Can Qwen 2.5 72B run on AMD Instinct MI325X 256GB?

YES — Runs Great

A79Great

Estimated from fit model

Qwen 2.5 72B needs ~75.3 GB VRAM. AMD Instinct MI325X 256GB has 256.0 GB. With Q4_K_M quantization, expect ~109 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 75.3 GB, 108.5 tok/s, Runs well

75.3 GB required256.0 GB available

29% VRAM used

Fit status

Runs well

Decode

108.5 tok/s

TTFT

1785 ms

Safe context

131K

Memory

75.3 GB / 256.0 GB

Memory breakdown

Weights43.9 GB

KV Cache4.9 GB

Runtime0.9 GB

Headroom25.6 GB

See how fast it feels

See how fast it feelsQwen 2.5 72B on AMD Instinct MI325X 256GB
1st promptCold start — includes initialization
>Solve: If a train travels at 60 mph for 2.5 hours, how far does it go?
Let me work through this step by step.

Given information:
  - Speed = 60 mph (miles per hour)
  - Time  = 2.5 hours

Formula: Distance = Speed x Time

Calculation:
  Distance = 60 mph x 2.5 h
           = 150 miles

The train travels 150 miles.

Double-check: at 60 mph the train covers 60 miles each hour. In half an hour it covers 30 miles. So in 2.5 hours: 60 + 60 + 30 = 150 miles. Confirmed.
2nd promptWarm — model ready, no init overhead
>What if the train stops for 20 minutes halfway?
The stop doesn't change the total distance covered while moving, but it affects total trip time.

Breakdown:
  - First half: 1.25 hours at 60 mph = 75 miles
  - Stop: 20 minutes (no distance)
  - Second half: 1.25 hours at 60 mph = 75 miles

Total distance: 150 miles (same)
Total time: 2.5 h + 0.33 h = 2.83 hours
Average speed: 150 / 2.83 = 53 mph

The distance stays the same but average speed drops to 53 mph because of the stop.
Estimated: 108.5 tok/s decode · 1.8s TTFT (warm) · 271 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	A	Runs well	108.5 tok/s	974 ms	131K
Coding	A	Runs well	108.5 tok/s	1785 ms	131K
Agentic Coding	A	Runs well	108.5 tok/s	2597 ms	131K
Reasoning	A	Runs well	108.5 tok/s	2110 ms	131K
RAG	A	Runs well	108.5 tok/s	3246 ms	131K

Quantization options

How Qwen 2.5 72B (72B params) fits at each quantization level on AMD Instinct MI325X 256GB (256.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	28.1 GB	Low	B69
Q3_K_S	3	35.3 GB	Low	B69
NVFP4	4

Get started

Copy-paste commands to run Qwen 2.5 72B on your machine.

Run

ollama run qwen2.5:72b

Your hardware

More models your AMD Instinct MI325X 256GB can run

Model	Params	Grade	Decode	Capabilities
Qwen 3.5 397B A17B	397B	A	39.2 tok/s
Devstral 2 123B Instruct	123B	S

Frequently asked questions

Can AMD Instinct MI325X 256GB run Qwen 2.5 72B?

Yes, AMD Instinct MI325X 256GB can run Qwen 2.5 72B with a A grade (Runs well). Expected decode speed: 108.5 tok/s.

How much VRAM does Qwen 2.5 72B need?

Qwen 2.5 72B (72B parameters) requires approximately 75.3 GB of memory with Q4_K_M quantization.

What is the best quantization for Qwen 2.5 72B?

The recommended quantization for Qwen 2.5 72B is Q4_K_M, which balances quality and memory efficiency.

What speed will Qwen 2.5 72B run at on AMD Instinct MI325X 256GB?

On AMD Instinct MI325X 256GB, Qwen 2.5 72B achieves approximately 108.5 tokens per second decode speed with a time-to-first-token of 1785ms using Q4_K_M quantization.

Can AMD Instinct MI325X 256GB run Qwen 2.5 72B for coding?

For coding workloads, Qwen 2.5 72B on AMD Instinct MI325X 256GB receives a A grade with 108.5 tok/s and 131K context.

What context window can Qwen 2.5 72B use on AMD Instinct MI325X 256GB?

On AMD Instinct MI325X 256GB, Qwen 2.5 72B can safely use up to 131K tokens of context. The model's official context limit is 131K, but available memory constrains the safe maximum.

See all results for AMD Instinct MI325X 256GB See all hardware for Qwen 2.5 72B

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