Mixtral 8x22B needs ~119.1 GB VRAM. AMD Instinct MI350X 288GB has 288.0 GB. With Q4_K_M quantization, expect ~141 tok/s.
Operating mode
Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.
Current mode
Balanced
Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.
Select quantization to explore
Fit status
Runs well
Decode
141.1 tok/s
TTFT
1372 ms
Safe context
66K
Memory
119.1 GB / 288.0 GB
This setup is broadly balanced for this model.
No major red flags
This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.
| Workload | Grade | Fit | Decode | TTFT | Context |
|---|---|---|---|---|---|
| Chat | B | Runs well | 141.1 tok/s | 748 ms | 66K |
| Coding | B | Runs well | 141.1 tok/s | 1372 ms | 66K |
| Agentic Coding | B | Runs well | 141.1 tok/s | 1996 ms | 66K |
| Reasoning | B | Runs well | 141.1 tok/s | 1621 ms | 66K |
| RAG | B | Runs well | 141.1 tok/s | 2495 ms | 66K |
How Mixtral 8x22B (141B params) fits at each quantization level on AMD Instinct MI350X 288GB (288.0 GB usable).
| Quant | Bits | VRAM | Quality | Fit |
|---|---|---|---|---|
Q2_K | 2 | 55.0 GB | Low | C53 |
Q3_K_S | 3 | 69.1 GB | Low | C54 |
NVFP4 | 4 | 79.0 GB | Medium | B55 |
Q4_K_M | 4 | 86.0 GB | Medium | B56 |
Q5_K_M | 5 | 101.5 GB | High | B57 |
Q6_K | 6 | 115.6 GB | High | B58 |
Q8_0Best for your GPU | 8 | 150.9 GB | Very High | B60 |
F16 | 16 | 289.0 GB | Maximum | F0 |
Copy-paste commands to run Mixtral 8x22B on your machine.
Run
ollama run mixtral:8x22bYes, AMD Instinct MI350X 288GB can run Mixtral 8x22B with a B grade (Runs well). Expected decode speed: 141.1 tok/s.
Mixtral 8x22B (141B parameters) requires approximately 119.1 GB of memory with Q4_K_M quantization.
The recommended quantization for Mixtral 8x22B is Q4_K_M, which balances quality and memory efficiency.
On AMD Instinct MI350X 288GB, Mixtral 8x22B achieves approximately 141.1 tokens per second decode speed with a time-to-first-token of 1372ms using Q4_K_M quantization.
For coding workloads, Mixtral 8x22B on AMD Instinct MI350X 288GB receives a B grade with 141.1 tok/s and 66K context.
On AMD Instinct MI350X 288GB, Mixtral 8x22B can safely use up to 66K tokens of context. The model's official context limit is 66K, but available memory constrains the safe maximum.
Paste this snippet into any page to show a live fit card.
<iframe src="https://willitrunai.com/embed/mixtral-8x22b-on-instinct-mi350x-288gb" width="400" height="180" frameborder="0" style="border:none;border-radius:12px;overflow:hidden;" title="Will It Run AI — fit result"></iframe>
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