Can Qwen3-Coder 480B A35B Instruct run on AMD Instinct MI250X 128GB?

Q: What should I upgrade first if Qwen3-Coder 480B A35B Instruct feels slow on AMD Instinct MI250X 128GB?

Add more VRAM headroom. The first useful upgrade is more dedicated VRAM so you can fit the model without shrinking context or dropping to a much lower quant.

NO — Won't Fit

F0Won't run

Estimated from fit model

Qwen3-Coder 480B A35B Instruct needs ~309.4 GB but AMD Instinct MI250X 128GB only has 128.0 GB. Try a smaller quantization or lighter model.

Runtime: llama.cppCapacity: No fitBandwidth: HighStack: StandardBottleneck: Memory capacity

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 309.4 GB, exceeds 128.0 GB available

309.4 GB required128.0 GB available

242% VRAM needed

181.4 GB over capacity — needs offload or smaller quantization

Fit status

Too heavy

Decode

3.9 tok/s

TTFT

49603 ms

Safe context

Memory

309.4 GB / 128.0 GB

Offload

60%

Memory breakdown

Weights292.8 GB

KV Cache2.9 GB

Runtime0.9 GB

Headroom12.8 GB

See how fast it feels

With memory offload — actual speed may be lower

See how fast it feelsQwen3-Coder 480B A35B Instruct on AMD Instinct MI250X 128GB
1st promptCold start — includes initialization
>Write a Python function to sort a list
Here's a Python function that sorts a list using quicksort:

def quicksort(arr):
    if len(arr) <= 1:
        return arr
    pivot = arr[len(arr) // 2]
    left   = [x for x in arr if x < pivot]
    middle = [x for x in arr if x == pivot]
    right  = [x for x in arr if x > pivot]
    return quicksort(left) + middle + quicksort(right)

# Example usage
numbers = [3, 6, 8, 10, 1, 2, 1]
print(quicksort(numbers))  # [1, 1, 2, 3, 6, 8, 10]

The algorithm picks a pivot, partitions the list into smaller, equal, and larger elements, then recursively sorts each partition and concatenates the results.
2nd promptWarm — model ready, no init overhead
>Now add type hints and a docstring
def quicksort(arr: list[int]) -> list[int]:
    """Sort a list using the quicksort algorithm.

    Args:
        arr: List of integers to sort.

    Returns:
        A new sorted list.
    """
    if len(arr) <= 1:
        return arr
    pivot = arr[len(arr) // 2]
    left   = [x for x in arr if x < pivot]
    middle = [x for x in arr if x == pivot]
    right  = [x for x in arr if x > pivot]
    return quicksort(left) + middle + quicksort(right)

Added type hints for the input and return type, plus a Google-style docstring.
Estimated: 3.9 tok/s decode · 49.6s TTFT (warm) · 10 tok/s prefill

What limits this setup

Usable VRAM is the main blocker for this model.

Not enough usable memory

The model needs 309.4 GB, but this setup only exposes 128.0 GB of usable VRAM.

Best improvement path

Add more VRAM headroom

The first useful upgrade is more dedicated VRAM so you can fit the model without shrinking context or dropping to a much lower quant.

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	F	Too heavy	3.9 tok/s	27056 ms	4K
Coding	F	Too heavy	3.9 tok/s	49603 ms	4K
Agentic Coding	F	Too heavy	3.9 tok/s	72150 ms	4K
Reasoning	F	Too heavy	3.9 tok/s	58622 ms	4K
RAG	F	Too heavy	3.9 tok/s	90188 ms	4K

Quantization options

How Qwen3-Coder 480B A35B Instruct (480B params) fits at each quantization level on AMD Instinct MI250X 128GB (128.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	187.2 GB	Low	F0
Q3_K_S	3	235.2 GB	Low	F0
NVFP4	4

Upgrade options

Hardware that runs Qwen3-Coder 480B A35B Instruct well

AMD Instinct MI350X 288GBBest value

288 GB VRAM (+160)8000 GB/s (+4800)

Makes the model fit on the accelerator instead of staying completely out of reach.35.3 tok/s decode

Makes the model fit on the accelerator instead of staying completely out of reach.

Raises estimated decode speed by about 805%.

~$8,000 MSRP

Frequently asked questions

Can AMD Instinct MI250X 128GB run Qwen3-Coder 480B A35B Instruct?

No, Qwen3-Coder 480B A35B Instruct requires more memory than AMD Instinct MI250X 128GB provides.

How much VRAM does Qwen3-Coder 480B A35B Instruct need?

Qwen3-Coder 480B A35B Instruct (480B parameters) requires approximately 309.4 GB of memory with Q4_K_M quantization.

What is the best quantization for Qwen3-Coder 480B A35B Instruct?

The recommended quantization for Qwen3-Coder 480B A35B Instruct is Q4_K_M, which balances quality and memory efficiency.

What speed will Qwen3-Coder 480B A35B Instruct run at on AMD Instinct MI250X 128GB?

On AMD Instinct MI250X 128GB, Qwen3-Coder 480B A35B Instruct achieves approximately 3.9 tokens per second decode speed with a time-to-first-token of 49603ms using Q4_K_M quantization.

Can AMD Instinct MI250X 128GB run Qwen3-Coder 480B A35B Instruct for coding?

For coding workloads, Qwen3-Coder 480B A35B Instruct on AMD Instinct MI250X 128GB receives a F grade with 3.9 tok/s and 4K context.

What context window can Qwen3-Coder 480B A35B Instruct use on AMD Instinct MI250X 128GB?

On AMD Instinct MI250X 128GB, Qwen3-Coder 480B A35B Instruct can safely use up to 4K tokens of context. The model's official context limit is 256K, but available memory constrains the safe maximum.

See all results for AMD Instinct MI250X 128GB See all hardware for Qwen3-Coder 480B A35B Instruct

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