Qwen 2.5 72B needs ~39.0 GB VRAM. MacBook Pro M4 Pro 48GB has 34.6 GB. With Q2_K quantization, expect ~10 tok/s.
Operating mode
Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.
Current mode
Balanced
Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.
Select quantization to explore
20.3 GB over capacity — needs offload or smaller quantization
Fit status
Too heavy
Decode
5.1 tok/s
TTFT
37689 ms
Safe context
4K
Memory
54.9 GB / 34.6 GB
Offload
40%
It fits through host-memory offload, and offload is the main reason performance drops.
CPU or host-memory offload is active
About 10% of the working set spills out of accelerator memory, which usually hurts latency and sustained decode throughput.
Very little memory headroom
You can run the model, but there is not much room left for longer context, bigger batches, extra apps, or future model updates.
Shared-memory contention still exists
The OS, browser, and inference runtime all compete for the same physical memory pool, so real-world headroom is less forgiving than raw capacity suggests.
Remove offload with more accelerator memory
Prioritize a GPU or unified-memory tier that fits the whole model natively. Removing offload usually helps more than small compute gains.
Buy headroom, not only minimum fit
A slightly larger memory tier gives you safer context growth and makes the recommendation more future-proof.
Increase host RAM if you keep offloading
This setup may need roughly 3.2 GB of extra host RAM just for the offloaded portion, before OS and other tools.
| Workload | Grade | Fit | Decode | TTFT | Context |
|---|---|---|---|---|---|
| Chat | F | Too heavy | 5.4 tok/s | 19531 ms | 4K |
| Coding | F | Too heavy | 5.1 tok/s | 37689 ms | 4K |
| Agentic Coding | F | Too heavy | 4.7 tok/s | 60266 ms | 4K |
| Reasoning | F | Too heavy | 5.1 tok/s | 44542 ms | 4K |
| RAG | F | Too heavy | 4.7 tok/s | 75332 ms | 4K |
How Qwen 2.5 72B (72B params) fits at each quantization level on MacBook Pro M4 Pro 48GB (34.6 GB usable).
| Quant | Bits | VRAM | Quality | Fit |
|---|---|---|---|---|
Q2_K | 2 | 28.1 GB | Low | F0 |
Q3_K_S | 3 | 35.3 GB | Low | F0 |
NVFP4 | 4 |
Copy-paste commands to run Qwen 2.5 72B on your machine.
Run
ollama run qwen2.5:72bUpgrade options
Makes the model fit on the accelerator instead of staying completely out of reach.
Removes host-memory offload, which is usually the single biggest latency and throughput win.
~$2,499 MSRP
Makes the model fit on the accelerator instead of staying completely out of reach.
Removes host-memory offload, which is usually the single biggest latency and throughput win.
~$2,499 MSRP
Makes the model fit on the accelerator instead of staying completely out of reach.
Removes host-memory offload, which is usually the single biggest latency and throughput win.
~$3,199 MSRP
NVIDIA H100 80GBBiggest leapMakes the model fit on the accelerator instead of staying completely out of reach.
Removes host-memory offload, which is usually the single biggest latency and throughput win.
~$40,000 MSRP
Yes, MacBook Pro M4 Pro 48GB can run Qwen 2.5 72B at Q2_K quantization (Very compromised (needs ~3.2 GB host RAM)). The recommended Q4_K_M requires 54.9 GB which exceeds available memory, but at Q2_K it needs only 39.0 GB. Expected decode speed: 10.2 tok/s.
Qwen 2.5 72B (72B parameters) requires approximately 54.9 GB at Q4_K_M quantization. On MacBook Pro M4 Pro 48GB, it fits at Q2_K using 39.0 GB.
The recommended quantization is Q4_K_M, but on MacBook Pro M4 Pro 48GB the best fitting quantization is Q2_K, which uses 39.0 GB.
On MacBook Pro M4 Pro 48GB, Qwen 2.5 72B achieves approximately 10.2 tokens per second decode speed with a time-to-first-token of 18888ms using Q2_K quantization.
For coding workloads, Qwen 2.5 72B on MacBook Pro M4 Pro 48GB receives a F grade with 5.1 tok/s and 4K context.
On MacBook Pro M4 Pro 48GB, Qwen 2.5 72B can safely use up to 4K tokens of context at Q2_K quantization. The model's official context limit is 131K, but available memory constrains the safe maximum.
Paste this snippet into any page to show a live fit card.
<iframe src="https://willitrunai.com/embed/qwen-2.5-72b-on-m4-pro-48gb" width="400" height="180" frameborder="0" style="border:none;border-radius:12px;overflow:hidden;" title="Will It Run AI — fit result"></iframe>
Preview:
| Medium |
| F0 |
Q4_K_M | 4 | 43.9 GB | Medium | F0 |
Q5_K_M | 5 | 51.8 GB | High | F0 |
Q6_K | 6 | 59.0 GB | High | F0 |
Q8_0 | 8 | 77.0 GB | Very High | F0 |
F16 | 16 | 147.6 GB | Maximum | F0 |
Remove offload with more accelerator memory. Prioritize a GPU or unified-memory tier that fits the whole model natively. Removing offload usually helps more than small compute gains.
Not always. MacBook Pro M4 Pro 48GB can often fit larger models thanks to unified memory, but a discrete GPU with dedicated high-bandwidth VRAM may still decode faster once the model fits. For this combination, the important distinction is capacity versus sustained throughput.