Mixtral 8x22B needs ~104.4 GB VRAM. NVIDIA H200 PCIe 141GB has 141.0 GB. With Q4_K_M quantization, expect ~97 tok/s.
Operating mode
Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.
Current mode
Balanced
Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.
Select quantization to explore
Fit status
Runs well
Decode
97.4 tok/s
TTFT
1987 ms
Safe context
66K
Memory
104.4 GB / 141.0 GB
This setup is broadly balanced for this model.
No major red flags
This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.
| Workload | Grade | Fit | Decode | TTFT | Context |
|---|---|---|---|---|---|
| Chat | A | Runs well | 97.4 tok/s | 1084 ms | 66K |
| Coding | A | Runs well | 97.4 tok/s | 1987 ms | 66K |
| Agentic Coding | A | Runs well | 97.4 tok/s | 2890 ms | 66K |
| Reasoning | A | Runs well | 97.4 tok/s | 2349 ms | 66K |
| RAG | A | Runs well | 97.4 tok/s | 3613 ms | 66K |
How Mixtral 8x22B (141B params) fits at each quantization level on NVIDIA H200 PCIe 141GB (141.0 GB usable).
| Quant | Bits | VRAM | Quality | Fit |
|---|---|---|---|---|
Q2_K | 2 | 55.0 GB | Low | B58 |
Q3_K_S | 3 | 69.1 GB | Low | B60 |
NVFP4 | 4 | 79.0 GB | Medium | B61 |
Q4_K_M | 4 | 86.0 GB | Medium | B61 |
Q5_K_M | 5 | 101.5 GB | High | B61 |
Q6_KBest for your GPU | 6 | 115.6 GB | High | B61 |
Q8_0 | 8 | 150.9 GB | Very High | F0 |
F16 | 16 | 289.0 GB | Maximum | F0 |
Copy-paste commands to run Mixtral 8x22B on your machine.
Run
ollama run mixtral:8x22bYour hardware
| Model | Params | Grade | Decode | Capabilities |
|---|---|---|---|---|
 Qwen 3 235B A22B | 235B | A | 47.7 tok/s | |
| MiniMax M2.7 | 230B | A | 55.8 tok/s |
Yes, NVIDIA H200 PCIe 141GB can run Mixtral 8x22B with a A grade (Runs well). Expected decode speed: 97.4 tok/s.
Mixtral 8x22B (141B parameters) requires approximately 104.4 GB of memory with Q4_K_M quantization.
The recommended quantization for Mixtral 8x22B is Q4_K_M, which balances quality and memory efficiency.
On NVIDIA H200 PCIe 141GB, Mixtral 8x22B achieves approximately 97.4 tokens per second decode speed with a time-to-first-token of 1987ms using Q4_K_M quantization.
For coding workloads, Mixtral 8x22B on NVIDIA H200 PCIe 141GB receives a A grade with 97.4 tok/s and 66K context.
On NVIDIA H200 PCIe 141GB, Mixtral 8x22B can safely use up to 66K tokens of context. The model's official context limit is 66K, but available memory constrains the safe maximum.
Paste this snippet into any page to show a live fit card.
<iframe src="https://willitrunai.com/embed/mixtral-8x22b-on-h200-pcie-141gb" width="400" height="180" frameborder="0" style="border:none;border-radius:12px;overflow:hidden;" title="Will It Run AI — fit result"></iframe>
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