Will It Run AI

Can Hermes 4.3 36B run on AMD Instinct MI250X 128GB?

YES — Runs Great

C48Usable
Estimated from fit model

Hermes 4.3 36B needs ~39.9 GB VRAM. AMD Instinct MI250X 128GB has 128.0 GB. With Q4_K_M quantization, expect ~114 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced
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Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 39.9 GB, 113.7 tok/s, Runs well
39.9 GB required128.0 GB available
31% VRAM used

Fit status

Runs well

Decode

113.7 tok/s

TTFT

1703 ms

Safe context

350K

Memory

39.9 GB / 128.0 GB

Memory breakdown

Weights22.0 GB
KV Cache4.2 GB
Runtime0.9 GB
Headroom12.8 GB

See how fast it feels

See how fast it feelsHermes 4.3 36B on AMD Instinct MI250X 128GB
1st promptCold start — includes initialization
>Solve: If a train travels at 60 mph for 2.5 hours, how far does it go?
Let me work through this step by step. Given information: - Speed = 60 mph (miles per hour) - Time = 2.5 hours Formula: Distance = Speed x Time Calculation: Distance = 60 mph x 2.5 h = 150 miles The train travels 150 miles. Double-check: at 60 mph the train covers 60 miles each hour. In half an hour it covers 30 miles. So in 2.5 hours: 60 + 60 + 30 = 150 miles. Confirmed.
2nd promptWarm — model ready, no init overhead
>What if the train stops for 20 minutes halfway?
The stop doesn't change the total distance covered while moving, but it affects total trip time. Breakdown: - First half: 1.25 hours at 60 mph = 75 miles - Stop: 20 minutes (no distance) - Second half: 1.25 hours at 60 mph = 75 miles Total distance: 150 miles (same) Total time: 2.5 h + 0.33 h = 2.83 hours Average speed: 150 / 2.83 = 53 mph The distance stays the same but average speed drops to 53 mph because of the stop.
Estimated: 113.7 tok/s decode · 1.7s TTFT (warm) · 284 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

WorkloadGradeFitDecodeTTFTContext
ChatCRuns well113.7 tok/s929 ms350K
CodingCRuns well113.7 tok/s1703 ms350K
Agentic CodingCRuns well113.7 tok/s2478 ms350K
ReasoningCRuns well113.7 tok/s2013 ms350K
RAGCRuns well113.7 tok/s3097 ms350K

Quantization options

How Hermes 4.3 36B (36B params) fits at each quantization level on AMD Instinct MI250X 128GB (128.0 GB usable).

QuantBitsVRAMQualityFit
Q2_K
2
14.0 GB
LowD38
Q3_K_S
3
17.6 GB
LowD39
NVFP4
4
20.2 GB
MediumD39
Q4_K_M
4
22.0 GB
MediumD39
Q5_K_M
5
25.9 GB
HighD40
Q6_K
6
29.5 GB
HighC40
Q8_0
8
38.5 GB
Very HighC42
F16Best for your GPU
16
73.8 GB
MaximumC48

Get started

Copy-paste commands to run Hermes 4.3 36B on your machine.

Run

lms load hf-nousresearch--hermes-4-3-36b-gguf && lms server start

Frequently asked questions

Can AMD Instinct MI250X 128GB run Hermes 4.3 36B?

Yes, AMD Instinct MI250X 128GB can run Hermes 4.3 36B with a C grade (Runs well). Expected decode speed: 113.7 tok/s.

How much VRAM does Hermes 4.3 36B need?

Hermes 4.3 36B (36B parameters) requires approximately 39.9 GB of memory with Q4_K_M quantization.

What is the best quantization for Hermes 4.3 36B?

The recommended quantization for Hermes 4.3 36B is Q4_K_M, which balances quality and memory efficiency.

What speed will Hermes 4.3 36B run at on AMD Instinct MI250X 128GB?

On AMD Instinct MI250X 128GB, Hermes 4.3 36B achieves approximately 113.7 tokens per second decode speed with a time-to-first-token of 1703ms using Q4_K_M quantization.

Can AMD Instinct MI250X 128GB run Hermes 4.3 36B for coding?

For coding workloads, Hermes 4.3 36B on AMD Instinct MI250X 128GB receives a C grade with 113.7 tok/s and 350K context.

What context window can Hermes 4.3 36B use on AMD Instinct MI250X 128GB?

On AMD Instinct MI250X 128GB, Hermes 4.3 36B can safely use up to 350K tokens of context. The model's official context limit is —, but available memory constrains the safe maximum.

See all results for AMD Instinct MI250X 128GBSee all hardware for Hermes 4.3 36B
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