Can DeepSeek R1 Distill Qwen 14B run on AMD Instinct MI350X 288GB?

YES — Runs Great

C45Usable

Estimated from fit model

DeepSeek R1 Distill Qwen 14B needs ~39.9 GB VRAM. AMD Instinct MI350X 288GB has 288.0 GB. With Q4_K_M quantization, expect ~196 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 39.9 GB, 196.0 tok/s, Runs well

39.9 GB required288.0 GB available

14% VRAM used

Fit status

Runs well

Decode

196.0 tok/s

TTFT

988 ms

Safe context

2.4M

Memory

39.9 GB / 288.0 GB

Memory breakdown

Weights8.5 GB

KV Cache1.6 GB

Runtime0.9 GB

Headroom28.8 GB

See how fast it feels

See how fast it feelsDeepSeek R1 Distill Qwen 14B on AMD Instinct MI350X 288GB
1st promptCold start — includes initialization
>Solve: If a train travels at 60 mph for 2.5 hours, how far does it go?
Let me work through this step by step.

Given information:
  - Speed = 60 mph (miles per hour)
  - Time  = 2.5 hours

Formula: Distance = Speed x Time

Calculation:
  Distance = 60 mph x 2.5 h
           = 150 miles

The train travels 150 miles.

Double-check: at 60 mph the train covers 60 miles each hour. In half an hour it covers 30 miles. So in 2.5 hours: 60 + 60 + 30 = 150 miles. Confirmed.
2nd promptWarm — model ready, no init overhead
>What if the train stops for 20 minutes halfway?
The stop doesn't change the total distance covered while moving, but it affects total trip time.

Breakdown:
  - First half: 1.25 hours at 60 mph = 75 miles
  - Stop: 20 minutes (no distance)
  - Second half: 1.25 hours at 60 mph = 75 miles

Total distance: 150 miles (same)
Total time: 2.5 h + 0.33 h = 2.83 hours
Average speed: 150 / 2.83 = 53 mph

The distance stays the same but average speed drops to 53 mph because of the stop.
Estimated: 196.0 tok/s decode · 988ms TTFT (warm) · 490 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	C	Runs well	196.0 tok/s	539 ms	2.4M
Coding	C	Runs well	196.0 tok/s	988 ms	2.4M
Agentic Coding	C	Runs well	196.0 tok/s	1437 ms	2.4M
Reasoning	C	Runs well	196.0 tok/s	1167 ms	2.4M
RAG	C	Runs well	196.0 tok/s	1796 ms	2.4M

Quantization options

How DeepSeek R1 Distill Qwen 14B (14B params) fits at each quantization level on AMD Instinct MI350X 288GB (288.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	5.5 GB	Low	D36
Q3_K_S	3	6.9 GB	Low	D36
NVFP4	4

Get started

Copy-paste commands to run DeepSeek R1 Distill Qwen 14B on your machine.

Run

lms load hf-unsloth--deepseek-r1-distill-qwen-14b-gguf && lms server start

Frequently asked questions

Can AMD Instinct MI350X 288GB run DeepSeek R1 Distill Qwen 14B?

Yes, AMD Instinct MI350X 288GB can run DeepSeek R1 Distill Qwen 14B with a C grade (Runs well). Expected decode speed: 196.0 tok/s.

How much VRAM does DeepSeek R1 Distill Qwen 14B need?

DeepSeek R1 Distill Qwen 14B (14B parameters) requires approximately 39.9 GB of memory with Q4_K_M quantization.

What is the best quantization for DeepSeek R1 Distill Qwen 14B?

The recommended quantization for DeepSeek R1 Distill Qwen 14B is Q4_K_M, which balances quality and memory efficiency.

What speed will DeepSeek R1 Distill Qwen 14B run at on AMD Instinct MI350X 288GB?

On AMD Instinct MI350X 288GB, DeepSeek R1 Distill Qwen 14B achieves approximately 196.0 tokens per second decode speed with a time-to-first-token of 988ms using Q4_K_M quantization.

Can AMD Instinct MI350X 288GB run DeepSeek R1 Distill Qwen 14B for coding?

For coding workloads, DeepSeek R1 Distill Qwen 14B on AMD Instinct MI350X 288GB receives a C grade with 196.0 tok/s and 2.4M context.

What context window can DeepSeek R1 Distill Qwen 14B use on AMD Instinct MI350X 288GB?

On AMD Instinct MI350X 288GB, DeepSeek R1 Distill Qwen 14B can safely use up to 2.4M tokens of context. The model's official context limit is —, but available memory constrains the safe maximum.

See all results for AMD Instinct MI350X 288GB See all hardware for DeepSeek R1 Distill Qwen 14B

Embed this result▼

Paste this snippet into any page to show a live fit card.

<iframe src="https://willitrunai.com/embed/hf-unsloth--deepseek-r1-distill-qwen-14b-gguf-on-instinct-mi350x-288gb" width="400" height="180" frameborder="0" style="border:none;border-radius:12px;overflow:hidden;" title="Will It Run AI — fit result"></iframe>

Preview: