Can Llama 3.3 70B Instruct run on AMD Instinct MI300X 192GB?

YES — Runs Great

C50Usable

Estimated from fit model

Llama 3.3 70B Instruct needs ~71.0 GB VRAM. AMD Instinct MI300X 192GB has 192.0 GB. With Q4_K_M quantization, expect ~97 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 71.0 GB, 96.8 tok/s, Runs well

71.0 GB required192.0 GB available

37% VRAM used

Fit status

Runs well

Decode

96.8 tok/s

TTFT

2000 ms

Safe context

252K

Memory

71.0 GB / 192.0 GB

Memory breakdown

Weights42.7 GB

KV Cache8.2 GB

Runtime0.9 GB

Headroom19.2 GB

See how fast it feels

See how fast it feelsLlama 3.3 70B Instruct on AMD Instinct MI300X 192GB
1st promptCold start — includes initialization
>What is local AI inference?
Local AI inference means running an AI language model directly on your own hardware — your laptop, desktop, or server — instead of sending requests to a remote cloud API.

When you run inference locally the model weights are loaded into your GPU or unified memory. Each token you generate requires reading those weights from memory, so memory bandwidth is the main bottleneck for decode speed.

Key benefits of running locally:
  - Full privacy: your prompts never leave your machine
  - No per-token cost or rate limits
  - Works offline once the model is downloaded
  - Latency depends only on your hardware
2nd promptWarm — model ready, no init overhead
>How much VRAM do I need?
It depends on the model size and quantization level. A rough rule of thumb:

  Model size     Q4 (4-bit)    Q8 (8-bit)    FP16
  7B params      ~4.3 GB       ~7.5 GB       ~14 GB
  13B params     ~7.9 GB       ~13.9 GB      ~26 GB
  70B params     ~42.7 GB      ~74.9 GB      ~140 GB

Most people use 4-bit quantization (Q4_K_M) which gives 90-95% of full quality at a fraction of the memory. A 24 GB GPU can comfortably run most 7B-13B models.
Estimated: 96.8 tok/s decode · 2.0s TTFT (warm) · 242 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	C	Runs well	96.8 tok/s	1091 ms	252K
Coding	C	Runs well	96.8 tok/s	2000 ms	252K
Agentic Coding	C	Runs well	96.8 tok/s	2909 ms	252K
Reasoning	C	Runs well	96.8 tok/s	2363 ms	252K
RAG	C	Runs well	96.8 tok/s	3636 ms	252K

Quantization options

How Llama 3.3 70B Instruct (70B params) fits at each quantization level on AMD Instinct MI300X 192GB (192.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	27.3 GB	Low	D39
Q3_K_S	3	34.3 GB	Low	D39
NVFP4	4	39.2 GB	Medium	C40
Q4_K_M	4	42.7 GB	Medium	C40
Q5_K_M	5	50.4 GB	High	C41
Q6_K	6	57.4 GB	High	C42
Q8_0	8	74.9 GB	Very High	C44
F16Best for your GPU	16	143.5 GB	Maximum	C48

Get started

Copy-paste commands to run Llama 3.3 70B Instruct on your machine.

Run

lms load hf-maziyarpanahi--llama-3-3-70b-instruct-gguf && lms server start

Frequently asked questions

Can AMD Instinct MI300X 192GB run Llama 3.3 70B Instruct?

Yes, AMD Instinct MI300X 192GB can run Llama 3.3 70B Instruct with a C grade (Runs well). Expected decode speed: 96.8 tok/s.

How much VRAM does Llama 3.3 70B Instruct need?

Llama 3.3 70B Instruct (70B parameters) requires approximately 71.0 GB of memory with Q4_K_M quantization.

What is the best quantization for Llama 3.3 70B Instruct?

The recommended quantization for Llama 3.3 70B Instruct is Q4_K_M, which balances quality and memory efficiency.

What speed will Llama 3.3 70B Instruct run at on AMD Instinct MI300X 192GB?

On AMD Instinct MI300X 192GB, Llama 3.3 70B Instruct achieves approximately 96.8 tokens per second decode speed with a time-to-first-token of 2000ms using Q4_K_M quantization.

Can AMD Instinct MI300X 192GB run Llama 3.3 70B Instruct for coding?

For coding workloads, Llama 3.3 70B Instruct on AMD Instinct MI300X 192GB receives a C grade with 96.8 tok/s and 252K context.

What context window can Llama 3.3 70B Instruct use on AMD Instinct MI300X 192GB?

On AMD Instinct MI300X 192GB, Llama 3.3 70B Instruct can safely use up to 252K tokens of context. The model's official context limit is —, but available memory constrains the safe maximum.

See all results for AMD Instinct MI300X 192GB See all hardware for Llama 3.3 70B Instruct

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