Can Qwen3.5 122B A10B run on AMD Instinct MI350X 288GB?

YES — Runs Great

C50Usable

Estimated from fit model

Qwen3.5 122B A10B needs ~103.8 GB VRAM. AMD Instinct MI350X 288GB has 288.0 GB. With Q3_K_M quantization, expect ~91 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

F16 (Maximum quality) — 294.1 GB, 23.5 tok/s, Runs with offload (needs ~5.2 GB host RAM)

294.1 GB required288.0 GB available

102% VRAM needed

6.1 GB over capacity — needs offload or smaller quantization

Fit status

Runs with offload (needs ~5.2 GB host RAM)

Decode

23.5 tok/s

TTFT

8252 ms

Safe context

Memory

294.1 GB / 288.0 GB

Memory breakdown

Weights250.1 GB

KV Cache14.3 GB

Runtime0.9 GB

Headroom28.8 GB

See how fast it feels

See how fast it feelsQwen3.5 122B A10B on AMD Instinct MI350X 288GB
1st promptCold start — includes initialization
>What is local AI inference?
Local AI inference means running an AI language model directly on your own hardware — your laptop, desktop, or server — instead of sending requests to a remote cloud API.

When you run inference locally the model weights are loaded into your GPU or unified memory. Each token you generate requires reading those weights from memory, so memory bandwidth is the main bottleneck for decode speed.

Key benefits of running locally:
  - Full privacy: your prompts never leave your machine
  - No per-token cost or rate limits
  - Works offline once the model is downloaded
  - Latency depends only on your hardware
2nd promptWarm — model ready, no init overhead
>How much VRAM do I need?
It depends on the model size and quantization level. A rough rule of thumb:

  Model size     Q4 (4-bit)    Q8 (8-bit)    FP16
  7B params      ~4.3 GB       ~7.5 GB       ~14 GB
  13B params     ~7.9 GB       ~13.9 GB      ~26 GB
  70B params     ~42.7 GB      ~74.9 GB      ~140 GB

Most people use 4-bit quantization (Q4_K_M) which gives 90-95% of full quality at a fraction of the memory. A 24 GB GPU can comfortably run most 7B-13B models.
Estimated: 23.5 tok/s decode · 8.3s TTFT (warm) · 59 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	C	Runs well	90.9 tok/s	1162 ms	222K
Coding	C	Runs well	90.9 tok/s	2131 ms	222K
Agentic Coding	C	Runs well	90.9 tok/s	3100 ms	222K
Reasoning	C	Runs well	90.9 tok/s	2518 ms	222K
RAG	C	Runs well	90.9 tok/s	3874 ms	222K

Inference speed

Qwen3.5 122B A10B inference speed — tokens per second by GPU & Mac

Estimated decode speed (tokens/sec) for Qwen3.5 122B A10B at Q3_K_M across popular GPUs and Apple Silicon, including multi-GPU rigs, using the fastest local runtime per device. Fastest is MacBook Pro M4 Max 128GB at ~9 tok/s. Speed is memory-bandwidth bound, so cards that fit the whole model in VRAM run far faster than ones that offload to system RAM.

GPU / Mac	Memory	Quant	Speed (tok/s)	Fits?
MacBook Pro M4 Max 128GB	128 GB	Q3_K_M	9.3	Offloads
Mac Studio M3 Ultra 256GB	256 GB	Q3_K_M	8.7	Fits
Mac Studio M2 Ultra 128GB	128 GB	Q3_K_M	7.2	Offloads
Mac Studio M1 Ultra 128GB	128 GB	Q3_K_M	6.8	Offloads
2× RX 7900 XTX 24GB	48 GB	Q3_K_M	4.7	Too big
MacBook Pro M4 Max 64GB	64 GB	Q3_K_M	4.5	Too big
RTX 5090 32GB	32 GB	Q3_K_M	2.8	Too big
MacBook Pro M4 Pro 48GB	48 GB	Q3_K_M	2.6	Too big
2× RTX 4090 24GB	48 GB	Q3_K_M	2.5	Too big
2× RTX 3090 24GB	48 GB	Q3_K_M	2.3	Too big
RTX 4090 24GB	24 GB	Q3_K_M	2.0	Too big
RTX 4080 Super 16GB	16 GB	Q3_K_M	2.0	Too big
RTX 3090 24GB	24 GB	Q3_K_M	2.0	Too big
RTX 4070 12GB	12 GB	Q3_K_M	2.0	Too big
RTX 3060 12GB	12 GB	Q3_K_M	2.0	Too big
RTX 4060 8GB	8 GB	Q3_K_M	2.0	Too big
RX 7900 XTX 24GB	24 GB	Q3_K_M	2.0	Too big
MacBook Pro M3 Max 64GB	64 GB	Q3_K_M	2.0	Too big
MacBook Pro M1 Max 64GB	64 GB	Q3_K_M	2.0	Too big
4× RTX 3060 12GB	48 GB	Q3_K_M	2.0	Too big

Estimates for single-stream decoding at Q3_K_M; real tokens/sec varies with prompt length, context, batch size, and runtime build. Prompt processing (prefill) is faster than the decode figures shown here.

Quantization options

How Qwen3.5 122B A10B (122B params) fits at each quantization level on AMD Instinct MI350X 288GB (288.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	47.6 GB	Low	D39
Q3_K_S	3	59.8 GB	Low	C40
NVFP4	4	68.3 GB	Medium	C41
Q4_K_M	4	74.4 GB	Medium	C41
Q5_K_M	5	87.8 GB	High	C42
Q6_K	6	100.0 GB	High	C43
Q8_0	8	130.5 GB	Very High	C46
F16Best for your GPU	16	250.1 GB	Maximum	C48

Get started

Copy-paste commands to run Qwen3.5 122B A10B on your machine.

Run

docker run --rm -it ghcr.io/ggerganov/llama.cpp:full \
  --hf-repo "unsloth/Qwen3.5-122B-A10B-GGUF" \
  --hf-file "Qwen3.5-122B-A10B-GGUF-Q3_K_M.gguf" \
  -c 4096 -ngl 99

Frequently asked questions

Can AMD Instinct MI350X 288GB run Qwen3.5 122B A10B?

Yes, AMD Instinct MI350X 288GB can run Qwen3.5 122B A10B with a C grade (Runs well). Expected decode speed: 90.9 tok/s.

How much VRAM does Qwen3.5 122B A10B need?

Qwen3.5 122B A10B (122B parameters) requires approximately 103.8 GB of memory with Q3_K_M quantization.

What is the best quantization for Qwen3.5 122B A10B?

The recommended quantization for Qwen3.5 122B A10B is Q3_K_M, which balances quality and memory efficiency.

What speed will Qwen3.5 122B A10B run at on AMD Instinct MI350X 288GB?

On AMD Instinct MI350X 288GB, Qwen3.5 122B A10B achieves approximately 90.9 tokens per second decode speed with a time-to-first-token of 2131ms using Q3_K_M quantization.

Can AMD Instinct MI350X 288GB run Qwen3.5 122B A10B for coding?

For coding workloads, Qwen3.5 122B A10B on AMD Instinct MI350X 288GB receives a C grade with 90.9 tok/s and 222K context.

What context window can Qwen3.5 122B A10B use on AMD Instinct MI350X 288GB?

On AMD Instinct MI350X 288GB, Qwen3.5 122B A10B can safely use up to 222K tokens of context. The model's official context limit is —, but available memory constrains the safe maximum.

See all results for AMD Instinct MI350X 288GB See all hardware for Qwen3.5 122B A10B

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