Can Falcon 40B Instruct run on AMD Instinct MI350X 288GB?

YES — Runs Great

B67Good

Estimated from fit model

Falcon 40B Instruct needs ~60.6 GB VRAM. AMD Instinct MI350X 288GB has 288.0 GB. With Q5_K_M quantization, expect ~225 tok/s.

Runtime: OllamaCapacity: RoomyBandwidth: HighStack: BasicBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q5_K_M (High quality) — 60.6 GB, 224.9 tok/s, Runs well

60.6 GB required288.0 GB available

21% VRAM used

Fit status

Runs well

Decode

224.9 tok/s

TTFT

861 ms

Safe context

Memory

60.6 GB / 288.0 GB

Memory breakdown

Weights28.8 GB

KV Cache1.8 GB

Runtime1.2 GB

Headroom28.8 GB

See how fast it feels

See how fast it feelsFalcon 40B Instruct on AMD Instinct MI350X 288GB
1st promptCold start — includes initialization
>Solve: If a train travels at 60 mph for 2.5 hours, how far does it go?
Let me work through this step by step.

Given information:
  - Speed = 60 mph (miles per hour)
  - Time  = 2.5 hours

Formula: Distance = Speed x Time

Calculation:
  Distance = 60 mph x 2.5 h
           = 150 miles

The train travels 150 miles.

Double-check: at 60 mph the train covers 60 miles each hour. In half an hour it covers 30 miles. So in 2.5 hours: 60 + 60 + 30 = 150 miles. Confirmed.
2nd promptWarm — model ready, no init overhead
>What if the train stops for 20 minutes halfway?
The stop doesn't change the total distance covered while moving, but it affects total trip time.

Breakdown:
  - First half: 1.25 hours at 60 mph = 75 miles
  - Stop: 20 minutes (no distance)
  - Second half: 1.25 hours at 60 mph = 75 miles

Total distance: 150 miles (same)
Total time: 2.5 h + 0.33 h = 2.83 hours
Average speed: 150 / 2.83 = 53 mph

The distance stays the same but average speed drops to 53 mph because of the stop.
Estimated: 224.9 tok/s decode · 861ms TTFT (warm) · 562 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	B	Runs well	224.9 tok/s	469 ms	8K
Coding	B	Runs well	224.9 tok/s	861 ms	8K
Agentic Coding	B	Runs well	224.9 tok/s	1252 ms	8K
Reasoning	B	Runs well	224.9 tok/s	1017 ms	8K
RAG	B	Runs well	224.9 tok/s	1565 ms	8K

Quantization options

How Falcon 40B Instruct (40B params) fits at each quantization level on AMD Instinct MI350X 288GB (288.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	15.6 GB	Low	B57
Q3_K_S	3	19.6 GB	Low	B57
NVFP4	4	22.4 GB	Medium	B58
Q4_K_M	4	24.4 GB	Medium	B58
Q5_K_M	5	28.8 GB	High	B58
Q6_K	6	32.8 GB	High	B58
Q8_0	8	42.8 GB	Very High	B59
F16Best for your GPU	16	82.0 GB	Maximum	B62

Get started

Copy-paste commands to run Falcon 40B Instruct on your machine.

Run

docker run --rm -it ghcr.io/ggerganov/llama.cpp:full \
  --hf-repo "tiiuae/falcon-40b-instruct" \
  --hf-file "falcon-40b-instruct-Q5_K_M.gguf" \
  -c 4096 -ngl 99

Frequently asked questions

Can AMD Instinct MI350X 288GB run Falcon 40B Instruct?

Yes, AMD Instinct MI350X 288GB can run Falcon 40B Instruct with a B grade (Runs well). Expected decode speed: 224.9 tok/s.

How much VRAM does Falcon 40B Instruct need?

Falcon 40B Instruct (40B parameters) requires approximately 60.6 GB of memory with Q5_K_M quantization.

What is the best quantization for Falcon 40B Instruct?

The recommended quantization for Falcon 40B Instruct is Q5_K_M, which balances quality and memory efficiency.

What speed will Falcon 40B Instruct run at on AMD Instinct MI350X 288GB?

On AMD Instinct MI350X 288GB, Falcon 40B Instruct achieves approximately 224.9 tokens per second decode speed with a time-to-first-token of 861ms using Q5_K_M quantization.

Can AMD Instinct MI350X 288GB run Falcon 40B Instruct for coding?

For coding workloads, Falcon 40B Instruct on AMD Instinct MI350X 288GB receives a B grade with 224.9 tok/s and 8K context.

What context window can Falcon 40B Instruct use on AMD Instinct MI350X 288GB?

On AMD Instinct MI350X 288GB, Falcon 40B Instruct can safely use up to 8K tokens of context. The model's official context limit is 8K, but available memory constrains the safe maximum.

See all results for AMD Instinct MI350X 288GB See all hardware for Falcon 40B Instruct

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