Can Mistral Large 3 run on AMD Instinct MI250 128GB?

Q: What should I upgrade first if Mistral Large 3 feels slow on AMD Instinct MI250 128GB?

Add more VRAM headroom. The first useful upgrade is more dedicated VRAM so you can fit the model without shrinking context or dropping to a much lower quant.

NO — Won't Fit

F0Won't run

Estimated from fit model

Mistral Large 3 needs ~432.3 GB but AMD Instinct MI250 128GB only has 128.0 GB. Try a smaller quantization or lighter model.

Runtime: vLLMCapacity: No fitBandwidth: HighStack: OptimizedBottleneck: Memory capacity

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 432.3 GB, exceeds 128.0 GB available

432.3 GB required128.0 GB available

338% VRAM needed

304.3 GB over capacity — needs offload or smaller quantization

Fit status

Too heavy

Decode

2.0 tok/s

TTFT

96800 ms

Safe context

Memory

432.3 GB / 128.0 GB

Offload

70%

Memory breakdown

Weights411.8 GB

KV Cache5.4 GB

Runtime2.4 GB

Headroom12.8 GB

See how fast it feels

With memory offload — actual speed may be lower

See how fast it feelsMistral Large 3 on AMD Instinct MI250 128GB
1st promptCold start — includes initialization
>Write a Python function to sort a list
Here's a Python function that sorts a list using quicksort:

def quicksort(arr):
    if len(arr) <= 1:
        return arr
    pivot = arr[len(arr) // 2]
    left   = [x for x in arr if x < pivot]
    middle = [x for x in arr if x == pivot]
    right  = [x for x in arr if x > pivot]
    return quicksort(left) + middle + quicksort(right)

# Example usage
numbers = [3, 6, 8, 10, 1, 2, 1]
print(quicksort(numbers))  # [1, 1, 2, 3, 6, 8, 10]

The algorithm picks a pivot, partitions the list into smaller, equal, and larger elements, then recursively sorts each partition and concatenates the results.
2nd promptWarm — model ready, no init overhead
>Now add type hints and a docstring
def quicksort(arr: list[int]) -> list[int]:
    """Sort a list using the quicksort algorithm.

    Args:
        arr: List of integers to sort.

    Returns:
        A new sorted list.
    """
    if len(arr) <= 1:
        return arr
    pivot = arr[len(arr) // 2]
    left   = [x for x in arr if x < pivot]
    middle = [x for x in arr if x == pivot]
    right  = [x for x in arr if x > pivot]
    return quicksort(left) + middle + quicksort(right)

Added type hints for the input and return type, plus a Google-style docstring.
Estimated: 2.0 tok/s decode · 96.8s TTFT (warm) · 5 tok/s prefill

What limits this setup

Usable VRAM is the main blocker for this model.

Not enough usable memory

The model needs 432.3 GB, but this setup only exposes 128.0 GB of usable VRAM.

Best improvement path

Add more VRAM headroom

The first useful upgrade is more dedicated VRAM so you can fit the model without shrinking context or dropping to a much lower quant.

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	F	Too heavy	2.0 tok/s	52800 ms	4K
Coding	F	Too heavy	2.0 tok/s	96800 ms	4K
Agentic Coding	F	Too heavy	2.0 tok/s	140800 ms	4K
Reasoning	F	Too heavy	2.0 tok/s	114400 ms	4K
RAG	F	Too heavy	2.0 tok/s	176000 ms	4K

Quantization options

How Mistral Large 3 (675B params) fits at each quantization level on AMD Instinct MI250 128GB (128.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	263.3 GB	Low	F0
Q3_K_S	3	330.8 GB	Low	F0
NVFP4	4

Frequently asked questions

Can AMD Instinct MI250 128GB run Mistral Large 3?

No, Mistral Large 3 requires more memory than AMD Instinct MI250 128GB provides.

How much VRAM does Mistral Large 3 need?

Mistral Large 3 (675B parameters) requires approximately 432.3 GB of memory with Q4_K_M quantization.

What is the best quantization for Mistral Large 3?

The recommended quantization for Mistral Large 3 is Q4_K_M, which balances quality and memory efficiency.

What speed will Mistral Large 3 run at on AMD Instinct MI250 128GB?

On AMD Instinct MI250 128GB, Mistral Large 3 achieves approximately 2.0 tokens per second decode speed with a time-to-first-token of 96800ms using Q4_K_M quantization.

Can AMD Instinct MI250 128GB run Mistral Large 3 for coding?

For coding workloads, Mistral Large 3 on AMD Instinct MI250 128GB receives a F grade with 2.0 tok/s and 4K context.

What context window can Mistral Large 3 use on AMD Instinct MI250 128GB?

On AMD Instinct MI250 128GB, Mistral Large 3 can safely use up to 4K tokens of context. The model's official context limit is 256K, but available memory constrains the safe maximum.

What should I upgrade first if Mistral Large 3 feels slow on AMD Instinct MI250 128GB?

See all results for AMD Instinct MI250 128GB See all hardware for Mistral Large 3

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