

Fit status

Runs well

Decode

141.1 tok/s

TTFT

1372 ms

Safe context

66K

Memory

119.1 GB / 288.0 GB

Memory breakdown

Weights86.0 GB
KV Cache3.4 GB
Runtime0.9 GB
Headroom28.8 GB

See how fast it feels

See how fast it feelsMixtral 8x22B on AMD Instinct MI350X 288GB
1st promptCold start — includes initialization
>Solve: If a train travels at 60 mph for 2.5 hours, how far does it go?
Let me work through this step by step. Given information: - Speed = 60 mph (miles per hour) - Time = 2.5 hours Formula: Distance = Speed x Time Calculation: Distance = 60 mph x 2.5 h = 150 miles The train travels 150 miles. Double-check: at 60 mph the train covers 60 miles each hour. In half an hour it covers 30 miles. So in 2.5 hours: 60 + 60 + 30 = 150 miles. Confirmed.
2nd promptWarm — model ready, no init overhead
>What if the train stops for 20 minutes halfway?
The stop doesn't change the total distance covered while moving, but it affects total trip time. Breakdown: - First half: 1.25 hours at 60 mph = 75 miles - Stop: 20 minutes (no distance) - Second half: 1.25 hours at 60 mph = 75 miles Total distance: 150 miles (same) Total time: 2.5 h + 0.33 h = 2.83 hours Average speed: 150 / 2.83 = 53 mph The distance stays the same but average speed drops to 53 mph because of the stop.
Estimated: 141.1 tok/s decode · 1.4s TTFT (warm) · 353 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

WorkloadGradeFitDecodeTTFTContext
ChatBRuns well141.1 tok/s748 ms66K
CodingBRuns well141.1 tok/s1372 ms66K
Agentic CodingBRuns well141.1 tok/s1996 ms66K
ReasoningBRuns well141.1 tok/s1621 ms66K
RAGBRuns well141.1 tok/s2495 ms66K

Quantization options

How Mixtral 8x22B (141B params) fits at each quantization level on AMD Instinct MI350X 288GB (288.0 GB usable).

QuantBitsVRAMQualityFit
Q2_K
2
55.0 GB
LowC53
Q3_K_S
3
69.1 GB
LowC54
NVFP4
4
79.0 GB
MediumB55
Q4_K_M
4
86.0 GB
MediumB56
Q5_K_M
5
101.5 GB
HighB57
Q6_K
6
115.6 GB
HighB58
Q8_0Best for your GPU
8
150.9 GB
Very HighB60
F16
16
289.0 GB
MaximumF0

Get started

Copy-paste commands to run Mixtral 8x22B on your machine.

Run

ollama run mixtral:8x22b

Frequently asked questions

Can AMD Instinct MI350X 288GB run Mixtral 8x22B?

Yes, AMD Instinct MI350X 288GB can run Mixtral 8x22B with a B grade (Runs well). Expected decode speed: 141.1 tok/s.

How much VRAM does Mixtral 8x22B need?

Mixtral 8x22B (141B parameters) requires approximately 119.1 GB of memory with Q4_K_M quantization.

What is the best quantization for Mixtral 8x22B?

The recommended quantization for Mixtral 8x22B is Q4_K_M, which balances quality and memory efficiency.

What speed will Mixtral 8x22B run at on AMD Instinct MI350X 288GB?

On AMD Instinct MI350X 288GB, Mixtral 8x22B achieves approximately 141.1 tokens per second decode speed with a time-to-first-token of 1372ms using Q4_K_M quantization.

Can AMD Instinct MI350X 288GB run Mixtral 8x22B for coding?

For coding workloads, Mixtral 8x22B on AMD Instinct MI350X 288GB receives a B grade with 141.1 tok/s and 66K context.

What context window can Mixtral 8x22B use on AMD Instinct MI350X 288GB?

On AMD Instinct MI350X 288GB, Mixtral 8x22B can safely use up to 66K tokens of context. The model's official context limit is 66K, but available memory constrains the safe maximum.

See all results for AMD Instinct MI350X 288GBSee all hardware for Mixtral 8x22B
Embed this result▼

Paste this snippet into any page to show a live fit card.

<iframe src="https://willitrunai.com/embed/mixtral-8x22b-on-instinct-mi350x-288gb" width="400" height="180" frameborder="0" style="border:none;border-radius:12px;overflow:hidden;" title="Will It Run AI — fit result"></iframe>

Preview: