Can Wan Video 2.1 14B run on AMD Instinct MI350X 288GB?
YES — Runs Great
S90Excellent
Wan Video 2.1 14B needs ~56.2 GB VRAM. AMD Instinct MI350X 288GB has 288.0 GB.
56.2 GB required288.0 GB available
20% VRAM used
Parameters
14B
Precision
FP16
Max Resolution
720×1280
VRAM
56.2 GB / 288.0 GB
Gen Time
300ms/frame
Performance by workload
| Workload | Grade | Fit | VRAM | Per Frame |
|---|---|---|---|---|
| Short Clip | S | Runs natively | 56.2 GB | 300ms |
| Long Video | S | Runs natively | 79.4 GB | 400ms |
Video scenario compatibility
How Wan Video 2.1 14B (14B params) performs at each scenario on AMD Instinct MI350X 288GB (288.0 GB usable).
FP16 (full precision)
| Scenario | VRAM | AMD Instinct MI350X 288GB |
|---|---|---|
| 512×512 · 25 frames | 54.1 GB | S |
| 768×512 · 25 frames | 56.2 GB | S |
| 768×512 · 100 frames | 62.5 GB | S |
| 1280×720 · 25 frames | 64.6 GB | S |
FP8 (quantized — ~40% less VRAM)
| Scenario | VRAM | AMD Instinct MI350X 288GB |
|---|---|---|
| 512×512 · 25 frames | 29.5 GB | S |
| 768×512 · 25 frames | 31.6 GB | S |
| 768×512 · 100 frames | 37.9 GB | S |
| 1280×720 · 25 frames | 40.1 GB | S |
Memory breakdown
Required: 56.2 GBAvailable: 288.0 GB
Weights28.0 GB
VAE0.2 GB
Text Encoder18.8 GB
Activations6.0 GB
Overhead0.5 GB
Frequently asked questions
Can AMD Instinct MI350X 288GB run Wan Video 2.1 14B?
Yes, AMD Instinct MI350X 288GB can run Wan Video 2.1 14B for video generation. Runs natively.
How much VRAM does Wan Video 2.1 14B need?
Wan Video 2.1 14B (14B parameters) requires approximately 56.2 GB at FP16. AMD Instinct MI350X 288GB provides 288.0 GB.
What resolution and duration can Wan Video 2.1 14B produce on AMD Instinct MI350X 288GB?
On AMD Instinct MI350X 288GB, Wan Video 2.1 14B can generate video at up to 720x1280. Generation time is approximately 0.3 seconds per frame.
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