Can Qwen3.5 27B run on AMD Instinct MI60 32GB?

YES — Runs Great

C54Usable

Estimated from fit model

Qwen3.5 27B needs ~23.7 GB VRAM. AMD Instinct MI60 32GB has 32.0 GB. With Q4_K_M quantization, expect ~31 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 23.7 GB, 30.5 tok/s, Runs well

23.7 GB required32.0 GB available

74% VRAM used

Fit status

Runs well

Decode

30.5 tok/s

TTFT

6355 ms

Safe context

58K

Memory

23.7 GB / 32.0 GB

Memory breakdown

Weights16.5 GB

KV Cache3.2 GB

Runtime0.9 GB

Headroom3.2 GB

See how fast it feels

See how fast it feelsQwen3.5 27B on AMD Instinct MI60 32GB
1st promptCold start — includes initialization
>What is local AI inference?
Local AI inference means running an AI language model directly on your own hardware — your laptop, desktop, or server — instead of sending requests to a remote cloud API.

When you run inference locally the model weights are loaded into your GPU or unified memory. Each token you generate requires reading those weights from memory, so memory bandwidth is the main bottleneck for decode speed.

Key benefits of running locally:
  - Full privacy: your prompts never leave your machine
  - No per-token cost or rate limits
  - Works offline once the model is downloaded
  - Latency depends only on your hardware
2nd promptWarm — model ready, no init overhead
>How much VRAM do I need?
It depends on the model size and quantization level. A rough rule of thumb:

  Model size     Q4 (4-bit)    Q8 (8-bit)    FP16
  7B params      ~4.3 GB       ~7.5 GB       ~14 GB
  13B params     ~7.9 GB       ~13.9 GB      ~26 GB
  70B params     ~42.7 GB      ~74.9 GB      ~140 GB

Most people use 4-bit quantization (Q4_K_M) which gives 90-95% of full quality at a fraction of the memory. A 24 GB GPU can comfortably run most 7B-13B models.
Estimated: 30.5 tok/s decode · 6.4s TTFT (warm) · 76 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	C	Runs well	30.5 tok/s	3466 ms	58K
Coding	C	Runs well	30.5 tok/s	6355 ms	58K
Agentic Coding	C	Tight fit	30.5 tok/s	9243 ms	58K
Reasoning	C	Runs well	30.5 tok/s	7510 ms	58K
RAG	C	Tight fit	30.5 tok/s	11554 ms	58K

Quantization options

How Qwen3.5 27B (27B params) fits at each quantization level on AMD Instinct MI60 32GB (32.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	10.5 GB	Low	C47
Q3_K_S	3	13.2 GB	Low	C48
NVFP4	4

Get started

Copy-paste commands to run Qwen3.5 27B on your machine.

Run

docker run --rm -it ghcr.io/ggerganov/llama.cpp:full \
  --hf-repo "unsloth/Qwen3.5-27B-GGUF" \
  --hf-file "Qwen3.5-27B-GGUF-Q4_K_M.gguf" \
  -c 4096 -ngl 99

Upgrade options

Hardware that runs Qwen3.5 27B well

MacBook Pro M4 Max 48GBBudget pick

48 GB Unified (+16)

This setup is broadly balanced for this model.33.4 tok/s decode

~$2,499 MSRP

NVIDIA A100 40GBBest value

40 GB VRAM (+8)1555 GB/s (+531)

Raises estimated decode speed by about 160%.79.3 tok/s decode

Raises estimated decode speed by about 160%.

Adds memory headroom for longer context windows and future model growth.

~$10,000 MSRP

Frequently asked questions

Can AMD Instinct MI60 32GB run Qwen3.5 27B?

Yes, AMD Instinct MI60 32GB can run Qwen3.5 27B with a C grade (Runs well). Expected decode speed: 30.5 tok/s.

How much VRAM does Qwen3.5 27B need?

Qwen3.5 27B (27B parameters) requires approximately 23.7 GB of memory with Q4_K_M quantization.

What is the best quantization for Qwen3.5 27B?

The recommended quantization for Qwen3.5 27B is Q4_K_M, which balances quality and memory efficiency.

What speed will Qwen3.5 27B run at on AMD Instinct MI60 32GB?

On AMD Instinct MI60 32GB, Qwen3.5 27B achieves approximately 30.5 tokens per second decode speed with a time-to-first-token of 6355ms using Q4_K_M quantization.

Can AMD Instinct MI60 32GB run Qwen3.5 27B for coding?

For coding workloads, Qwen3.5 27B on AMD Instinct MI60 32GB receives a C grade with 30.5 tok/s and 58K context.

What context window can Qwen3.5 27B use on AMD Instinct MI60 32GB?

On AMD Instinct MI60 32GB, Qwen3.5 27B can safely use up to 58K tokens of context. The model's official context limit is —, but available memory constrains the safe maximum.

See all results for AMD Instinct MI60 32GB See all hardware for Qwen3.5 27B

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