Qwen 2.5 72B needs ~63.5 GB VRAM. Mac Studio M2 Ultra 128GB has 92.2 GB. With Q4_K_M quantization, expect ~12 tok/s.
Operating mode
Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.
Current mode
Balanced
Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.
Select quantization to explore
Fit status
Runs well
Decode
11.5 tok/s
TTFT
16851 ms
Safe context
110K
Memory
63.5 GB / 92.2 GB
This setup is broadly balanced for this model.
Shared-memory contention still exists
The OS, browser, and inference runtime all compete for the same physical memory pool, so real-world headroom is less forgiving than raw capacity suggests.
| Workload | Grade | Fit | Decode | TTFT | Context |
|---|---|---|---|---|---|
| Chat | A | Runs well | 11.5 tok/s | 9191 ms | 110K |
| Coding | A | Runs well | 11.5 tok/s | 16851 ms | 110K |
| Agentic Coding | A | Runs well | 11.5 tok/s | 24510 ms | 110K |
| Reasoning | A | Runs well | 11.5 tok/s | 19915 ms | 110K |
| RAG | A | Runs well | 10.6 tok/s | 33319 ms | 110K |
How Qwen 2.5 72B (72B params) fits at each quantization level on Mac Studio M2 Ultra 128GB (92.2 GB usable).
| Quant | Bits | VRAM | Quality | Fit |
|---|---|---|---|---|
Q2_K | 2 | 28.1 GB | Low | A74 |
Q3_K_S | 3 | 35.3 GB | Low | A75 |
NVFP4 | 4 |
Copy-paste commands to run Qwen 2.5 72B on your machine.
Run
ollama run qwen2.5:72bYour hardware
| Model | Params | Grade | Decode | Capabilities |
|---|---|---|---|---|
 Devstral 2 123B Instruct | 123B | S | 6.3 tok/s | |
 Qwen 3.5 122B A10B | 122B | S |
Yes, Mac Studio M2 Ultra 128GB can run Qwen 2.5 72B with a A grade (Runs well). Expected decode speed: 11.5 tok/s.
Qwen 2.5 72B (72B parameters) requires approximately 63.5 GB of memory with Q4_K_M quantization.
The recommended quantization for Qwen 2.5 72B is Q4_K_M, which balances quality and memory efficiency.
On Mac Studio M2 Ultra 128GB, Qwen 2.5 72B achieves approximately 11.5 tokens per second decode speed with a time-to-first-token of 16851ms using Q4_K_M quantization.
For coding workloads, Qwen 2.5 72B on Mac Studio M2 Ultra 128GB receives a A grade with 11.5 tok/s and 110K context.
On Mac Studio M2 Ultra 128GB, Qwen 2.5 72B can safely use up to 110K tokens of context. The model's official context limit is 131K, but available memory constrains the safe maximum.
Paste this snippet into any page to show a live fit card.
<iframe src="https://willitrunai.com/embed/qwen-2.5-72b-on-m2-ultra-128gb" width="400" height="180" frameborder="0" style="border:none;border-radius:12px;overflow:hidden;" title="Will It Run AI — fit result"></iframe>
Preview:
40.3 GB |
| Medium |
| A77 |
Q4_K_M | 4 | 43.9 GB | Medium | A77 |
Q5_K_M | 5 | 51.8 GB | High | A79 |
Q6_K | 6 | 59.0 GB | High | A79 |
Q8_0Best for your GPU | 8 | 77.0 GB | Very High | A79 |
F16 | 16 | 147.6 GB | Maximum | F0 |
| 28.9 tok/s |
| Mistral Small 4 119B | 119B | S | 30.8 tok/s |
 GPT-OSS 120B | 117B | S | 7.1 tok/s |
 Command A 111B | 111B | S | 7.5 tok/s |
Not always. Mac Studio M2 Ultra 128GB can often fit larger models thanks to unified memory, but a discrete GPU with dedicated high-bandwidth VRAM may still decode faster once the model fits. For this combination, the important distinction is capacity versus sustained throughput.