Can Llama 4 Maverick 17B 128E run on AMD Instinct MI210 64GB?

Q: What should I upgrade first if Llama 4 Maverick 17B 128E feels slow on AMD Instinct MI210 64GB?

Add more VRAM headroom. The first useful upgrade is more dedicated VRAM so you can fit the model without shrinking context or dropping to a much lower quant.

NO — Won't Fit

F0Won't run

Estimated from fit model

Llama 4 Maverick 17B 128E needs ~254.2 GB but AMD Instinct MI210 64GB only has 64.0 GB. Try a smaller quantization or lighter model.

Runtime: llama.cppCapacity: No fitBandwidth: HighStack: StandardBottleneck: Memory capacity

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 254.2 GB, exceeds 64.0 GB available

254.2 GB required64.0 GB available

397% VRAM needed

190.2 GB over capacity — needs offload or smaller quantization

Fit status

Too heavy

Decode

2.2 tok/s

TTFT

87439 ms

Safe context

Memory

254.2 GB / 64.0 GB

Offload

70%

Memory breakdown

Weights244.0 GB

KV Cache2.9 GB

Runtime0.9 GB

Headroom6.4 GB

See how fast it feels

With memory offload — actual speed may be lower

See how fast it feelsLlama 4 Maverick 17B 128E on AMD Instinct MI210 64GB
1st promptCold start — includes initialization
>Solve: If a train travels at 60 mph for 2.5 hours, how far does it go?
Let me work through this step by step.

Given information:
  - Speed = 60 mph (miles per hour)
  - Time  = 2.5 hours

Formula: Distance = Speed x Time

Calculation:
  Distance = 60 mph x 2.5 h
           = 150 miles

The train travels 150 miles.

Double-check: at 60 mph the train covers 60 miles each hour. In half an hour it covers 30 miles. So in 2.5 hours: 60 + 60 + 30 = 150 miles. Confirmed.
2nd promptWarm — model ready, no init overhead
>What if the train stops for 20 minutes halfway?
The stop doesn't change the total distance covered while moving, but it affects total trip time.

Breakdown:
  - First half: 1.25 hours at 60 mph = 75 miles
  - Stop: 20 minutes (no distance)
  - Second half: 1.25 hours at 60 mph = 75 miles

Total distance: 150 miles (same)
Total time: 2.5 h + 0.33 h = 2.83 hours
Average speed: 150 / 2.83 = 53 mph

The distance stays the same but average speed drops to 53 mph because of the stop.
Estimated: 2.2 tok/s decode · 87.4s TTFT (warm) · 6 tok/s prefill

What limits this setup

Usable VRAM is the main blocker for this model.

Not enough usable memory

The model needs 254.2 GB, but this setup only exposes 64.0 GB of usable VRAM.

Best improvement path

Add more VRAM headroom

The first useful upgrade is more dedicated VRAM so you can fit the model without shrinking context or dropping to a much lower quant.

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	F	Too heavy	2.2 tok/s	47694 ms	4K
Coding	F	Too heavy	2.2 tok/s	87439 ms	4K
Agentic Coding	F	Too heavy	2.2 tok/s	127184 ms	4K
Reasoning	F	Too heavy	2.2 tok/s	103337 ms	4K
RAG	F	Too heavy	2.2 tok/s	158980 ms	4K

Quantization options

How Llama 4 Maverick 17B 128E (400B params) fits at each quantization level on AMD Instinct MI210 64GB (64.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	156.0 GB	Low	F0
Q3_K_S	3	196.0 GB	Low	F0
NVFP4	4

Upgrade options

Hardware that runs Llama 4 Maverick 17B 128E well

AMD Instinct MI350X 288GBBudget pick

288 GB VRAM (+224)8000 GB/s (+6362)

Makes the model fit on the accelerator instead of staying completely out of reach.77.4 tok/s decode

Makes the model fit on the accelerator instead of staying completely out of reach.

Removes host-memory offload, which is usually the single biggest latency and throughput win.

~$8,000 MSRP

AMD Instinct MI325X 256GBBest value

256 GB VRAM (+192)6000 GB/s (+4362)

Makes the model fit on the accelerator instead of staying completely out of reach.37.9 tok/s decode

Makes the model fit on the accelerator instead of staying completely out of reach.

Raises estimated decode speed by about 1623%.

~$20,000 MSRP

Frequently asked questions

Can AMD Instinct MI210 64GB run Llama 4 Maverick 17B 128E?

No, Llama 4 Maverick 17B 128E requires more memory than AMD Instinct MI210 64GB provides.

How much VRAM does Llama 4 Maverick 17B 128E need?

Llama 4 Maverick 17B 128E (400B parameters) requires approximately 254.2 GB of memory with Q4_K_M quantization.

What is the best quantization for Llama 4 Maverick 17B 128E?

The recommended quantization for Llama 4 Maverick 17B 128E is Q4_K_M, which balances quality and memory efficiency.

What speed will Llama 4 Maverick 17B 128E run at on AMD Instinct MI210 64GB?

On AMD Instinct MI210 64GB, Llama 4 Maverick 17B 128E achieves approximately 2.2 tokens per second decode speed with a time-to-first-token of 87439ms using Q4_K_M quantization.

Can AMD Instinct MI210 64GB run Llama 4 Maverick 17B 128E for coding?

For coding workloads, Llama 4 Maverick 17B 128E on AMD Instinct MI210 64GB receives a F grade with 2.2 tok/s and 4K context.

What context window can Llama 4 Maverick 17B 128E use on AMD Instinct MI210 64GB?

On AMD Instinct MI210 64GB, Llama 4 Maverick 17B 128E can safely use up to 4K tokens of context. The model's official context limit is 1.0M, but available memory constrains the safe maximum.

See all results for AMD Instinct MI210 64GB See all hardware for Llama 4 Maverick 17B 128E

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