Can Mixtral 8x22B run on NVIDIA H200 PCIe 141GB?

YES — Runs Great

A70Great

Estimated from fit model

Mixtral 8x22B needs ~104.4 GB VRAM. NVIDIA H200 PCIe 141GB has 141.0 GB. With Q4_K_M quantization, expect ~97 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 104.4 GB, 97.4 tok/s, Runs well

104.4 GB required141.0 GB available

74% VRAM used

Fit status

Runs well

Decode

97.4 tok/s

TTFT

1987 ms

Safe context

66K

Memory

104.4 GB / 141.0 GB

Memory breakdown

Weights86.0 GB

KV Cache3.4 GB

Runtime0.9 GB

Headroom14.1 GB

See how fast it feels

See how fast it feelsMixtral 8x22B on NVIDIA H200 PCIe 141GB
1st promptCold start — includes initialization
>Solve: If a train travels at 60 mph for 2.5 hours, how far does it go?
Let me work through this step by step.

Given information:
  - Speed = 60 mph (miles per hour)
  - Time  = 2.5 hours

Formula: Distance = Speed x Time

Calculation:
  Distance = 60 mph x 2.5 h
           = 150 miles

The train travels 150 miles.

Double-check: at 60 mph the train covers 60 miles each hour. In half an hour it covers 30 miles. So in 2.5 hours: 60 + 60 + 30 = 150 miles. Confirmed.
2nd promptWarm — model ready, no init overhead
>What if the train stops for 20 minutes halfway?
The stop doesn't change the total distance covered while moving, but it affects total trip time.

Breakdown:
  - First half: 1.25 hours at 60 mph = 75 miles
  - Stop: 20 minutes (no distance)
  - Second half: 1.25 hours at 60 mph = 75 miles

Total distance: 150 miles (same)
Total time: 2.5 h + 0.33 h = 2.83 hours
Average speed: 150 / 2.83 = 53 mph

The distance stays the same but average speed drops to 53 mph because of the stop.
Estimated: 97.4 tok/s decode · 2.0s TTFT (warm) · 244 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	A	Runs well	97.4 tok/s	1084 ms	66K
Coding	A	Runs well	97.4 tok/s	1987 ms	66K
Agentic Coding	A	Runs well	97.4 tok/s	2890 ms	66K
Reasoning	A	Runs well	97.4 tok/s	2349 ms	66K
RAG	A	Runs well	97.4 tok/s	3613 ms	66K

Quantization options

How Mixtral 8x22B (141B params) fits at each quantization level on NVIDIA H200 PCIe 141GB (141.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	55.0 GB	Low	B58
Q3_K_S	3	69.1 GB	Low	B60
NVFP4	4	79.0 GB	Medium	B61
Q4_K_M	4	86.0 GB	Medium	B61
Q5_K_M	5	101.5 GB	High	B61
Q6_KBest for your GPU	6	115.6 GB	High	B61
Q8_0	8	150.9 GB	Very High	F0
F16	16	289.0 GB	Maximum	F0

Get started

Copy-paste commands to run Mixtral 8x22B on your machine.

Run

ollama run mixtral:8x22b

Your hardware

More models your NVIDIA H200 PCIe 141GB can run

Model	Params	Grade	Decode	Capabilities
Qwen 3 235B A22B	235B	A	47.7 tok/s
MiniMax M2.7	230B	A	55.8 tok/s

Frequently asked questions

Can NVIDIA H200 PCIe 141GB run Mixtral 8x22B?

Yes, NVIDIA H200 PCIe 141GB can run Mixtral 8x22B with a A grade (Runs well). Expected decode speed: 97.4 tok/s.

How much VRAM does Mixtral 8x22B need?

Mixtral 8x22B (141B parameters) requires approximately 104.4 GB of memory with Q4_K_M quantization.

What is the best quantization for Mixtral 8x22B?

The recommended quantization for Mixtral 8x22B is Q4_K_M, which balances quality and memory efficiency.

What speed will Mixtral 8x22B run at on NVIDIA H200 PCIe 141GB?

On NVIDIA H200 PCIe 141GB, Mixtral 8x22B achieves approximately 97.4 tokens per second decode speed with a time-to-first-token of 1987ms using Q4_K_M quantization.

Can NVIDIA H200 PCIe 141GB run Mixtral 8x22B for coding?

For coding workloads, Mixtral 8x22B on NVIDIA H200 PCIe 141GB receives a A grade with 97.4 tok/s and 66K context.

What context window can Mixtral 8x22B use on NVIDIA H200 PCIe 141GB?

On NVIDIA H200 PCIe 141GB, Mixtral 8x22B can safely use up to 66K tokens of context. The model's official context limit is 66K, but available memory constrains the safe maximum.

See all results for NVIDIA H200 PCIe 141GB See all hardware for Mixtral 8x22B

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