Can Qwen3.5 4B run on AMD Instinct MI250X 128GB?

YES — Runs Great

C43Usable

Estimated from fit model

Qwen3.5 4B needs ~16.6 GB VRAM. AMD Instinct MI250X 128GB has 128.0 GB. With Q4_K_M quantization, expect ~56 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 16.6 GB, 56.0 tok/s, Runs well

16.6 GB required128.0 GB available

13% VRAM used

Fit status

Runs well

Decode

56.0 tok/s

TTFT

3457 ms

Safe context

3.8M

Memory

16.6 GB / 128.0 GB

Memory breakdown

Weights2.4 GB

KV Cache0.5 GB

Runtime0.9 GB

Headroom12.8 GB

See how fast it feels

See how fast it feelsQwen3.5 4B on AMD Instinct MI250X 128GB
1st promptCold start — includes initialization
>What is local AI inference?
Local AI inference means running an AI language model directly on your own hardware — your laptop, desktop, or server — instead of sending requests to a remote cloud API.

When you run inference locally the model weights are loaded into your GPU or unified memory. Each token you generate requires reading those weights from memory, so memory bandwidth is the main bottleneck for decode speed.

Key benefits of running locally:
  - Full privacy: your prompts never leave your machine
  - No per-token cost or rate limits
  - Works offline once the model is downloaded
  - Latency depends only on your hardware
2nd promptWarm — model ready, no init overhead
>How much VRAM do I need?
It depends on the model size and quantization level. A rough rule of thumb:

  Model size     Q4 (4-bit)    Q8 (8-bit)    FP16
  7B params      ~4.3 GB       ~7.5 GB       ~14 GB
  13B params     ~7.9 GB       ~13.9 GB      ~26 GB
  70B params     ~42.7 GB      ~74.9 GB      ~140 GB

Most people use 4-bit quantization (Q4_K_M) which gives 90-95% of full quality at a fraction of the memory. A 24 GB GPU can comfortably run most 7B-13B models.
Estimated: 56.0 tok/s decode · 3.5s TTFT (warm) · 140 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	C	Runs well	56.0 tok/s	1886 ms	3.8M
Coding	C	Runs well	56.0 tok/s	3457 ms	3.8M
Agentic Coding	C	Runs well	56.0 tok/s	5029 ms	3.8M
Reasoning	C	Runs well	56.0 tok/s	4086 ms	3.8M
RAG	C	Runs well	56.0 tok/s	6286 ms	3.8M

Quantization options

How Qwen3.5 4B (4B params) fits at each quantization level on AMD Instinct MI250X 128GB (128.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	1.6 GB	Low	D38
Q3_K_S	3	2.0 GB	Low	D38
NVFP4	4

Get started

Copy-paste commands to run Qwen3.5 4B on your machine.

Run

lms load hf-unsloth--qwen3-5-4b-gguf && lms server start

Upgrade options

Hardware that runs Qwen3.5 4B well

Mac Studio M3 Ultra 256GBBudget pick

256 GB Unified (+128)

Adds memory headroom for longer context windows and future model growth.56 tok/s decode

Adds memory headroom for longer context windows and future model growth.

~$6,999 MSRP

Frequently asked questions

Can AMD Instinct MI250X 128GB run Qwen3.5 4B?

Yes, AMD Instinct MI250X 128GB can run Qwen3.5 4B with a C grade (Runs well). Expected decode speed: 56.0 tok/s.

How much VRAM does Qwen3.5 4B need?

Qwen3.5 4B (4B parameters) requires approximately 16.6 GB of memory with Q4_K_M quantization.

What is the best quantization for Qwen3.5 4B?

The recommended quantization for Qwen3.5 4B is Q4_K_M, which balances quality and memory efficiency.

What speed will Qwen3.5 4B run at on AMD Instinct MI250X 128GB?

On AMD Instinct MI250X 128GB, Qwen3.5 4B achieves approximately 56.0 tokens per second decode speed with a time-to-first-token of 3457ms using Q4_K_M quantization.

Can AMD Instinct MI250X 128GB run Qwen3.5 4B for coding?

For coding workloads, Qwen3.5 4B on AMD Instinct MI250X 128GB receives a C grade with 56.0 tok/s and 3.8M context.

What context window can Qwen3.5 4B use on AMD Instinct MI250X 128GB?

On AMD Instinct MI250X 128GB, Qwen3.5 4B can safely use up to 3.8M tokens of context. The model's official context limit is —, but available memory constrains the safe maximum.

See all results for AMD Instinct MI250X 128GB See all hardware for Qwen3.5 4B

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