Can Pixtral Large 124B run on AMD Instinct MI300X 192GB?

YES — Runs Great

S91Excellent

Estimated from fit model

Pixtral Large 124B needs ~101.1 GB VRAM. AMD Instinct MI300X 192GB has 192.0 GB. With Q4_K_M quantization, expect ~59 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 101.1 GB, 59.4 tok/s, Runs well

101.1 GB required192.0 GB available

53% VRAM used

Fit status

Runs well

Decode

59.4 tok/s

TTFT

3257 ms

Safe context

131K

Memory

101.1 GB / 192.0 GB

Memory breakdown

Weights75.6 GB

KV Cache5.4 GB

Runtime0.9 GB

Headroom19.2 GB

See how fast it feels

See how fast it feelsPixtral Large 124B on AMD Instinct MI300X 192GB
1st promptCold start — includes initialization
>Solve: If a train travels at 60 mph for 2.5 hours, how far does it go?
Let me work through this step by step.

Given information:
  - Speed = 60 mph (miles per hour)
  - Time  = 2.5 hours

Formula: Distance = Speed x Time

Calculation:
  Distance = 60 mph x 2.5 h
           = 150 miles

The train travels 150 miles.

Double-check: at 60 mph the train covers 60 miles each hour. In half an hour it covers 30 miles. So in 2.5 hours: 60 + 60 + 30 = 150 miles. Confirmed.
2nd promptWarm — model ready, no init overhead
>What if the train stops for 20 minutes halfway?
The stop doesn't change the total distance covered while moving, but it affects total trip time.

Breakdown:
  - First half: 1.25 hours at 60 mph = 75 miles
  - Stop: 20 minutes (no distance)
  - Second half: 1.25 hours at 60 mph = 75 miles

Total distance: 150 miles (same)
Total time: 2.5 h + 0.33 h = 2.83 hours
Average speed: 150 / 2.83 = 53 mph

The distance stays the same but average speed drops to 53 mph because of the stop.
Estimated: 59.4 tok/s decode · 3.3s TTFT (warm) · 149 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	S	Runs well	59.4 tok/s	1777 ms	131K
Coding	S	Runs well	59.4 tok/s	3257 ms	131K
Agentic Coding	S	Runs well	59.4 tok/s	4738 ms	131K
Reasoning	S	Runs well	59.4 tok/s	3850 ms	131K
RAG	S	Runs well	59.4 tok/s	5922 ms	131K

Quantization options

How Pixtral Large 124B (124B params) fits at each quantization level on AMD Instinct MI300X 192GB (192.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	48.4 GB	Low	A81
Q3_K_S	3	60.8 GB	Low	A82
NVFP4	4	69.4 GB	Medium	A83
Q4_K_M	4	75.6 GB	Medium	A84
Q5_K_M	5	89.3 GB	High	S85
Q6_K	6	101.7 GB	High	S87
Q8_0Best for your GPU	8	132.7 GB	Very High	S87
F16	16	254.2 GB	Maximum	F0

Get started

Copy-paste commands to run Pixtral Large 124B on your machine.

Run

lms load Pixtral-Large-Instruct-2411 && lms server start

Your hardware

More models your AMD Instinct MI300X 192GB can run

Model	Params	Grade	Decode	Capabilities
DeepSeek V4 Flash	284B	S	89.1 tok/s

Frequently asked questions

Can AMD Instinct MI300X 192GB run Pixtral Large 124B?

Yes, AMD Instinct MI300X 192GB can run Pixtral Large 124B with a S grade (Runs well). Expected decode speed: 59.4 tok/s.

How much VRAM does Pixtral Large 124B need?

Pixtral Large 124B (124B parameters) requires approximately 101.1 GB of memory with Q4_K_M quantization.

What is the best quantization for Pixtral Large 124B?

The recommended quantization for Pixtral Large 124B is Q4_K_M, which balances quality and memory efficiency.

What speed will Pixtral Large 124B run at on AMD Instinct MI300X 192GB?

On AMD Instinct MI300X 192GB, Pixtral Large 124B achieves approximately 59.4 tokens per second decode speed with a time-to-first-token of 3257ms using Q4_K_M quantization.

Can AMD Instinct MI300X 192GB run Pixtral Large 124B for coding?

For coding workloads, Pixtral Large 124B on AMD Instinct MI300X 192GB receives a S grade with 59.4 tok/s and 131K context.

What context window can Pixtral Large 124B use on AMD Instinct MI300X 192GB?

On AMD Instinct MI300X 192GB, Pixtral Large 124B can safely use up to 131K tokens of context. The model's official context limit is 131K, but available memory constrains the safe maximum.

See all results for AMD Instinct MI300X 192GB See all hardware for Pixtral Large 124B

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<iframe src="https://willitrunai.com/embed/pixtral-large-124b-on-instinct-mi300x-192gb" width="400" height="180" frameborder="0" style="border:none;border-radius:12px;overflow:hidden;" title="Will It Run AI — fit result"></iframe>

Preview:

Workload

Grade

Fit

Decode

TTFT

Context

Chat

Runs well

59.4 tok/s

1777 ms

131K

Coding

Runs well

59.4 tok/s

3257 ms

131K

Agentic Coding

Runs well

59.4 tok/s

4738 ms

131K

Reasoning

Runs well

59.4 tok/s

3850 ms

131K

RAG

Runs well

59.4 tok/s

5922 ms

131K

Quantization options

How Pixtral Large 124B (124B params) fits at each quantization level on AMD Instinct MI300X 192GB (192.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	48.4 GB	Low	A81
Q3_K_S	3	60.8 GB	Low	A82
NVFP4	4	69.4 GB	Medium	A83
Q4_K_M	4	75.6 GB	Medium	A84
Q5_K_M	5	89.3 GB	High	S85
Q6_K	6	101.7 GB	High	S87
Q8_0Best for your GPU	8	132.7 GB	Very High	S87
F16	16	254.2 GB	Maximum	F0

Model

Params

Grade

Decode

Capabilities

DeepSeek V4 Flash

284B

89.1 tok/s

Frequently asked questions

Can AMD Instinct MI300X 192GB run Pixtral Large 124B?

Yes, AMD Instinct MI300X 192GB can run Pixtral Large 124B with a S grade (Runs well). Expected decode speed: 59.4 tok/s.

How much VRAM does Pixtral Large 124B need?

Pixtral Large 124B (124B parameters) requires approximately 101.1 GB of memory with Q4_K_M quantization.

What is the best quantization for Pixtral Large 124B?

The recommended quantization for Pixtral Large 124B is Q4_K_M, which balances quality and memory efficiency.

What speed will Pixtral Large 124B run at on AMD Instinct MI300X 192GB?

On AMD Instinct MI300X 192GB, Pixtral Large 124B achieves approximately 59.4 tokens per second decode speed with a time-to-first-token of 3257ms using Q4_K_M quantization.

Can AMD Instinct MI300X 192GB run Pixtral Large 124B for coding?

For coding workloads, Pixtral Large 124B on AMD Instinct MI300X 192GB receives a S grade with 59.4 tok/s and 131K context.

What context window can Pixtral Large 124B use on AMD Instinct MI300X 192GB?

On AMD Instinct MI300X 192GB, Pixtral Large 124B can safely use up to 131K tokens of context. The model's official context limit is 131K, but available memory constrains the safe maximum.